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Frequency Analysis Results Distribution of C589t Rs2243250 Polymorphism in Il4 Gene Among Patients with Chronic Rhinosinusitis

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Open Access
Article Type Research Article
Subject Medicine Group
OCLC 9124709728
Djuraev JA*, Khasanov US, Vokhidov UN and Botirov AJ
Issue: Volume2-Issue6
Pages: 486-492
Received: 2021-06-02
Accepted: 2021-06-13
Published: 2021-06-14

Abstract

The fairly widespread prevalence of CRSwNP along with the lack of remedies for curing the disease, a variety of hypotheses of etiology dictate the need for further study of all links in the pathogenesis and clinical features of the course of the disease. In the coming century of “biological medicine”, the availability of high technologies of medical genetics makes it possible to reveal the individual characteristics of the most important regulatory systems of the body, which opens up new prospects for studying the etiology and pathogenesis of CRSwNP. In the tissues of polyps and intranasal secretions, an increase in the concentration of various inflammatory mediators, in particular interleukins, is observed due to an increase in their de novo synthesis by effector cells. Particular importance is attached to an increase in the concentration of cytokines involved in the development, recruitment and activation of eosinophils (IL-4, IL-12, IL-13, GM-CSF), the main pro-inflammatory (IL-1, IL-2, TNF-a, IL- 10), regulatory cytokines (IL-10, TLR2B), contributing to the chronicity of the inflammatory process in the nasal cavity.

FullText HTML FullText PDF DOI: 10.37871/jbres1264 Crossmark

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© 2021 Djuraev JA, et al. Distributed under Creative Commons CC-BY 4.0 Creative CommonsAttribution

How to cite this article

Djuraev JA, Khasanov US, Vokhidov UN, Botirov AJ. Frequency Analysis Results Distribution of C589t Rs2243250 Polymorphism in Il4 Gene Among Patients with Chronic Rhinosinusitis. J Biomed Res Environ Sci. 2021 June 14; 2(6): 486-492. doi: 10.37871/jbres1264, Article ID: jbres1264

Subject area(s)

OtolaryngologyPublic Health

References

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