Kedar N Prasad*
Volume2-Issue5
Dates: Received: 2021-04-29 | Accepted: 2021-05-08 | Published: 2021-05-10
Pages: 311-314
Abstract
Costus species is a significant restorative and decorative plant used to fix various illnesses. In India 6,000 plants are used for traditional and herbal medicine. The plant Costus spicatus commonly known as ‘Spiral ginger’ as ‘insulin plant’, a wonder drug down blood sugar level and hypoglycemic properties. The plant has been found to have numerous pharmacological exercises, for example, antibacterial, antifungal, anticholineesterase, cancer prevention agent, antihyperglycemic, calming, pain relieving, antipyretic, antidiuretic, antistress and estrogenic action. The rhizomes of Costus species are harsh, astringent, bitter, cooling, love potion, laxative, anthelminthic, depurative, febrifuge, expectorant, tonic, improve assimilation, and is an energizer herb that clears poisons. It additionally has against richness, anabolic properties. This audit plainly demonstrates the need to perform logical investigations with therapeutic vegetation featuring potential for Costus species because of its antidiabetic, pharmacological and cell reinforcement properties. The rhizome is credited with purgative and tonic properties. India is a botanical garden of the world for natural resources.
FullText HTML
FullText PDF
DOI: 10.37871/jbres1232
Certificate of Publication
Copyright
© 2021 Prasad KN. Distributed under Creative Commons CC-BY 4.0 
How to cite this article
Prasad KN. A Micronutrient Mixture may Reduce the incidence and Improve the Effectiveness of Drug Therapy of Alzheimer’s Disease. J Biomed Res Environ Sci. 2021 May 10; 2(5): 311-314. doi: 10.37871/jbres1232, Article ID: jbres1232
Subject area(s)
References
- Alzheimer’s Association As. Facts and Figures Report 1. 2020.
- GBD 2016 Neurology Collaborators. Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019 May;18(5):459-480. doi: 10.1016/S1474-4422(18)30499-X. Epub 2019 Mar 14. PMID: 30879893; PMCID: PMC6459001.
- Prasad KN, Bondy SC. Inhibition of early upstream events in prodromal Alzheimer’s disease by use of targeted antioxidants. Curr Aging Sci. 2014;7(2):77-90. doi: 10.2174/1874609807666140804115633. PMID: 25101711.
- Prasad KN. Simultaneous activation of Nrf2 and elevation of antioxidant compounds for reducing oxidative stress and chronic inflammation in human Alzheimer’s disease. Mech Ageing Dev. 2016 Jan;153:41-7. doi: 10.1016/j.mad.2016.01.002. Epub 2016 Jan 23. PMID: 26811881.
- Ringman JM, Fithian AT, Gylys K, Cummings JL, Coppola G, Elashoff D, Pratico D, Moskovitz J, Bitan G. Plasma methionine sulfoxide in persons with familial Alzheimer’s disease mutations. Dement Geriatr Cogn Disord. 2012;33(4):219-25. doi: 10.1159/000338546. Epub 2012 May 14. PMID: 22584618; PMCID: PMC3568669.
- Selkoe DJ. Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer’s disease. Annu Rev Cell Biol. 1994;10:373-403. doi: 10.1146/annurev.cb.10.110194.002105. PMID: 7888181.
- Yankner BA, Mesulam MM. Seminars in medicine of the Beth Israel Hospital, Boston. beta-Amyloid and the pathogenesis of Alzheimer’s disease. N Engl J Med. 1991 Dec 26;325(26):1849-57. doi: 10.1056/NEJM199112263252605. PMID: 1961223.
- Gibson GE, Haroutunian V, Zhang H, Park LC, Shi Q, Lesser M, Mohs RC, Sheu RK, Blass JP. Mitochondrial damage in Alzheimer’s disease varies with apolipoprotein E genotype. Ann Neurol. 2000 Sep;48(3):297-303. PMID: 10976635.
- Shoffner JM, Brown MD, Torroni A, Lott MT, Cabell MF, Mirra SS, Beal MF, Yang CC, Gearing M, Salvo R, et al. Mitochondrial DNA variants observed in Alzheimer disease and Parkinson disease patients. Genomics. 1993 Jul;17(1):171-84. doi: 10.1006/geno.1993.1299. PMID: 8104867.
- Wallace DC. Mitochondrial genetics: a paradigm for aging and degenerative diseases? Science. 1992 May 1;256(5057):628-32. doi: 10.1126/science.1533953. PMID: 1533953.
- Checler F, da Costa CA, Ancolio K, Chevallier N, Lopez-Perez E, Marambaud P. Role of the proteasome in Alzheimer’s disease. Biochim Biophys Acta. 2000 Jul 26;1502(1):133-8. doi: 10.1016/s0925-4439(00)00039-9. PMID: 10899438.
- Braak H, Zetterberg H, Del Tredici K, Blennow K. Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid. Acta Neuropathol. 2013 Nov;126(5):631-41. doi: 10.1007/s00401-013-1139-0. Epub 2013 Jun 12. PMID: 23756600.
- Tai HC, Serrano-Pozo A, Hashimoto T, Frosch MP, Spires-Jones TL, Hyman BT. The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system. Am J Pathol. 2012 Oct;181(4):1426-35. doi: 10.1016/j.ajpath.2012.06.033. Epub 2012 Aug 4. Erratum in: Am J Pathol. 2012 Nov;181(5):1889-90. PMID: 22867711; PMCID: PMC3463637.
- Aging NIo. How is Alzheimer’s Disease Treated?. 2020.
- Gaziano JM, Sesso HD, Christen WG, Bubes V, Smith JP, MacFadyen J, Schvartz M, Manson JE, Glynn RJ, Buring JE. Multivitamins in the prevention of cancer in men: the Physicians’ Health Study II randomized controlled trial. JAMA. 2012 Nov 14;308(18):1871-80. doi: 10.1001/jama.2012.14641. Erratum in: JAMA. 2014 Aug 6;312(5):560. PMID: 23162860; PMCID: PMC3517179.
- Baum MK, Campa A, Lai S, Sales Martinez S, Tsalaile L, Burns P, Farahani M, Li Y, van Widenfelt E, Page JB, Bussmann H, Fawzi WW, Moyo S, Makhema J, Thior I, Essex M, Marlink R. Effect of micronutrient supplementation on disease progression in asymptomatic, antiretroviral-naive, HIV-infected adults in Botswana: a randomized clinical trial. JAMA. 2013 Nov 27;310(20):2154-63. doi: 10.1001/jama.2013.280923. PMID: 24281460; PMCID: PMC4347896.
