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Case Report

OCLC Number/Unique Identifier: 9152972274

Carcinoma Ex Pleomorphic Adenoma of the Uvula - Case Report

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Joana Borges da Costa*, Ana Isabel Goncalves, Andre Carcao, Joana Santos, Delfim Duarte and Miguel Viana

Dates: Received: 2021-06-21 | Accepted: 2021-07-03 | Published: 2021-07-05
Pages: 543-547


Introduction: Carcinoma Ex Pleomorphic Adenoma (CEPA) results from the malignant transformation of a benign tumor of the Salivary Glands (SG), the Pleomorphic Adenoma (PA). PA is considered the most common salivary tumor with a 5% risk of malignant transformation and its excision is recommended. CEPA is a rare tumor, corresponding to 3.6% of all salivary tumors and 11.6% of all GS carcinomas. About 18% of CEPAs affect minor SG, with the palate being the most common location. The present work serves to describe a case of a CEPA of the Uvula Minor SG (UMSG).

Case Report: We present a case report of a 57-year-old patient, with no relevant medical history, referred to the ENT consultation due to the appearance and progressive growth of a painless uvula lesion. The objective ENT examination showed a 15 mm ulcerative-vegetating lesion with apparent origin on the posterior face of the uvula. The lesion was biopsied and histopathological examination identified the presence of a neoplasm of the minor SG, probably NOS adenocarcinoma. The patient underwent Computed Tomography (CT) scan that showed an irregularity of the uvula, with no signs of invasion of the remaining soft palate, without other significant pharyngo-laryngeal changes. The patient underwent partial pharyngectomy and bilateral selective cervical ganglion dissection, and the histopathology of the surgical specimen confirmed that it was an invasive CEPA, the malignant component of the tumor corresponding to a NOS adenocarcinoma of the UMSG. The patient has been followed up in the ENT consultation, with no signs so far of loco-regional recurrence.

Discussion/Conclusion: In the presented case, the patient probably developed an undiagnosed PA that had become malignant over time. Given that it is a poor prognosis neoplasm, it’s essential that the ENT specialists are aware of this disease, in order to facilitate and anticipate the diagnosis and treatment as much as possible.

FullText HTML FullText PDF DOI: 10.37871/jbres1274

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© 2021 da Costa JB, et al. Distributed under Creative Commons CC-BY 4.0

How to cite this article

da Costa JB, Gonçalves AI, Carção A, Santos J, Duarte D, Viana M. Carcinoma Ex Pleomorphic Adenoma of the Uvula - Case Report. J Biomed Res Environ Sci. 2021 July 05; 2(7): 543-547. doi: 10.37871/jbres1274, Article ID: jbres1274, Available at:

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