Momen Zakaria El Nadeim, Bahgat Korany Yassin Ahmed, Hanan Hosni Mowad, Nesreen Abdelfattah Abdallah Shehata* and Sara Abdallah Mohamed Salem
Volume3-Issue4
Dates: Received: 2022-03-23 | Accepted: 2022-04-21 | Published: 2022-04-25
Pages: 393-396
Abstract
Objective: Aim of this study is to assess the role of Cancer Antigen (CA-125) in detection of ovarian malignancy in premenopausal women with ovarian mass.
Methods: This observational study was carried out in (blinded). It included 200 women who had preliminary diagnosis of adnexal mass whatever its nature. Adnexal masses were detected either clinically or by ultrasound.
Results: The study shows distribution of different pathologies of malignancy, stage of malignancy at diagnosis and benign spectrum in investigated population. The study also reveals CA-125 cutoff point 35.1 and sensitivity and specificity reached 93.1% and 92.2% respectively. Area under the Curve (AUC) was 0.998, Positive Prediction Value (PPV) was 91.7% and Negative Prediction Value (NPV) was 92.1.
Conclusion: According to our results CA-125 could be suitable as an ovarian cancer detection marker.
FullText HTML
FullText PDF
DOI: 10.37871/jbres1454
Certificate of Publication
Copyright
© 2022 El Nadeim MZ, et al. Distributed under Creative Commons CC-BY 4.0 
How to cite this article
El Nadeim MZ, Yassin Ahmed BK, Mowad HH, Abdallah Shehata NA, Mohamed Salem SA. Does CA-125 have a Role in Early Diagnosis of Ovarian Malignancy in Non-Menopausal Women?. J Biomed Res Environ Sci. 2022 Apr 25; 3(4): 393-396. doi: 10.37871/jbres1454, Article ID: JBRES1454, Available at: https://www.jelsciences.com/articles/jbres1454.pdf
Subject area(s)
References
- Smith LH, Oi RH. Detection of malignant ovarian neoplasms: a review of the literature. I. Detection of the patient at risk; clinical, radiological and cytological detection. Obstet Gynecol Surv. 1984 Jun;39(6):313-28. PMID: 6374536.
- Heintz AP, Odicino F, Maisonneuve P, Quinn MA, Benedet JL, Creasman WT, Ngan HY, Pecorelli S, Beller U. Carcinoma of the fallopian tube. FIGO 26th Annual Report on the Results of Treatment in Gynecological Cancer. Int J Gynaecol Obstet. 2006 Nov;95 Suppl 1:S145-60. doi: 10.1016/S0020-7292(06)60032-5. PMID: 17161156.
- Lee H, Kim JW, Lee DS, Min SH. Combined Poziotinib with Manidipine Treatment Suppresses Ovarian Cancer Stem-Cell Proliferation and Stemness. Int J Mol Sci. 2020 Oct 6;21(19):7379. doi: 10.3390/ijms21197379. PMID: 33036254; PMCID: PMC7583017.
- Enakpene CA, Omigbodun AO, Goecke TW, Odukogbe AT, Beckmann MW. Preoperative evaluation and triage of women with suspicious adnexal masses using risk of malignancy index. J Obstet Gynaecol Res. 2009 Feb;35(1):131-8. doi: 10.1111/j.1447-0756.2008.00869.x. PMID: 19215560.
- Karlsen MA, Sandhu N, Høgdall C, Christensen IJ, Nedergaard L, Lundvall L, Engelholm SA, Pedersen AT, Hartwell D, Lydolph M, Laursen IA, Høgdall EV. Evaluation of HE4, CA125, risk of ovarian malignancy algorithm (ROMA) and risk of malignancy index (RMI) as diagnostic tools of epithelial ovarian cancer in patients with a pelvic mass. Gynecol Oncol. 2012 Nov;127(2):379-83. doi: 10.1016/j.ygyno.2012.07.106. Epub 2012 Jul 24. PMID: 22835718.
- Urban N, McIntosh MW, Andersen M, Karlan BY. Ovarian cancer screening. Hematol Oncol Clin North Am. 2003 Aug;17(4):989-1005, ix. doi: 10.1016/s0889-8588(03)00063-7. PMID: 12959188.
- Nolen B, Velikokhatnaya L, Marrangoni A, De Geest K, Lomakin A, Bast RC Jr, Lokshin A. Serum biomarker panels for the discrimination of benign from malignant cases in patients with an adnexal mass. Gynecol Oncol. 2010 Jun;117(3):440-5. doi: 10.1016/j.ygyno.2010.02.005. Epub 2010 Mar 24. PMID: 20334903; PMCID: PMC2873171.
- Folk JJ, Botsford M, Musa AG. Monitoring cancer antigen 125 levels in induction chemotherapy for epithelial ovarian carcinoma and predicting outcome of second-look procedure. Gynecol Oncol. 1995 May;57(2):178-82. doi: 10.1006/gyno.1995.1121. PMID: 7729730.
- Bashizadeh-Fakhar H, Rezaie-Tavirani M, Zali H, Faraji R, Kazem Nejad E, Aghazadeh M. The diagnostic value of serum cea, ca-125, and roma index in low-grade serous ovarian cancer. International Journal of Cancer Management. 2018;11(5). doi: 10.5812/ijcm.63397
- Moore RG, Miller MC, Disilvestro P, Landrum LM, Gajewski W, Ball JJ, Skates SJ. Evaluation of the diagnostic accuracy of the risk of ovarian malignancy algorithm in women with a pelvic mass. Obstet Gynecol. 2011 Aug;118(2 Pt 1):280-288. doi: 10.1097/AOG.0b013e318224fce2. PMID: 21775843; PMCID: PMC3594110.
