Cytotoxicity and Antibacterial Assessment of Zinc Ferrite and Cobalt Zinc Ferrite Nanoparticles with Siha, H9c2 and Hek 293 Cells

Leena Grace Beslin*; Arya AR

**Leena Grace Beslin* and Arya AR**

Volume5-Issue8
Dates: Received: 2024-07-25 | Accepted: 2024-08-30 | Published: 2024-08-31
Pages: 1046-1056

Abstract

The fast growing medical techniques and advances in medication system is very reliable for focusing targets according to their capability against different hallmarks. There is validation of particular activity to know whether it is effective against biology of cancer cells or not, if so then it should impair cancer growth and progression on its inhibition. The ferrite Nanoparticles (NPs) are the growing research area for biomedical applications. When Ferrite NPs interacts with any trivalent ion, cation, the spinel ferrite having chemical formula MFe2O4 (divalent cation) shows the category of the ferrite material. The ferrite materials have both ferromagnetic and semiconductor properties. In the present study we evaluated the anticancer and antibacterial property of zinc ferrite and cobalt zinc ferrite nanoparticles. Cytotoxicity of zinc ferrite and cobalt zinc ferrite was tested on uterine cancer cells (SiHa) which didn’t show a significant cytotoxicity at 5, 10, 20 and 50 µg/ml. This was evident from the results of neutral red assay and MTT assay. Treatment of H9c2 cells with zinc ferrite and cobalt zinc ferrite also showed the same result that the cell viability was not affected but cell morphology was altered at higher concentrations. The cytotoxic effect of Zinc ferrite and cobalt zinc ferrite was also analyzed in Human Embryonic Kidney cells (HEK 293 cells). All the tested concentrations didn’t affect the viability of HEK 293 cells. The present study also compared the antibacterial property of both ZFO and CZFO. Both compounds didn’t show antibacterial activity against both gram positive and negative bacteria.

FullText HTML FullText PDF DOI: 10.37871/jbres1986

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How to cite this article

Beslin LG, Arya AR. Cytotoxicity and Antibacterial Assessment of Zinc Ferrite and Cobalt Zinc Ferrite Nanoparticles with Siha, H9c2 and Hek 293 Cells. J Biomed Res Environ Sci. 2024 Aug 31; 5(8): 1046-1056. doi: 10.37871/jbres1986, Article ID: JBRES1986, Available at: https://www.jelsciences.com/articles/jbres1986.pdf

Subject area(s)

Biomedicine

Toxicology

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