Design and Preparation of a Novel Antibacterial Hydrogel based on Maleimide-Thiol Conjugation

Song Jiang*; Yue Liu; Taoqing Wang; Yuan Gu; Yige Luo

**Song Jiang*, Yue Liu, Taoqing Wang, Yuan Gu and Yige Luo**

Volume4-Issue6
Dates: Received: 2023-06-04 | Accepted: 2023-06-12 | Published: 2023-06-13
Pages: 1002-1010

Abstract

This article synthesized and characterized a novel antibacterial hydrogel, which is formed using maleimide–thiol conjugation. Two precursors chitosan functionalized thiol groups and dextran functionalized maleimide groups prepared and characterized by Nuclear Magnetic Resonance (NMR). Key features of the hydrogel, such as gelation time, swelling behavior, viscoelastic properties, and degradation rate, were thoroughly examined. From gelation time result, we found that formed hydrogel gelation time could be changed with diffident weight percentage of precursors. Based on references, we found the best formular for the gelation and it was also determined for other studies. The swelling study indicated hydrogel has good flexibility and the degradation test indicated hydrogel is biodegradable. The viscoelastic test indicated hydrogel is an elastic solid. Given these attributes, this novel hydrogel has significant potential for use in various biomedical applications. Finally, colony-counting tests revealed that the hydrogel has an excellent antibacterial ability. Given these attributes, this novel hydrogel has significant potential for use in various biomedical applications.

FullText HTML FullText PDF DOI: 10.37871/jbres1761

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How to cite this article

Jiang S, Liu Y, Wang T, Gu Y, Luo Y. Design and Preparation of a Novel Antibacterial Hydrogel based on Maleimide-Thiol Conjugation. 2023 June 13; 4(6): 1002-1010. doi: 10.37871/jbres1761, Article ID: JBRES1761, Available at: https:// www.jelsciences.com/articles/jbres1761.pdf

Subject area(s)

Biochemistry

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