Covid-19 Research

Case Report

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Drinking Water Containing Platinum-Palladium (Functional Nutrient Water) Improved Interstitial Pneumonia and COPD: A Case Report

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Satoshi Kawakami*, Taro Shirakawa, Kou Sakabe, Tsutomu Sato, Takaharu Ide, Shoichi Wajima, Ryutaro Suma and Yoshitaka Fukuzawa

Volume3-Issue6
Dates: Received: 2022-06-10 | Accepted: 2022-06-13 | Published: 2022-06-15
Pages: 687-692

Abstract

In this case, when a patient with interstitial pneumonia was given platinum palladium, improvement in respiratory function was observed. Generally, various treatment methods are used for interstitial pneumonia, but conservative therapy has been the main focus and no curative solution has been reached. In this case, there was a tendency for improvement in patients who took platinum palladium, so we reported it. Since it is only drunk, it is not invasive and has great benefits for patients. It has also been reported that COPD, which is also a respiratory disease, showed an improvement tendency by drinking platinum palladium. Although the mechanism is still unknown, it is considered that it is largely due to the antioxidant action by platinum palladium and the activation of AMPK. In the future, we would like to examine further cases and improve the mechanism.

FullText HTML FullText PDF DOI: 10.37871/jbres1498


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Copyright

© 2022 Kawakami S, et al. Distributed under Creative Commons CC-BY 4.0

How to cite this article

Kawakami S, Shirakawa T, Sakabe K, Sato T, Ide T, Wajima S, Suma R, Fukuzawa Y. Drinking Water Containing Platinum-Palladium (Functional Nutrient Water) Improved Interstitial Pneumonia and COPD: A Case Report. J Biomed Res Environ Sci. 2022 June 10; 3(6): 687-692. doi: 10.37871/jbres1498, Article ID: JBRES1498, Available at: https://www.jelsciences.com/articles/jbres1498.pdf


