Covid-19 Research

Case Report

OCLC Number/Unique Identifier: 9152972274

Carcinoma Ex Pleomorphic Adenoma of the Uvula - Case Report

General Science    Start Submission

Joana Borges da Costa*, Ana Isabel Goncalves, Andre Carcao, Joana Santos, Delfim Duarte and Miguel Viana

Volume2-Issue7
Dates: Received: 2021-06-21 | Accepted: 2021-07-03 | Published: 2021-07-05
Pages: 543-547

Abstract

Introduction: Carcinoma Ex Pleomorphic Adenoma (CEPA) results from the malignant transformation of a benign tumor of the Salivary Glands (SG), the Pleomorphic Adenoma (PA). PA is considered the most common salivary tumor with a 5% risk of malignant transformation and its excision is recommended. CEPA is a rare tumor, corresponding to 3.6% of all salivary tumors and 11.6% of all GS carcinomas. About 18% of CEPAs affect minor SG, with the palate being the most common location. The present work serves to describe a case of a CEPA of the Uvula Minor SG (UMSG).

Case Report: We present a case report of a 57-year-old patient, with no relevant medical history, referred to the ENT consultation due to the appearance and progressive growth of a painless uvula lesion. The objective ENT examination showed a 15 mm ulcerative-vegetating lesion with apparent origin on the posterior face of the uvula. The lesion was biopsied and histopathological examination identified the presence of a neoplasm of the minor SG, probably NOS adenocarcinoma. The patient underwent Computed Tomography (CT) scan that showed an irregularity of the uvula, with no signs of invasion of the remaining soft palate, without other significant pharyngo-laryngeal changes. The patient underwent partial pharyngectomy and bilateral selective cervical ganglion dissection, and the histopathology of the surgical specimen confirmed that it was an invasive CEPA, the malignant component of the tumor corresponding to a NOS adenocarcinoma of the UMSG. The patient has been followed up in the ENT consultation, with no signs so far of loco-regional recurrence.

Discussion/Conclusion: In the presented case, the patient probably developed an undiagnosed PA that had become malignant over time. Given that it is a poor prognosis neoplasm, it’s essential that the ENT specialists are aware of this disease, in order to facilitate and anticipate the diagnosis and treatment as much as possible.

FullText HTML FullText PDF DOI: 10.37871/jbres1274


Certificate of Publication




Copyright

© 2021 da Costa JB, et al. Distributed under Creative Commons CC-BY 4.0

How to cite this article

da Costa JB, Gonçalves AI, Carção A, Santos J, Duarte D, Viana M. Carcinoma Ex Pleomorphic Adenoma of the Uvula - Case Report. J Biomed Res Environ Sci. 2021 July 05; 2(7): 543-547. doi: 10.37871/jbres1274, Article ID: jbres1274, Available at: https://www.jelsciences.com/articles/jbres1274.pdf


Subject area(s)

