Covid-19 Research

Original Article

Cytotoxicity and Antibacterial Assessment of Zinc Ferrite and Cobalt Zinc Ferrite Nanoparticles with Siha, H9c2 and Hek 293 Cells

Journal of Biomedical Research & Environmental Sciences article abstract with citation details, DOI, publication dates, subject areas, full text links, and references.

View DOI Submit Manuscript

Article Details

Publication record, authors, dates, abstract, and full text access.

Open Access
Article Type Original Article
Subject Biology Group
OCLC JBRES Record
Leena Grace Beslin* and Arya AR
Issue: Volume5-Issue8
Pages: 1046-1056
Received: 2024-07-25
Accepted: 2024-08-30
Published: 2024-08-31

Abstract

The fast growing medical techniques and advances in medication system is very reliable for focusing targets according to their capability against different hallmarks. There is validation of particular activity to know whether it is effective against biology of cancer cells or not, if so then it should impair cancer growth and progression on its inhibition. The ferrite Nanoparticles (NPs) are the growing research area for biomedical applications. When Ferrite NPs interacts with any trivalent ion, cation, the spinel ferrite having chemical formula MFe2O4 (divalent cation) shows the category of the ferrite material. The ferrite materials have both ferromagnetic and semiconductor properties. In the present study we evaluated the anticancer and antibacterial property of zinc ferrite and cobalt zinc ferrite nanoparticles. Cytotoxicity of zinc ferrite and cobalt zinc ferrite was tested on uterine cancer cells (SiHa) which didn’t show a significant cytotoxicity at 5, 10, 20 and 50 µg/ml. This was evident from the results of neutral red assay and MTT assay. Treatment of H9c2 cells with zinc ferrite and cobalt zinc ferrite also showed the same result that the cell viability was not affected but cell morphology was altered at higher concentrations. The cytotoxic effect of Zinc ferrite and cobalt zinc ferrite was also analyzed in Human Embryonic Kidney cells (HEK 293 cells). All the tested concentrations didn’t affect the viability of HEK 293 cells. The present study also compared the antibacterial property of both ZFO and CZFO. Both compounds didn’t show antibacterial activity against both gram positive and negative bacteria.

FullText HTML FullText PDF DOI: 10.37871/jbres1986 Crossmark

Certificate of Publication

Certificate of Publication

Copyright

© 2024 Beslin LG, et al. Distributed under Creative Commons CC-BY 4.0 Creative CommonsAttribution

How to cite this article

Beslin LG, Arya AR. Cytotoxicity and Antibacterial Assessment of Zinc Ferrite and Cobalt Zinc Ferrite Nanoparticles with Siha, H9c2 and Hek 293 Cells. J Biomed Res Environ Sci. 2024 Aug 31; 5(8): 1046-1056. doi: 10.37871/jbres1986, Article ID: JBRES1986, Available at: https://www.jelsciences.com/articles/jbres1986.pdf

Subject area(s)

