Covid-19 Research

Case Study

Simultaneous Echocardiogram and N-Terminal-Probrain Natriuretic Peptide Measurement in Neonates

Journal of Biomedical Research & Environmental Sciences article abstract with citation details, DOI, publication dates, subject areas, full text links, and references.

View DOI Submit Manuscript

Article Details

Publication record, authors, dates, abstract, and full text access.

Open Access
Article Type Case Study
Subject Medicine Group
OCLC 9506588453
Lillie Turnbough, Amber McKenna and Shabih Manzar*
Issue: Volume3-Issue4
Pages: 413-418
Received: 2022-04-14
Accepted: 2022-04-25
Published: 2022-04-29

Abstract

Natriuretic atrial peptides are secreted by the heart in response to the distension of the cardiac chambers, and the N-terminal-probrain natriuretic peptide (NT-proBNP) is used frequently by clinician as an indirect measure of cardiac distension. The direct way of getting the same information is echocardiogram which provides a structural and functional assessment of the heart in real time. This paper discusses the value of obtaining both investigations simultaneously. We examined four cases in which the data on simultaneously done NT-proBNP and echocardiogram was available. We concluded that although NT-proBNP used in conjunction with echocardiogram and clinical evaluation can be effective in monitoring neonatal cardiac hemodynamic status, but using NT-proBNP and echocardiogram at the same time is not necessary. Following clinical suspicion and initial echocardiogram, NT-proBNP can be used to trend the infant's status and guide treatment. As our sample size was small, further research using a multicenter trial would be needed to confirm our conclusions, and that could lead to the development of institutional guidelines benefiting both the hospital and patient alike.

FullText HTML FullText PDF DOI: 10.37871/jbres1458 Crossmark

Certificate of Publication

Certificate of Publication

Copyright

© 2022 Turnbough L, et al. Distributed under Creative Commons CC-BY 4.0 Creative CommonsAttribution

How to cite this article

Turnbough L, McKenna A, Manzar S. Simultaneous Echocardiogram and N-Terminal-Probrain Natriuretic Peptide Measurement in Neonates. J Biomed Res Environ Sci. 2022 Apr 29; 3(4): 413-418. doi: 10.37871/jbres1458, Article ID: JBRES1458, Available at: https://www.jelsciences.com/articles/jbres1458.pdf

Subject area(s)

Neonatal CarePediatrics

References

  1. Hall C. Essential biochemistry and physiology of (NT-pro) BNP. Eur J Heart Fail. 2004 Mar 15;6(3):257-60. doi: 10.1016/j.ejheart.2003.12.015. PMID: 14987573.
  2. Clerico A, Giannoni A, Vittorini S, Passino C. Thirty years of the heart as an endocrine organ: physiological role and clinical utility of cardiac natriuretic hormones. Am J Physiol Heart Circ Physiol. 2011 Jul;301(1):H12-20. doi: 10.1152/ajpheart.00226.2011. Epub 2011 May 6. PMID: 21551272.
  3. El-Khuffash AF, Amoruso M, Culliton M, Molloy EJ. N-terminal pro-B-type natriuretic peptide as a marker of ductal haemodynamic significance in preterm infants: a prospective observational study. Arch Dis Child Fetal Neonatal Ed. 2007 Sep;92(5):F421-2. doi: 10.1136/adc.2007.119701. PMID: 17712194; PMCID: PMC2675377.
  4. Choi BM, Lee KH, Eun BL, Yoo KH, Hong YS, Son CS, Lee JW. Utility of rapid B-type natriuretic peptide assay for diagnosis of symptomatic patent ductus arteriosus in preterm infants. Pediatrics. 2005 Mar;115(3):e255-61. doi: 10.1542/peds.2004-1837. Epub 2005 Feb 1. PMID: 15687418.
  5. Attridge JT, Kaufman DA, Lim DS. B-type natriuretic peptide concentrations to guide treatment of patent ductus arteriosus. Arch Dis Child Fetal Neonatal Ed. 2009 May;94(3):F178-82. doi: 10.1136/adc.2008.147587. Epub 2008 Nov 3. PMID: 18981033.
  6. Nuntnarumit P, Chongkongkiat P, Khositseth A. N-terminal-pro-brain natriuretic peptide: a guide for early targeted indomethacin therapy for patent ductus arteriosus in preterm Infants. Acta Paediatr. 2011 Sep;100(9):1217-21. doi: 10.1111/j.1651-2227.2011.02304.x. Epub 2011 May 5. PMID: 21457304.
  7. Rodríguez-Blanco S, Oulego-Erroz I, Alonso-Quintela P, Terroba-Seara S, Jiménez-González A, Palau-Benavides M. N-terminal-probrain natriuretic peptide as a biomarker of moderate to severe bronchopulmonary dysplasia in preterm infants: A prospective observational study. Pediatr Pulmonol. 2018 Aug;53(8):1073-1081. doi: 10.1002/ppul.24053. Epub 2018 May 23. PMID: 29790673.
  8. Cao Z, Jia Y, Zhu B. BNP and NT-proBNP as Diagnostic Biomarkers for Cardiac Dysfunction in Both Clinical and Forensic Medicine. Int J Mol Sci. 2019 Apr 12;20(8):1820. doi: 10.3390/ijms20081820. PMID: 31013779; PMCID: PMC6515513.
  9. Cantinotti M, Law Y, Vittorini S, Crocetti M, Marco M, Murzi B, Clerico A. The potential and limitations of plasma BNP measurement in the diagnosis, prognosis, and management of children with heart failure due to congenital cardiac disease: an update. Heart Fail Rev. 2014 Nov;19(6):727-42. doi: 10.1007/s10741-014-9422-2. PMID: 24473828.
  10. Harabor A, Soraisham AS. Utility of Targeted Neonatal Echocardiography in the Management of Neonatal Illness. J Ultrasound Med. 2015 Jul;34(7):1259-63. doi: 10.7863/ultra.34.7.1259. PMID: 26112629.
  11. Tissot C, Singh Y. Neonatal functional echocardiography. Curr Opin Pediatr. 2020 Apr;32(2):235-244. doi: 10.1097/MOP.0000000000000887. PMID: 32068595.
  12. Ferrandis MJ, Ryden I, Lindahl TL, Larsson A. Ruling out cardiac failure: cost-benefit analysis of a sequential testing strategy with NT-proBNP before echocardiography. Ups J Med Sci. 2013 May;118(2):75-9. doi: 10.3109/03009734.2012.751471. Epub 2012 Dec 12. PMID: 23230860; PMCID: PMC3633333.
  13. Moe GW, Howlett J, Januzzi JL, Zowall H; Canadian Multicenter Improved Management of Patients With Congestive Heart Failure (IMPROVE-CHF) Study Investigators. N-terminal pro-B-type natriuretic peptide testing improves the management of patients with suspected acute heart failure: primary results of the Canadian prospective randomized multicenter IMPROVE-CHF study. Circulation. 2007 Jun 19;115(24):3103-10. doi: 10.1161/CIRCULATIONAHA.106.666255. Epub 2007 Jun 4. PMID: 17548729.
Publish with JBRES — Peer-reviewed, multidisciplinary Open Access with rapid review, DOI, and global visibility.
Double-Blind CrossRef DOI Discoverable
Submit Manuscript Membership