References


  1. Barnes L, Eveson JW, Reichart P, Sidransky D. Pathology and Genetics of Head and Neck Tumours. In: WHO Classification of Tumours (Third edition), WHO Press, Geneva, Switzerland. 2005;9.
  2. Olsen KD, Lewis JE. Carcinoma ex pleomorphic adenoma: a clinicopathologic review. Head Neck. 2001 Sep;23(9):705-12. doi: 10.1002/hed.1100. PMID: 11505478.
  3. Gnepp DR. Malignant mixed tumors of the salivary glands: a review. Pathol Annu. 1993;28 Pt 1:279-328. PMID: 8380049.
  4. Nouraei SA, Hope KL, Kelly CG, McLean NR, Soames JV. Carcinoma ex benign pleomorphic adenoma of the parotid gland. Plast Reconstr Surg. 2005 Oct;116(5):1206-13. doi: 10.1097/01.prs.0000181654.68120.0f. PMID: 16217459.
  5. Weidner N, Cote R, Suster S, Weiss L. Modern Surgical Pathology, Volume 1 (2nd Edition), Saunders Elsevier, Philadelphia, United States of America. 2009.
  6. Jorge L, Gouveia M, Rodrigues J, Luís A. Carcinoma ex-adenoma pleomórfico - a propósito de um caso clínico. Rev Port Estomatol Med Dentária e Cir Maxilofac. 2013 Oct 1;54:e44.
  7. Cardesa A, Slootweg PJ, Gale A, Franchi A. Pathology of the Head and Neck (2nd Edition), Springer-Verlag Berlin Heidelberg, Heidelberg, Germany. 2016.
  8. Matsubayashi S, Yoshihara T. Carcinoma ex pleomorphic adenoma of the salivary gland: an immunohistochemical study. Eur Arch Otorhinolaryngol. 2007 Jul;264(7):789-95. doi: 10.1007/s00405-007-0256-6. Epub 2007 Feb 20. PMID: 17310348.
  9. Antony J, Gopalan V, Smith RA, Lam AK. Carcinoma ex pleomorphic adenoma: a comprehensive review of clinical, pathological and molecular data. Head Neck Pathol. 2012 Mar;6(1):1-9. doi: 10.1007/s12105-011-0281-z. Epub 2011 Jul 9. PMID: 21744105; PMCID: PMC3311945.
  10. Zbären P, Zbären S, Caversaccio MD, Stauffer E. Carcinoma ex pleomorphic adenoma: diagnostic difficulty and outcome. Otolaryngol Head Neck Surg. 2008 May;138(5):601-5. doi: 10.1016/j.otohns.2008.01.013. PMID: 18439465.
  11. Dewan K, Owens J, Silvester K. Maintaining a high level of suspicion for recurrent malignant disease: report of a case with periapical involvement. Int Endod J. 2007 Nov;40(11):900-7. doi: 10.1111/j.1365-2591.2007.01281.x. Epub 2007 Aug 30. PMID: 17764459.
  12. Keerthi R, Raut RP, Vaibhav N, Ghosh A. Carcinoma ex pleomorphic adenoma: Diagnostic dilemma and treatment protocol. Indian J Dent. 2014 Jul;5(3):157-60. doi: 10.4103/0975-962X.140840. PMID: 25565746; PMCID: PMC4213878.
  13. LiVolsi VA, Perzin KH. Malignant mixed tumors arising in salivary glands. I. Carcinomas arising in benign mixed tumors: a clinicopathologic study. Cancer. 1977 May;39(5):2209-30. doi: 10.1002/1097-0142(197705)39:5<2209::aid-cncr2820390540>3.0.co;2-8. PMID: 192443.
  14. Sedassari BT, da Silva Lascane NA, Tobouti PL, Pigatti FM, Franco MIF, de Sousa SCOM. Carcinoma ex pleomorphic adenoma of the palate composed of invasive micropapillary salivary duct carcinoma and adenoid cystic carcinoma components: an unusual case with immunohistochemical approach. Medicine (Baltimore). 2014 Dec;93(27):e146. doi: 10.1097/MD.0000000000000146. PMID: 25501054; PMCID: PMC4602770.
  15. Gerughty RM, Scofield HH, Brown FM, Hennigar GR. Malignant mixed tumors of salivary gland origin. Cancer. 1969 Sep;24(3):471-86. doi: 10.1002/1097-0142(196909)24:3<471::aid-cncr2820240309>3.0.co;2-0. PMID: 4310021.
  16. BEAHRS OH, WOOLNER LB, KIRKLIN JW, DEVINE KD. Carcinomatous transformation of mixed tumors of the parotid gland. AMA Arch Surg. 1957 Oct;75(4):605-13; discussion 613-4. doi: 10.1001/archsurg.1957.01280160115015. PMID: 13457639.
  17. Myers EN, Ferris RL. Salivary gland disorders. Ed. Springer (1st Edition). Springer-Verlag Berlin Heidelberg, Heidelberg, Germany. 2007;3:65-67.
  18. Altemani A, Martins MT, Freitas L, Soares F, Araújo NS, Araújo VC. Carcinoma ex pleomorphic adenoma (CXPA): immunoprofile of the cells involved in carcinomatous progression. Histopathology. 2005 Jun;46(6):635-41. doi: 10.1111/j.1365-2559.2005.02157.x. PMID: 15910594.
  19. Lüers JC, Wittekindt C, Streppel M, Guntinas-Lichius O. Carcinoma ex pleomorphic adenoma of the parotid gland. Study and implications for diagnostics and therapy. Acta Oncol. 2009;48(1):132-6. doi: 10.1080/02841860802183604. PMID: 18607845.
  20. Mitchell DA, Eveson JW, Ord RA. Polymorphous low-grade adenocarcinoma of minor salivary glands--a report of three cases. Br J Oral Maxillofac Surg. 1989 Dec;27(6):494-500. doi: 10.1016/s0266-4356(89)80008-7. PMID: 2688740.


Comments


Swift, Reliable, and studious. We aim to cherish the world by publishing precise knowledge.

  • UNSW Sidney Library
  • The University of Hong Kong Libraries
  • UC Santa Barbara Library
  • University of Toronto Libraries
  • University of Oxford Library
  • Australian National University
  • ScienceOpen
  • UIC Library
  • KAUST University Library
  • Cardiff University Library
  • Ball State University Library
  • Duke University Library
  • Rutgers University Library
  • Air University Library
  • UNT University of North Texas
  • Washington Research Library Consortium
  • Penn State University Library
  • Georgetown Library
  • Princeton University Library
  • Science Gate
  • Internet Archive
  • WashingTon State University Library
  • Dimensions
  • Zenodo
  • OpenAire
  • Index Copernicus International
  • icmje
  •  International Scientific Indexing (ISI)
  • Sherpa Romeo
  • ResearchGate
  • Universidad De Lima
  • WorldCat
  • JCU Discovery
  • McGill
  • National University of Singepore Libraries
  • SearchIT
  • Scilit
  • SemantiScholar
  • Base Search
  • VU
  • KB
  • Publons
  • oaji
  • Harvard University
  • sjsu-library
  • UWLSearch
  • Florida Institute of Technology
  • CrossRef
  • LUBsearch
  • Universitat de Paris
  • Technical University of Denmark
  • ResearchBIB
  • Google Scholar
  • Microsoft Academic Search

 

 

COVID-19 alert