BiomedicineToxicology

References

  1. Imran A, Qamar HY, Ali Q, Naeem H, Riaz M, Amin S, Kanwal N, Ali F, Sabar MF, Nasir IA. Role of Molecular Biology in Cancer Treatment: A Review Article. Iran J Public Health. 2017 Nov;46(11):1475-1485. PMID: 29167765; PMCID: PMC5696686.
  2. Jiang BH, Liu LZ. PI3K/PTEN signaling in angiogenesis and tumorigenesis. Adv Cancer Res. 2009;102:19-65. doi: 10.1016/S0065-230X(09)02002-8. PMID: 19595306; PMCID: PMC2933405.
  3. Kong G, Braun RD, Dewhirst MW. Characterization of the effect of hyperthermia on nanoparticle extravasation from tumor vasculature. Cancer Res. 2001 Apr 1;61(7):3027-32. PMID: 11306483.
  4. Boersma YL, Chao G, Steiner D, Wittrup KD, Plückthun A. Bispecific designed ankyrin repeat proteins (DARPins) targeting epidermal growth factor receptor inhibit A431 cell proliferation and receptor recycling. J Biol Chem. 2011 Dec 2;286(48):41273-41285. doi: 10.1074/jbc.M111.293266. Epub 2011 Oct 6. PMID: 21979953; PMCID: PMC3308840.
  5. Boyer SW, Schroeder AV, Smith-Berdan S, Forsberg EC. All hematopoietic cells develop from hematopoietic stem cells through Flk2/Flt3-positive progenitor cells. Cell Stem Cell. 2011 Jul 8;9(1):64-73. doi: 10.1016/j.stem.2011.04.021. PMID: 21726834; PMCID: PMC4103692.
  6. Brisson M, Drolet M. Global elimination of cervical cancer as a public health problem. Lancet Oncol. 2019 Mar;20(3):319-321. doi: 10.1016/S1470-2045(19)30072-5. Epub 2019 Feb 19. PMID: 30795952.
  7. Cagle PT, Allen TC, Olsen RJ. Lung cancer biomarkers: present status and future developments. Arch Pathol Lab Med. 2013 Sep;137(9):1191-8. doi: 10.5858/arpa.2013-0319-CR. PMID: 23991729.
  8. Cakir BÖ, Adamson P, Cingi C. Epidemiology and economic burden of nonmelanoma skin cancer. Facial Plast Surg Clin North Am. 2012 Nov;20(4):419-22. doi: 10.1016/j.fsc.2012.07.004. PMID: 23084294.
  9. Cavallaro U, Christofori G. Cell adhesion and signalling by cadherins and Ig-CAMs in cancer. Nat Rev Cancer. 2004 Feb;4(2):118-32. doi: 10.1038/nrc1276. PMID: 14964308.
  10. Chauhan VP, Chen IX, Tong R, Ng MR, Martin JD, Naxerova K, Wu MW, Huang P, Boucher Y, Kohane DS, Langer R, Jain RK. Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy. Proc Natl Acad Sci U S A. 2019 May 28;116(22):10674-10680. doi: 10.1073/pnas.1819889116. Epub 2019 Apr 30. PMID: 31040208; PMCID: PMC6561160.
  11. Cheng N, Chytil A, Shyr Y, Joly A, Moses HL. Transforming growth factor-beta signaling-deficient fibroblasts enhance hepatocyte growth factor signaling in mammary carcinoma cells to promote scattering and invasion. Mol Cancer Res. 2008 Oct;6(10):1521-33. doi: 10.1158/1541-7786.MCR-07-2203. PMID: 18922968; PMCID: PMC2740918.
  12. Deshpande A, Sicinski P, Hinds PW. Cyclins and cdks in development and cancer: a perspective. Oncogene. 2005 Apr 18;24(17):2909-15. doi: 10.1038/sj.onc.1208618. PMID: 15838524.
  13. Esfandiarpour-Boroujeni S, Bagheri-Khoulenjani S, Mirzadeh H, Amanpour S. Fabrication and study of curcumin loaded nanoparticles based on folate-chitosan for breast cancer therapy application. Carbohydr Polym. 2017 Jul 15;168:14-21. doi: 10.1016/j.carbpol.2017.03.031. Epub 2017 Mar 10. PMID: 28457434.
  14. Grace BL. Antibacterial assessment of cuttlebone. Biomed J Sci & Tech Res 2022;47(4):007530. doi: 10.26717/BJSTR.2022.47.007530.
  15. Grasset F, Labhsetwar N, Li D, Park DC, Saito N, Haneda H, Cador O, Roisnel T, Mornet S, Duguet E, Portier J. Synthesis and magnetic characterization of zinc ferrite nanoparticles with different environments: powder, colloidal solution, and zinc ferrite− silica core− shell nanoparticles. Langmuir. 2002 Oct 15; 18 (21):8209-16. doi: 10.1021/la020322b.
  16. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR. Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. doi: 10.1038/nature05610. PMID: 17344846; PMCID: PMC2712719.
  17. Hartgrink HH, Jansen EP, van Grieken NC, van de Velde CJ. Gastric cancer. Lancet. 2009 Aug 8;374(9688):477-90. doi: 10.1016/S0140-6736(09)60617-6. Epub 2009 Jul 20. PMID: 19625077; PMCID: PMC4613761.
  18. Lee J, Xiao YY, Sun YY, Balderacchi J, Clark B, Desani J, Kumar V, Saverimuthu A, Win KT, Huang Y, Xu Y. Prevalence and characteristics of hereditary non-polyposis colorectal cancer (HNPCC) syndrome in immigrant Asian colorectal cancer patients. BMC Cancer. 2017 Dec 13;17(1):843. doi: 10.1186/s12885-017-3799-y. PMID: 29237405; PMCID: PMC5729240.