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References


  1. Lamb YN. Nintedanib: A Review in Fibrotic Interstitial Lung Diseases. Drugs. 2021 Apr;81(5):575-586. doi: 10.1007/s40265-021-01487-0. Epub 2021 Mar 25. Erratum in: Drugs. 2021 Apr 13;: Erratum in: Drugs. 2021 Jun;81(9):1133. PMID: 33765296; PMCID: PMC8163683.
  2. Renzoni EA, Poletti V, Mackintosh JA. Disease pathology in fibrotic interstitial lung disease: is it all about usual interstitial pneumonia? Lancet. 2021 Oct 16;398(10309):1437-1449. doi: 10.1016/S0140-6736(21)01961-9. Epub 2021 Sep 6. PMID: 34499865.
  3. Graney BA, Fischer A. Interstitial Pneumonia with Autoimmune Features. Ann Am Thorac Soc. 2019 May;16(5):525-533. doi: 10.1513/AnnalsATS.201808-565CME. PMID: 30695649; PMCID: PMC6850782.
  4. Reynolds C, Feary J, Cullinan P. Occupational Contributions to Interstitial Lung Disease. Clin Chest Med. 2020 Dec;41(4):697-707. doi: 10.1016/j.ccm.2020.08.015. PMID: 33153688.
  5. Renzoni EA, Poletti V, Mackintosh JA. Disease pathology in fibrotic interstitial lung disease: is it all about usual interstitial pneumonia? Lancet. 2021 Oct 16;398(10309):1437-1449. doi: 10.1016/S0140-6736(21)01961-9. Epub 2021 Sep 6. PMID: 34499865.
  6. Belloli EA, Beckford R, Hadley R, Flaherty KR. Idiopathic non-specific interstitial pneumonia. Respirology. 2016 Feb;21(2):259-68. doi: 10.1111/resp.12674. Epub 2015 Nov 13. PMID: 26564810.
  7. American Thoracic Society; European Respiratory Society. American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med. 2002 Jan 15;165(2):277-304. doi: 10.1164/ajrccm.165.2.ats01. Erratum in: Am J Respir Crit Care Med2002 Aug 1;166(3):426. PMID: 11790668.
  8. Maher TM, Wuyts W. Management of Fibrosing Interstitial Lung Diseases. Adv Ther. 2019 Jul;36(7):1518-1531. doi: 10.1007/s12325-019-00992-9. Epub 2019 May 22. PMID: 31119691; PMCID: PMC6824393.
  9. Takahashi H, Fujishima T, Koba H, Murakami S, Kurokawa K, Shibuya Y, Shiratori M, Kuroki Y, Abe S. Serum surfactant proteins A and D as prognostic factors in idiopathic pulmonary fibrosis and their relationship to disease extent. Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):1109-14. doi: 10.1164/ajrccm.162.3.9910080. PMID: 10988138.
  10. Chiba H, Otsuka M, Takahashi H. Significance of molecular biomarkers in idiopathic pulmonary fibrosis: A mini review. Respir Investig. 2018 Sep;56(5):384-391. doi: 10.1016/j.resinv.2018.06.001. Epub 2018 Jul 17. PMID: 30030108.
  11. Brasch F. Interstitielle Lungenerkrankungen [Interstitial pulmonary diseases]. Pathologe. 2006;27(2):116-132.
  12. Wong AW, Ryerson CJ, Guler SA. Progression of fibrosing interstitial lung disease. Respir Res. 2020 Jan 29;21(1):32. doi: 10.1186/s12931-020-1296-3. PMID: 31996266; PMCID: PMC6988233.
  13. Turin GM. Natural history and clinical management of emphysema in patients with and without Alpha1-Antitrypsin inhibitor deficiency. Annals of the New York Academy of Sciences. 1991;624(1):18-29.
  14. Tashkin DP, Detels R, Simmons M, Liu H, Coulson AH, Sayre J, Rokaw S. The UCLA population studies of chronic obstructive respiratory disease: XI. Impact of air pollution and smoking on annual change in forced expiratory volume in one second. Am J Respir Crit Care Med. 1994 May;149(5):1209-17. doi: 10.1164/ajrccm.149.5.8173761. PMID: 8173761.
  15. Stoller JK, Panos RJ, Krachman S, Doherty DE, Make B; Long-term Oxygen Treatment Trial Research Group. Oxygen therapy for patients with COPD: current evidence and the long-term oxygen treatment trial. Chest. 2010 Jul;138(1):179-87. doi: 10.1378/chest.09-2555. PMID: 20605816; PMCID: PMC2897694.
