Covid-19 Research

Original Article

OCLC Number/Unique Identifier: 9427627243

Association of eNOS and STAT6 Gene Polymorphisms with the Susceptibility of Polycystic Ovary Syndrome in South Indian Women

Medicine Group    Start Submission

Manjula Bhanoori*, Veena KV, Swapna Siddamalla, Praveen Guruvaiah, Tumu Venkat Reddy, Suresh Govatati, Mamata Deenadayal and Sisinthy Shivaji

Volume3-Issue1
Dates: Received: 2021-12-28 | Accepted: 2022-01-07 | Published: 2022-01-08
Pages: 007-013

Abstract

Purpose: Polycystic Ovary Syndrome (PCOS) is a complex multifactorial endocrine metabolic disorder of reproductive-aged women characterized by hyperandrogenism, hirsutism, anovulation, hyperinsulinemia and polycystic ovaries. The main aim of this study was to investigate the association of eNOS and STAT6 gene Single Nucleotide Polymorphisms (SNPs) with the susceptibility of PCOS in South Indian Women.

Research question: What is the association status of eNOS and STAT6 SNPs with PCOS?

Methods: The present genetic association study involves clinically confirmed PCOS patients (n = 105) and non-PCOS controls (n = 110) of the Dravidian linguistic group. Genotyping of +894G/T (Glu298Asp) SNP of eNOS and 2964G/A SNP of STAT6 was performed by Polymerase Chain Reaction (PCR) and sequencing analysis.

Results: There were statistically significant differences in the genotype and allele frequencies of eNOS+894G/T (p = 0.1110) and STAT62964G/A (0.0019) between the cases and controls, according to codominant, dominant and recessive genotype models.

Conclusion: In conclusion, the eNOS and STAT6 gene polymorphisms may constitute an inheritable risk factor for PCOS in South Indian women.

FullText HTML FullText PDF DOI: 10.37871/jbres1393


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Copyright

© 2022 Bhanoori M, et al. Distributed under Creative Commons CC-BY 4.0

How to cite this article

Bhanoori M, Veena KV, Siddamalla S, Guruvaiah P, Reddy TV, Govatati S, Deenadayal M, Shivaji S. Association of eNOS and STAT6 Gene Polymorphisms with the Susceptibility of Polycystic Ovary Syndrome in South Indian Women. J Biomed Res Environ Sci. 2022 Jan 08; 3(1): 007-013. doi: 10.37871/jbres1393, Article ID: JBRES1393, Available at: https://www.jelsciences.com/articles/jbres1393.pdf


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