Covid-19 Research

Original Article

A Comparative Study of Cadmium Levels in Brain Tissue of Mice Observed Over Two Generations after Exposure During their Perinatal Period: Modulation by Quercetin

Journal of Biomedical Research & Environmental Sciences article abstract with citation details, DOI, publication dates, subject areas, full text links, and references.

View DOI Submit Manuscript

Article Details

Publication record, authors, dates, abstract, and full text access.

Open Access
Article Type Original Article
Subject Environmental Sciences
OCLC 9506575322
Sumita Halder*, Rajarshi Kar, Sucharita Chakraborty, Swapan K Bhattacharya and Basu D Banerjee
Issue: Volume3-Issue4
Pages: 327-331
Received: 2022-03-11
Accepted: 2022-04-13
Published: 2022-04-13

Abstract

The perinatal period is very critical as the embryo or the new born is more susceptible to Cd toxicity. This study was done to measure Cd levels in brain tissue of F1 and F2 generation mice whose mothers were exposed to Cd during lactation or during the entire period of gestation and lactation and also to investigate whether quercetin could modulate this effect. Dams were exposed to cadmium during lactation and during the entire perinatal period. F1 and F2 generations were reared till 100 days of age. After being sacrificed, their brains were extracted, and cadmium levels were estimated using Atomic absorption spectrophotometer. It was found that Cd levels in brain tissue were significantly higher in the F1 generation when animals were exposed in lactation. There was slight increase in Cd in brain tissue of animals exposed during gestation as well as lactation, but the change was not statistically significant. Quercetin reduced the Cd levels significantly in a dose dependent manner in lactation group. In the other two groups it reduced the Cd levels even lower than the controls. This study shows that Cd is passed on to the next generation more efficiently when exposed during lactation. Lesser transmission is seen when exposure is during gestation followed by lactation. Quercetin effectively reduces Cd levels in brain tissue irrespective of the type of exposure.

FullText HTML FullText PDF DOI: 10.37871/jbres1443 Crossmark

Certificate of Publication

Certificate of Publication

Copyright

© 2022 Halder S, et al. Distributed under Creative Commons CC-BY 4.0 Creative CommonsAttribution

How to cite this article

Halder S, Kar R, Chakraborty S, Bhattacharya SK, Banerjee BD. A Comparative Study of Cadmium Levels in Brain Tissue of Mice Observed Over Two Generations after Exposure During their Perinatal Period: Modulation by Quercetin. J Biomed Res Environ Sci. 2022 Apr 13; 3(4): 327-331. doi: 10.37871/jbres1443, Article ID: JBRES1443, Available at: https://www.jelsciences.com/articles/jbres1443.pdf

Subject area(s)