  19. Lemmon MA, Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell. 2010 Jun 25;141(7):1117-34. doi: 10.1016/j.cell.2010.06.011. PMID: 20602996; PMCID: PMC2914105.
  20. Li L, Tong R, Li M, Kohane DS. Self-assembled gemcitabine-gadolinium nanoparticles for magnetic resonance imaging and cancer therapy. Acta Biomater. 2016 Mar;33:34-9. doi: 10.1016/j.actbio.2016.01.039. Epub 2016 Jan 27. PMID: 26826531; PMCID: PMC4777675.
  21. Lowe SW, Cepero E, Evan G. Intrinsic tumour suppression. Nature. 2004 Nov 18;432(7015):307-15. doi: 10.1038/nature03098. PMID: 15549092.
  22. Maheswaran S, Haber DA. Circulating tumor cells: a window into cancer biology and metastasis. Curr Opin Genet Dev. 2010 Feb;20(1):96-9. doi: 10.1016/j.gde.2009.12.002. Epub 2010 Jan 12. PMID: 20071161; PMCID: PMC2846729.
  23. Mornet S, Vasseur S, Grasset F, Duguet E. Magnetic nanoparticle design for medical diagnosis and therapy. Journal of materials chemistry. 2004;14(14):2161-75. doi: 10.1039/B402025A.
  24. Mundekkad D, Cho WC. Nanoparticles in Clinical Translation for Cancer Therapy. Int J Mol Sci. 2022 Feb 1;23(3):1685. doi: 10.3390/ijms23031685. PMID: 35163607; PMCID: PMC8835852.
  25. Nigam A, Saini S, Singh B, Rai AK, Pawar SJ. Zinc doped magnesium ferrite nanoparticles for evaluation of biological properties viz antimicrobial, biocompatibility, and in vitro cytotoxicity. Materials Today Communications. 2022; 31:103632. doi: 10.1016/j.mtcomm.2022.103632.
  26. Oliver SA, Harris VG, Hamdeh HH, Ho JC. Large zinc cation occupancy of octahedral sites in mechanically activated zinc ferrite powders. Applied Physics Letters. 2000;76(19):2761-3. doi:10.1063/1.126467.
  27. Park BJ, Choi KH, Nam KC, Ali A, Min JE, Son H, Uhm HS, Kim HJ, Jung JS, Choi EH. Photodynamic Anticancer Activities of Multifunctional Cobalt Ferrite Nanoparticles in Various Cancer Cells. J Biomed Nanotechnol. 2015 Feb;11(2):226-35. doi: 10.1166/jbn.2015.2031. PMID: 26349298.
  28. Park EJ, Yi J, Chung KH, Ryu DY, Choi J, Park K. Oxidative stress and apoptosis induced by titanium dioxide nanoparticles in cultured BEAS-2B cells. Toxicol Lett. 2008 Aug 28;180(3):222-9. doi: 10.1016/j.toxlet.2008.06.869. Epub 2008 Jul 10. PMID: 18662754.
  29. Porkka N, Lahtinen L, Ahtiainen M, Böhm JP, Kuopio T, Eldfors S, Mecklin JP, Seppälä TT, Peltomäki P. Epidemiological, clinical and molecular characterization of Lynch-like syndrome: A population-based study. Int J Cancer. 2019 Jul 1;145(1):87-98. doi: 10.1002/ijc.32085. Epub 2019 Jan 7. PMID: 30575961.
  30. Sarala, E. &Naik, M. &Vinuth, & Reddy, Y. &Sujatha, H. Green synthesis of Lawsoniainermis-mediated zinc ferrite nanoparticles for magnetic studies and anticancer activity against breast cancer (MCF-7) cell lines. Journal of Materials Science: Materials in Electronics. 2020;31(3):1-8. doi: 10.1007/s10854-020-03394-8.
  31. Tanaka K, Makita M, Shimizugawa Y, Hirao K, Soga N. Structure and high magnetization of rapidly quenched zinc ferrite. Journal of Physics and Chemistry of Solids. 1998;59(9):1611-8. doi: 10.1016/S0022-3697(98)00078-X.
  32. Tong R, Kohane DS. New Strategies in Cancer Nanomedicine. Annu Rev Pharmacol Toxicol. 2016;56:41-57. doi: 10.1146/annurev-pharmtox-010715-103456. Epub 2015 Oct 28. PMID: 26514197.
  33. Sun S, Wang YH, Gao X, Wang HY, Zhang L, Wang N, Li CM, Xiong SQ. Current perspectives and trends in nanoparticle drug delivery systems in breast cancer: bibliometric analysis and review. Front Bioeng Biotechnol. 2023 Sep 12;11:1253048. doi: 10.3389/fbioe.2023.1253048. PMID: 37771575; PMCID: PMC10523396.
  34. Shenoy SD, Joy PA, Anantharaman MR. Effect of mechanical milling on the structural, magnetic and dielectric properties of co-precipitated ultrafine zinc ferrite. Journal of magnetism and magnetic materials. 2004;269(2):217-26. doi: 10.1016/S0304-8853(03)00596-1.
  35. Talmadge JE, Fidler IJ. AACR centennial series: the biology of cancer metastasis: historical perspective. Cancer Res. 2010 Jul 15;70(14):5649-69. doi: 10.1158/0008-5472.CAN-10-1040. Epub 2010 Jul 7. PMID: 20610625; PMCID: PMC4037932.
Publish with JBRES — Peer-reviewed, multidisciplinary Open Access with rapid review, DOI, and global visibility.
Double-Blind CrossRef DOI Discoverable
Submit Manuscript Membership