  16. Organization WH. World health statistics 2010. World Health Organization, Geneva, 2010.
  17. Young RP, Hopkins RJ, Christmas T, Black PN, Metcalf P, Gamble GD. COPD prevalence is increased in lung cancer, independent of age, sex and smoking history. Eur Respir J. 2009 Aug;34(2):380-6. doi: 10.1183/09031936.00144208. Epub 2009 Feb 5. PMID: 19196816.
  18. Fischer BM, Voynow JA, Ghio AJ. COPD: balancing oxidants and antioxidants. Int J Chron Obstruct Pulmon Dis. 2015 Feb 2;10:261-76. doi: 10.2147/COPD.S42414. PMID: 25673984; PMCID: PMC4321570.
  19. Moreira-Pais A, Ferreira R, Gil da Costa R. Platinum-induced muscle wasting in cancer chemotherapy: Mechanisms and potential targets for therapeutic intervention. Life Sci. 2018 Sep 1;208:1-9. doi: 10.1016/j.lfs.2018.07.010. Epub 2018 Jul 6. PMID: 30146014.
  20. Katarzyna M, Anna S, Zielinska-Blizniewska H, Ireneusz M. An Evaluation of the Antioxidant and Anticancer Properties of Complex Compounds of Copper (II), Platinum (II), Palladium (II) and Ruthenium (III) for Use in Cancer Therapy. Mini Rev Med Chem. 2018;18(16):1373-1381. doi: 10.2174/1389557518666180423145825. PMID: 29692246.
  21. Lee SJ, Yu Y, Jung HJ, Naik SS, Yeon S, Choi MY. Efficient recovery of palladium nanoparticles from industrial wastewater and their catalytic activity toward reduction of 4-nitrophenol. Chemosphere. 2021 Jan;262:128358. doi: 10.1016/j.chemosphere.2020.128358. Epub 2020 Sep 15. PMID: 33182147.
  22. Ucar Y, Brantley WA, Bhattiprolu SN, Johnston WM, McGlumphy EA. Characterization of cast-to implant components from five manufacturers. J Prosthet Dent. 2009 Oct;102(4):216-23. doi: 10.1016/S0022-3913(09)60156-6. PMID: 19782823.
  23. Okamoto H, Horii K, Fujisawa A, Yamamoto Y. Oxidative deterioration of platinum nanoparticle and its prevention by palladium. Exp Dermatol. 2012 Jul;21 Suppl 1:5-7. doi: 10.1111/j.1600-0625.2012.01494.x. PMID: 22626463.
  24. Shibuya S, Ozawa Y, Watanabe K, Izuo N, Toda T, Yokote K, Shimizu T. Palladium and platinum nanoparticles attenuate aging-like skin atrophy via antioxidant activity in mice. PLoS One. 2014 Oct 15;9(10):e109288. doi: 10.1371/journal.pone.0109288. PMID: 25333617; PMCID: PMC4198089.
  25. Satoshi Kawakami, Hiroyuki Ichikawa, Tsutomu Sato, Hiroki Kataoka, Takaharu Ide, Hayato Terayama, Kou Sakabe. Antioxidant ability of platinum-palladium-Study using soft drinks containing platinum-palladium. Journal of the Japan Society for Oral Functional Water. 2021;22(1):3-9.
  26. Yang B, Chen Y, Shi J. Reactive Oxygen Species (ROS)-Based Nanomedicine. Chem Rev. 2019 Apr 24;119(8):4881-4985. doi: 10.1021/acs.chemrev.8b00626. Epub 2019 Apr 11. PMID: 30973011.
  27. Binks SP, Dobrota M. Kinetics and mechanism of uptake of platinum-based pharmaceuticals by the rat small intestine. Biochem Pharmacol. 1990 Sep 15;40(6):1329-36. doi: 10.1016/0006-2952(90)90400-f. PMID: 2206139.
  28. Sable V, Maindan K, Kapdi AR, Shejwalkar PS, Hara K. Active Palladium Colloids via Palladacycle Degradation as Efficient Catalysts for Oxidative Homocoupling and Cross-Coupling of Aryl Boronic Acids. ACS Omega. 2017 Jan 24;2(1):204-217. doi: 10.1021/acsomega.6b00326. PMID: 31457222; PMCID: PMC6641007.
  29. Zhang WZ, Venardos K, Chin-Dusting J, Kaye DM. Adverse effects of cigarette smoke on NO bioavailability: role of arginine metabolism and oxidative stress. Hypertension. 2006 Aug;48(2):278-85. doi: 10.1161/01.HYP.0000231509.27406.42. Epub 2006 Jun 26. PMID: 16801489.
  30. Mittler R. ROS Are Good. Trends Plant Sci. 2017 Jan;22(1):11-19. doi: 10.1016/j.tplants.2016.08.002. Epub 2016 Sep 23. PMID: 27666517.
