Covid-19 Research

Research Article

Design and Preparation of a Novel Antibacterial Hydrogel based on Maleimide-Thiol Conjugation

Journal of Biomedical Research & Environmental Sciences article abstract with citation details, DOI, publication dates, subject areas, full text links, and references.

View DOI Submit Manuscript

Article Details

Publication record, authors, dates, abstract, and full text access.

Open Access
Article Type Research Article
Subject Biology Group
OCLC JBRES Record
Song Jiang*, Yue Liu, Taoqing Wang, Yuan Gu and Yige Luo
Issue: Volume4-Issue6
Pages: 1002-1010
Received: 2023-06-04
Accepted: 2023-06-12
Published: 2023-06-13

Abstract

This article synthesized and characterized a novel antibacterial hydrogel, which is formed using maleimide–thiol conjugation. Two precursors chitosan functionalized thiol groups and dextran functionalized maleimide groups prepared and characterized by Nuclear Magnetic Resonance (NMR). Key features of the hydrogel, such as gelation time, swelling behavior, viscoelastic properties, and degradation rate, were thoroughly examined. From gelation time result, we found that formed hydrogel gelation time could be changed with diffident weight percentage of precursors. Based on references, we found the best formular for the gelation and it was also determined for other studies. The swelling study indicated hydrogel has good flexibility and the degradation test indicated hydrogel is biodegradable. The viscoelastic test indicated hydrogel is an elastic solid. Given these attributes, this novel hydrogel has significant potential for use in various biomedical applications. Finally, colony-counting tests revealed that the hydrogel has an excellent antibacterial ability. Given these attributes, this novel hydrogel has significant potential for use in various biomedical applications.

FullText HTML FullText PDF DOI: 10.37871/jbres1761 Crossmark

Certificate of Publication

Certificate of Publication

Copyright

© 2023 Jiang S, et al. Distributed under Creative Commons CC-BY 4.0 Creative CommonsAttribution

How to cite this article

Jiang S, Liu Y, Wang T, Gu Y, Luo Y. Design and Preparation of a Novel Antibacterial Hydrogel based on Maleimide-Thiol Conjugation. 2023 June 13; 4(6): 1002-1010. doi: 10.37871/jbres1761, Article ID: JBRES1761, Available at: https:// www.jelsciences.com/articles/jbres1761.pdf

Subject area(s)