- Liest AL, Omran AS, Mikiver R, Rosenberg P, Uppugunduri S. RMI and ROMA are equally effective in discriminating between benign and malignant gynecological tumors: A prospective population-based study. Acta Obstet Gynecol Scand. 2019 Jan;98(1):24-33. doi: 10.1111/aogs.13462. Epub 2018 Oct 30. PMID: 30216407.
- Van Gorp T, Cadron I, Despierre E, Daemen A, Leunen K, Amant F, Timmerman D, De Moor B, Vergote I. HE4 and CA125 as a diagnostic test in ovarian cancer: prospective validation of the Risk of Ovarian Malignancy Algorithm. Br J Cancer. 2011 Mar 1;104(5):863-70. doi: 10.1038/sj.bjc.6606092. Epub 2011 Feb 8. PMID: 21304524; PMCID: PMC3048204.
- Partheen K, Kristjansdottir B, Sundfeldt K. Evaluation of ovarian cancer biomarkers HE4 and CA-125 in women presenting with a suspicious cystic ovarian mass. J Gynecol Oncol. 2011 Dec;22(4):244-52. doi: 10.3802/jgo.2011.22.4.244. Epub 2011 Dec 5. PMID: 22247801; PMCID: PMC3254843.
- Ferraro S, Braga F, Lanzoni M, Boracchi P, Biganzoli EM, Panteghini M. Serum human epididymis protein 4 vs carbohydrate antigen 125 for ovarian cancer diagnosis: a systematic review. J Clin Pathol. 2013 Apr;66(4):273-81. doi: 10.1136/jclinpath-2012-201031. Epub 2013 Feb 20. PMID: 23426716.
- Dikmen ZG, Colak A, Dogan P, Tuncer S, Akbiyik F. Diagnostic performances of CA125, HE4, and ROMA index in ovarian cancer. Eur J Gynaecol Oncol. 2015;36(4):457-62. PMID: 26390703.
- Moore RG, Jabre-Raughley M, Brown AK, Robison KM, Miller MC, Allard WJ, Kurman RJ, Bast RC, Skates SJ. Comparison of a novel multiple marker assay vs the Risk of Malignancy Index for the prediction of epithelial ovarian cancer in patients with a pelvic mass. Am J Obstet Gynecol. 2010 Sep;203(3):228.e1-6. doi: 10.1016/j.ajog.2010.03.043. Epub 2010 May 14. PMID: 20471625; PMCID: PMC3594101.
- Bonfrer JM, Korse CM, Verstraeten RA, van Kamp GJ, Hart GA, Kenemans P. Clinical evaluation of the Byk LIA-mat CA125 II assay: discussion of a reference value. Clin Chem. 1997 Mar;43(3):491-7. PMID: 9068593.
- Lycke M, Kristjansdottir B, Sundfeldt K. A multicenter clinical trial validating the performance of HE4, CA125, risk of ovarian malignancy algorithm and risk of malignancy index. Gynecol Oncol. 2018 Oct;151(1):159-165. doi: 10.1016/j.ygyno.2018.08.025. Epub 2018 Aug 24. PMID: 30149898.
- Chang X, Ye X, Dong L, Cheng H, Cheng Y, Zhu L, Liao Q, Zhao Y, Tian L, Fu T, Chen J, Cui H. Human epididymis protein 4 (HE4) as a serum tumor biomarker in patients with ovarian carcinoma. Int J Gynecol Cancer. 2011 Jul;21(5):852-8. doi: 10.1097/IGC.0b013e31821a3726. PMID: 21633297.
- Oranratanaphan S, Wanishpongpan S, Termrungruanglert W, Triratanachat S. Assessment of Diagnostic Values among CA-125, RMI, HE4, and ROMA for Cancer Prediction in Women with Nonfunctional Ovarian Cysts. Obstet Gynecol Int. 2018 Oct 8;2018:7821574. doi: 10.1155/2018/7821574. PMID: 30402106; PMCID: PMC6196978.
- Molina R, Escudero JM, Augé JM, Filella X, Foj L, Torné A, Lejarcegui J, Pahisa J. HE4 a novel tumour marker for ovarian cancer: comparison with CA 125 and ROMA algorithm in patients with gynaecological diseases. Tumour Biol. 2011 Dec;32(6):1087-95. doi: 10.1007/s13277-011-0204-3. Epub 2011 Aug 24. PMID: 21863264; PMCID: PMC3195682.
- Chan KK, Chen CA, Nam JH, Ochiai K, Wilailak S, Choon AT, Sabaratnam S, Hebbar S, Sickan J, Schodin BA, Sumpaico WW. The use of HE4 in the prediction of ovarian cancer in Asian women with a pelvic mass. Gynecol Oncol. 2013 Feb;128(2):239-44. doi: 10.1016/j.ygyno.2012.09.034. Epub 2012 Oct 10. PMID: 23063998.
- Roy LCB. Validity of the risk of malignancy index in malignant ovarian tumours. International Journal of Scientific Research. 2019;8(11).
- Menon U, Gentry-Maharaj A, Burnell M, Singh N, Ryan A, Karpinskyj C, Carlino G, Taylor J, Massingham SK, Raikou M, Kalsi JK, Woolas R, Manchanda R, Arora R, Casey L, Dawnay A, Dobbs S, Leeson S, Mould T, Seif MW, Sharma A, Williamson K, Liu Y, Fallowfield L, McGuire AJ, Campbell S, Skates SJ, Jacobs IJ, Parmar M. Ovarian cancer population screening and mortality after long-term follow-up in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial. Lancet. 2021 Jun 5;397(10290):2182-2193. doi: 10.1016/S0140-6736(21)00731-5. Epub 2021 May 12. PMID: 33991479; PMCID: PMC8192829.