Environmental Contamination

References

  1. Mezynska M, Brzóska MM. Environmental exposure to cadmium-a risk for health of the general population in industrialized countries and preventive strategies. Environ Sci Pollut Res Int. 2018 Feb;25(4):3211-3232. doi: 10.1007/s11356-017-0827-z. Epub 2017 Dec 12. PMID: 29230653.
  2. Richter P, Faroon O, Pappas RS. Cadmium and Cadmium/Zinc Ratios and Tobacco-Related Morbidities. Int J Environ Res Public Health. 2017 Sep 29;14(10):1154. doi: 10.3390/ijerph14101154. PMID: 28961214; PMCID: PMC5664655.
  3. Espart A, Artime S, Tort-Nasarre G, Yara-Varón E. Cadmium exposure during pregnancy and lactation: materno-fetal and newborn repercussions of Cd(ii), and Cd-metallothionein complexes. Metallomics. 2018 Oct 17;10(10):1359-1367. doi: 10.1039/c8mt00174j. PMID: 30221266.
  4. García-Esquinas E, Pérez-Gómez B, Fernández-Navarro P, Fernández MA, de Paz C, Pérez-Meixeira AM, Gil E, Iriso A, Sanz JC, Astray J, Cisneros M, de Santos A, Asensio Á, García-Sagredo JM, García JF, Vioque J, López-Abente G, Pollán M, González MJ, Martínez M, Aragonés N. Lead, mercury and cadmium in umbilical cord blood and its association with parental epidemiological variables and birth factors. BMC Public Health. 2013 Sep 12;13:841. doi: 10.1186/1471-2458-13-841. PMID: 24028648; PMCID: PMC3848449.
  5. Rebelo FM, Caldas ED. Arsenic, lead, mercury and cadmium: Toxicity, levels in breast milk and the risks for breastfed infants. Environ Res. 2016 Nov;151:671-688. doi: 10.1016/j.envres.2016.08.027. Epub 2016 Sep 10. PMID: 27619212.
  6. Chao HH, Guo CH, Huang CB, Chen PC, Li HC, Hsiung DY, Chou YK. Arsenic, cadmium, lead, and aluminium concentrations in human milk at early stages of lactation. Pediatr Neonatol. 2014 Apr;55(2):127-34. doi: 10.1016/j.pedneo.2013.08.005. Epub 2013 Nov 11. PMID: 24231114.
  7. Kippler M, Lönnerdal B, Goessler W, Ekström EC, Arifeen SE, Vahter M. Cadmium interacts with the transport of essential micronutrients in the mammary gland - a study in rural Bangladeshi women. Toxicology. 2009 Mar 4;257(1-2):64-9. doi: 10.1016/j.tox.2008.12.009. Epub 2008 Dec 14. PMID: 19126424.
  8. Halder S, Kar R, Chakraborty S, Bhattacharya SK, Mediratta PK, Banerjee BD. Cadmium level in brain correlates with memory impairment in F1 and F2 generation mice: improvement with quercetin. Environ Sci Pollut Res Int. 2019 Apr;26(10):9632-9639. doi: 10.1007/s11356-019-04283-2. Epub 2019 Feb 7. PMID: 30734250.
  9. Yuan Y, Ma S, Qi Y, Wei X, Cai H, Dong L, Lu Y, Zhang Y, Guo Q. Quercetin inhibited cadmium-induced autophagy in the mouse kidney via inhibition of oxidative stress. J Toxicol Pathol. 2016 Oct;29(4):247-252. doi: 10.1293/tox.2016-0026. Epub 2016 Aug 18. PMID: 27821909; PMCID: PMC5097967.
  10. Sanhueza J, Valdes J, Campos R, Garrido A, Valenzuela A. Changes in the xanthine dehydrogenase/xanthine oxidase ratio in the rat kidney subjected to ischemia-reperfusion stress: preventive effect of some flavonoids. Res Commun Chem Pathol Pharmacol. 1992 Nov;78(2):211-8. PMID: 1475527.
  11. Primikyri A, Mazzone G, Lekka C, Tzakos AG, Russo N, Gerothanassis IP. Understanding zinc(II) chelation with quercetin and luteolin: a combined NMR and theoretical study. J Phys Chem B. 2015 Jan 8;119(1):83-95. doi: 10.1021/jp509752s. Epub 2014 Dec 17. PMID: 25486072.
  12. Halder S, Kar R, Galav V, Mehta AK, Bhattacharya SK, Mediratta PK, Banerjee BD. Cadmium exposure during lactation causes learning and memory-impairment in F1 generation mice: amelioration by quercetin. Drug Chem Toxicol. 2016;39(3):272-8. doi: 10.3109/01480545.2015.1092042. Epub 2015 Oct 7. PMID: 26446883.
  13. Chakraborty P, Ramteke D, Chakraborty S, Chennuri K, Bardhan P. Relationship between the lability of sediment-bound Cd and its bioaccumulation in edible oyster. Mar Pollut Bull. 2015 Nov 15;100(1):344-351. doi: 10.1016/j.marpolbul.2015.08.027. Epub 2015 Sep 8. PMID: 26359116.
  14. Chakraborty P, Ramteke D, Gadi SD, Bardhan P. Linkage between speciation of Cd in mangrove sediment and its bioaccumulation in total soft tissue of oyster from the west coast of India. Mar Pollut Bull. 2016 May 15;106(1-2):274-82. doi: 10.1016/j.marpolbul.2015.12.025. Epub 2016 Feb 10. PMID: 26874748.
  15. Wang B, Du Y. Cadmium and its neurotoxic effects. Oxid Med Cell Longev. 2013;2013:898034. doi: 10.1155/2013/898034. Epub 2013 Aug 12. PMID: 23997854; PMCID: PMC3753751.
  16. Gundacker C, Hengstschläger M. The role of the placenta in fetal exposure to heavy metals. Wien Med Wochenschr. 2012 May;162(9-10):201-6. doi: 10.1007/s10354-012-0074-3. PMID: 22717874.
  17. Goyer RA, Cherian MG. Role of metallothionein in human placenta and rats exposed to cadmium. IARC Sci Publ. 1992;(118):239-47. PMID: 1303947.
  18. Ravichandran R, Rajendran M, Devapiriam D. Antioxidant study of quercetin and their metal complex and determination of stability constant by spectrophotometry method. Food Chem. 2014 Mar 1;146:472-8. doi: 10.1016/j.foodchem.2013.09.080. Epub 2013 Sep 23. PMID: 24176370.
  19. Kim MY, Shon WJ, Park MN, Lee YS, Shin DM. Protective effect of dietary chitosan on cadmium accumulation in rats. Nutr Res Pract. 2016 Feb;10(1):19-25. doi: 10.4162/nrp.2016.10.1.19. Epub 2015 Dec 11. PMID: 26865912; PMCID: PMC4742306.
Publish with JBRES — Peer-reviewed, multidisciplinary Open Access with rapid review, DOI, and global visibility.
Double-Blind CrossRef DOI Discoverable
Submit Manuscript Membership