  31. Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, Gargiulo G, Testa G, Cacciatore F, Bonaduce D, Abete P. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018 Apr 26;13:757-772. doi: 10.2147/CIA.S158513. PMID: 29731617; PMCID: PMC5927356.
  32. Carling D. AMPK signalling in health and disease. Curr Opin Cell Biol. 2017 Apr;45:31-37. doi: 10.1016/j.ceb.2017.01.005. Epub 2017 Feb 21. PMID: 28232179.
  33. Boyer PD, Chance B, Ernster L, Mitchell P, Racker E, Slater EC. Oxidative phosphorylation and photophosphorylation. Annu Rev Biochem. 1977;46:955-66. doi: 10.1146/annurev.bi.46.070177.004515. PMID: 18361775.
  34. Cool B, Zinker B, Chiou W, Kifle L, Cao N, Perham M, Dickinson R, Adler A, Gagne G, Iyengar R, Zhao G, Marsh K, Kym P, Jung P, Camp HS, Frevert E. Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab. 2006 Jun;3(6):403-16. doi: 10.1016/j.cmet.2006.05.005. PMID: 16753576.
  35. Giordanetto F, Karis D. Direct AMP-activated protein kinase activators: a review of evidence from the patent literature. Expert Opin Ther Pat. 2012 Dec;22(12):1467-77. doi: 10.1517/13543776.2012.743994. Epub 2012 Nov 8. PMID: 23136886.
  36. Xiao B, Sanders MJ, Carmena D, Bright NJ, Haire LF, Underwood E, Patel BR, Heath RB, Walker PA, Hallen S, Giordanetto F, Martin SR, Carling D, Gamblin SJ. Structural basis of AMPK regulation by small molecule activators. Nat Commun. 2013;4:3017. doi: 10.1038/ncomms4017. PMID: 24352254; PMCID: PMC3905731.
  37. Herzig S, Shaw RJ. AMPK: guardian of metabolism and mitochondrial homeostasis. Nat Rev Mol Cell Biol. 2018 Feb;19(2):121-135. doi: 10.1038/nrm.2017.95. Epub 2017 Oct 4. PMID: 28974774; PMCID: PMC5780224.
  38. Mihaylova MM, Shaw RJ. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol. 2011 Sep 2;13(9):1016-23. doi: 10.1038/ncb2329. PMID: 21892142; PMCID: PMC3249400.
  39. Russell FM, Hardie DG. AMP-Activated Protein Kinase: Do We Need Activators or Inhibitors to Treat or Prevent Cancer? Int J Mol Sci. 2020 Dec 27;22(1):186. doi: 10.3390/ijms22010186. PMID: 33375416; PMCID: PMC7795930.
  40. Wu S, Zou MH. AMPK, Mitochondrial Function, and Cardiovascular Disease. Int J Mol Sci. 2020 Jul 15;21(14):4987. doi: 10.3390/ijms21144987. PMID: 32679729; PMCID: PMC7404275.
  41. Zhang D, Wang W, Sun X, Xu D, Wang C, Zhang Q, Wang H, Luo W, Chen Y, Chen H, Liu Z. AMPK regulates autophagy by phosphorylating BECN1 at threonine 388. Autophagy. 2016 Sep;12(9):1447-59. doi: 10.1080/15548627.2016.1185576. Epub 2016 Jun 15. PMID: 27304906; PMCID: PMC5082788.
  42. Bergeron R, Ren JM, Cadman KS, Moore IK, Perret P, Pypaert M, Young LH, Semenkovich CF, Shulman GI. Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis. Am J Physiol Endocrinol Metab. 2001 Dec;281(6):E1340-6. doi: 10.1152/ajpendo.2001.281.6.E1340. PMID: 11701451.
  43. Hwang JH, Kim YH, Noh JR, Choi DH, Kim KS, Lee CH. Enhanced Production of Adenosine Triphosphate by Pharmacological Activation of Adenosine Monophosphate-Activated Protein Kinase Ameliorates Acetaminophen-Induced Liver Injury. Mol Cells. 2015 Oct;38(10):843-50. doi: 10.14348/molcells.2015.0072. Epub 2015 Oct 2. PMID: 26434492; PMCID: PMC4625065.
  44. Hardie DG, Schaffer BE, Brunet A. AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs. Trends Cell Biol. 2016 Mar;26(3):190-201. doi: 10.1016/j.tcb.2015.10.013. Epub 2015 Nov 23. PMID: 26616193; PMCID: PMC5881568.
  45. Cheng XY, Li YY, Huang C, Li J, Yao HW. AMP-activated protein kinase reduces inflammatory responses and cellular senescence in pulmonary emphysema. Oncotarget. 2017 Apr 4;8(14):22513-22523. doi: 10.18632/oncotarget.15116. PMID: 28186975; PMCID: PMC5410241.


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