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Does CA-125 have a Role in Early Diagnosis of Ovarian Malignancy in Non-Menopausal Women?

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Open Access
Article Type Research Article
Subject Medicine Group
OCLC JBRES Record
Momen Zakaria El Nadeim, Bahgat Korany Yassin Ahmed, Hanan Hosni Mowad, Nesreen Abdelfattah Abdallah Shehata* and Sara Abdallah Mohamed Salem
Issue: Volume3-Issue4
Pages: 393-396
Received: 2022-03-23
Accepted: 2022-04-21
Published: 2022-04-25

Abstract

Objective: Aim of this study is to assess the role of Cancer Antigen (CA-125) in detection of ovarian malignancy in premenopausal women with ovarian mass.

Methods: This observational study was carried out in (blinded). It included 200 women who had preliminary diagnosis of adnexal mass whatever its nature. Adnexal masses were detected either clinically or by ultrasound.

Results: The study shows distribution of different pathologies of malignancy, stage of malignancy at diagnosis and benign spectrum in investigated population. The study also reveals CA-125 cutoff point 35.1 and sensitivity and specificity reached 93.1% and 92.2% respectively. Area under the Curve (AUC) was 0.998, Positive Prediction Value (PPV) was 91.7% and Negative Prediction Value (NPV) was 92.1.

Conclusion: According to our results CA-125 could be suitable as an ovarian cancer detection marker.

FullText HTML FullText PDF DOI: 10.37871/jbres1454 Crossmark

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Copyright

© 2022 El Nadeim MZ, et al. Distributed under Creative Commons CC-BY 4.0 Creative CommonsAttribution

How to cite this article

El Nadeim MZ, Yassin Ahmed BK, Mowad HH, Abdallah Shehata NA, Mohamed Salem SA. Does CA-125 have a Role in Early Diagnosis of Ovarian Malignancy in Non-Menopausal Women?. J Biomed Res Environ Sci. 2022 Apr 25; 3(4): 393-396. doi: 10.37871/jbres1454, Article ID: JBRES1454, Available at: https://www.jelsciences.com/articles/jbres1454.pdf

Subject area(s)

Womens Health and CareGynecologyReproductive MedicineCancer

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