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Platelet Aggregation Modulation by a Cholesterol Derivative identified in Skin Secretions from Arabian Gulf Catfish (Arius bilineatus, Val.)

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Open Access
Article Type Short Communication
Subject Medicine Group
OCLC JBRES Record
Jassim M Al-Hassan, Mohammad Afzal, Sosamma Oommen, Yuan Fang Liu, Meraj Khan and Cecil Pace-Asciak*
Issue: Volume5-Issue11
Pages: 1525-1530
Received: 2024-11-14
Accepted: 2024-11-26
Published: 2024-11-30

Abstract

We present in this study that one Oxysterol (OS) within the lipid fraction of the isolated epidermal gel released from freshly caught catfish from the Arabian Gulf (Arius bilineatus, Val.) potently and selectively inhibits the collagen-evoked aggregation of human platelets in vitro. This cholesterol metabolite, identified as Cholesterol-3,5,6-triol (S5) is one of 14 steroids/oxysterols identified in the lipid fraction of the secreted epidermal gel. The selective ­­action of S5 in this study suggests that it may have efficacy in cancer therapy as platelet inhibition has been shown to be important in the therapeutic control of cancer and in other chronic diseases including inflammation and related diseases.

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© 2024 Al-Hassan JM, et al. Distributed under Creative Commons CC-BY 4.0 Creative CommonsAttribution

How to cite this article

Al-Hassan JM, Afzal M, Oommen S, Liu YF, Khan M, Pace-Asciak C. Platelet Aggregation Modulation by a Cholesterol Derivative identifi ed in Skin Seccretions from Arabian Gulf Catfi sh (Arius bilineatus, Val.). J Biomed Res Environ Sci. 2024 Nov 30; 5(11): 1525-1530. doi: 10.37871/jbres2041, Article ID: JBRES2041, Available at: https://www.jelsciences.com/articles/jbres2041.pdf

Subject area(s)

Pharmacology

References

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