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Epithelial Cells Orchestrate the Functions of Dendritic Cells in Intestinal Homeostasis

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Open Access
Article Type Original Article
Subject Medicine Group
OCLC 8792619101
Tianming Li, Mei Liu, Siyu Sun, Xuying Liu and Dongyan Liu*
Issue: Volume1-Issue7
Pages: 343-352
Received: 2020-11-13
Accepted: 2020-11-23
Published: 2020-11-24

Abstract

The gastrointestinal tract represents the largest mucosal membrane surface and is the one of the most complex human organs. The intestinal barrier dysfunction contributes to systemic immune activation. The mucosal immune system has extremely arduous tasks to resist invaders and promote tolerance of food antigens and the microbiota. The intestinal mucosal immune system fulfills these tasks through complex interactions between immune cells and the local microenvironment in intestine. Intestinal Epithelial Cells (IECs) play important roles in these complex interactions. IECs not only constitute the first barrier of the intestine but also are crucial for integrating external and internal signals and for coordinating the ensuing immune response. Dendritic Cells (DCs) play key roles in shaping the intestinal immune response by their ability to coordinate protective immunity and immune tolerance in the host. DCs are pivotal actors in the connection between innate and adaptive immune responses. The IECs coordinate with the DCs in immune recognition, tolerance and host defense mechanisms. In this review, we will summarize how IECs orchestrate intestinal DCs in intestinal homeostasis and diseases.

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Copyright

© 2020 Li T, et al. Distributed under Creative Commons CC-BY 4.0 Creative CommonsAttribution

How to cite this article

Li T, Liu M, Sun S, Liu X, Liu D. Epithelial Cells Orchestrate the Functions If Dendritic Cells in Intestinal Homeostasis. J Biomed Res Environ Sci. 2020 Nov 24; 1(7): 343-352. doi: 10.37871/jbres1165, Article ID: jbres1165

Subject area(s)

ImmunotherapyImmunologyPediatrics

University/Institute

China Medical University

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