Biochemistry

References

  1. Kabiri K, Omidian H, Zohuriaan‐Mehr M, Doroudiani S. Superabsorbent hydrogel composites and nanocomposites: A review. Polymer Composites. 2011;32(2):277-289. doi: 10.1002/pc.21046.
  2. Kang D, Zhao J, Tyler Dick C, Liu X, Bian Z, Kirkpatrick SW, Lin CY. Probabilistic risk analysis of unit trains versus manifest trains for transporting hazardous materials. Accid Anal Prev. 2023 Mar;181:106950. doi: 10.1016/j.aap.2022.106950. Epub 2022 Dec 31. PMID: 36592490.
  3. Kang D, Levin MW. Maximum-stability dispatch policy for shared autonomous vehicles. Transportation Research Part B: Methodological. 2021;148:132-151. doi: 10.1016/j.trb.2021.04.011.
  4. Kang D, Hu F, Levin M. Impact of automated vehicles on traffic assignment, mode split, and parking behavior. Transportation Research Part D: Transport and Environment. 2022;104:103200. doi: 10.1016/j.trd.2022.103200.
  5. Ni L, Tang C, Wang Y, Wan J, Charles MG, Zhang Z, Li C, Zeng R, Jin Y, Song P, Wei M, Li B, Zhang J, Wu Z. Construction of a miRNA-Based Nomogram Model to Predict the Prognosis of Endometrial Cancer. J Pers Med. 2022 Jul 17;12(7):1154. doi: 10.3390/jpm12071154. PMID: 35887651; PMCID: PMC9318842.
  6. Liu Y, Sun Y, Guo Y, Shi X, Chen X, Feng W, Wu LL, Zhang J, Yu S, Wang Y, Shi Y. An Overview: The Diversified Role of Mitochondria in Cancer Metabolism. Int J Biol Sci. 2023 Jan 16;19(3):897-915. doi: 10.7150/ijbs.81609. PMID: 36778129; PMCID: PMC9910000.
  7. Chen Y, Li C, Wang N, Wu Z, Zhang J, Yan J, Wei Y, Peng Q, Qi J. Identification of LINC00654-NINL Regulatory Axis in Diffuse Large B-Cell Lymphoma In Silico Analysis. Front Oncol. 2022 May 26;12:883301. doi: 10.3389/fonc.2022.883301. PMID: 35719990; PMCID: PMC9204339.
  8. Liu Y, Wang Y, Yang Y, Weng L, Wu Q, Zhang J, Zhao P, Fang L, Shi Y, Wang P. Emerging phagocytosis checkpoints in cancer immunotherapy. Signal Transduct Target Ther. 2023 Mar 7;8(1):104. doi: 10.1038/s41392-023-01365-z. PMID: 36882399; PMCID: PMC9990587.
  9. Liu J, Zhang J, Beeraka NM, Chen K, Sinelnikov MY, Manogaran P, Bannimath G, Nikolenko VN, Fan R. Perspectives on the nanocarriers with miRNAs for targeting melanoma stemness through epigenetic regulation. Pigment Cell Melanoma Res. 2023 May-Jul;36(3-4):268-287. doi: 10.1111/pcmr.13081. Epub 2023 Feb 2. PMID: 36691113.
  10. Ren X, Wang N, Zhou Y, Song A, Jin G, Li Z, Luan Y. An injectable hydrogel using an immunomodulating gelator for amplified tumor immunotherapy by blocking the arginase pathway. Acta Biomater. 2021 Apr 1;124:179-190. doi: 10.1016/j.actbio.2021.01.041. Epub 2021 Jan 30. PMID: 33524560.
  11. Kodavaty J. Poly (vinyl alcohol) and hyaluronic acid hydrogels as potential biomaterial systems-A comprehensive review. Journal of Drug Delivery Science and Technology. 2022;103298. doi: 10.1016/j.jddst.2022.103298.
  12. Wang H, Xu Z, Zhao M, Liu G, Wu J. Advances of hydrogel dressings in diabetic wounds. Biomater Sci. 2021 Mar 10;9(5):1530-1546. doi: 10.1039/d0bm01747g. PMID: 33433534.
  13. Jiang S, Liu Y, Wang T. Investigation of a novel biocompatible fast-gelling hydrogel for neurodegenerative diseases. Biomedical Journal of Scientific & Technical Research. 2023;50(3):1149-1157. doi: 10.26717/BJSTR.2023.50.007951.
  14. Kalhapure A, Kumar R, Singh VP, Pandey D. Hydrogels: A boon for increasing agricultural productivity in water-stressed environment. Current Science. 2016;1773-1779.
  15. Patra SK, Poddar R, Brestic M, Acharjee PU, Bhattacharya P, Sengupta S, Pal P, Bam N, Biswas B, Barek V. Prospects of hydrogels in agriculture for enhancing crop and water productivity under water deficit condition. International Journal of Polymer Science. 2022;2022. doi: 10.1155/2022/4914836.
  16. Qiu X, Hu S. "Smart" Materials Based on Cellulose: A Review of the Preparations, Properties, and Applications. Materials (Basel). 2013 Feb 28;6(3):738-781. doi: 10.3390/ma6030738. PMID: 28809338; PMCID: PMC5512797.
  17. Maitra J, Shukla VK. Cross-linking in hydrogels: A review. Am J Polym Sci. 2014;4(2):25-31. doi: 10.5923/j.ajps.20140402.01.
  18. Hu W, Wang Z, Xiao Y, Zhang S, Wang J. Advances in crosslinking strategies of biomedical hydrogels. Biomater Sci. 2019 Feb 26;7(3):843-855. doi: 10.1039/c8bm01246f. PMID: 30648168.
  19. Bhatia S. Natural polymers vs. synthetic polymer. Natural Polymer Drug Delivery Systems: Nanoparticles, Plants, and Algae. 2016. p.95-118.
  20. Chen S, Chen S, Jiang S, Mo Y, Tang J, Ge Z. Synthesis and characterization of siloxane sulfobetaine antimicrobial agents. Surface Science. 2011;605(11-12):L25-L28. doi: 10.1016/j.susc.2011.03.013.
  21. Chen S, Chen S, Jiang S, Mo Y, Luo J, Tang J, Ge Z. Study of zwitterionic sulfopropylbetaine containing reactive siloxanes for application in antibacterial materials. Colloids Surf B Biointerfaces. 2011 Jul 1;85(2):323-9. doi: 10.1016/j.colsurfb.2011.03.004. Epub 2011 Mar 29. PMID: 21450443.
  22. Chen S, Chen S, Jiang S, Xiong M, Luo J, Tang J, Ge Z. Environmentally friendly antibacterial cotton textiles finished with siloxane sulfopropylbetaine. ACS Appl Mater Interfaces. 2011 Apr;3(4):1154-62. doi: 10.1021/am101275d. Epub 2011 Mar 28. PMID: 21417413.
  23. Chen S, Chen S, Jiang S, Xiong M, Luo J, Tang J, Ge Z. Environmentally friendly antibacterial cotton textiles finished with siloxane sulfopropylbetaine. ACS Appl Mater Interfaces. 2011 Apr;3(4):1154-62. doi: 10.1021/am101275d. Epub 2011 Mar 28. PMID: 21417413.
  24. Oz Y, Sanyal A. The Taming of the Maleimide: Fabrication of Maleimide-Containing 'Clickable' Polymeric Materials. Chem Rec. 2018 Jun;18(6):570-586. doi: 10.1002/tcr.201700060. Epub 2017 Dec 29. PMID: 29286198.
  25. Jiang S, Zhang T. Studies of a biocompatible maleimide-modified dextran and hyaluronic acid hydrogel system. Fine Chemical Engineering. 2023;100-109. doi: 10.37256/fce.4220232705.
  26. Hall DJ, Van Den Berghe HM, Dove AP. Synthesis and post‐polymerization modification of maleimide‐containing polymers by ‘thiol‐ene’click and Diels-Alder chemistries. Polymer International. 2011;60(8):1149-1157.
  27. Guo X, Wang L, Wang S, Li Y, Zhang F, Song B, Zhao W. Syntheses of new chlorin derivatives containing maleimide functional group and their photodynamic activity evaluation. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4078-81. doi: 10.1016/j.bmcl.2015.08.036. Epub 2015 Aug 18. PMID: 26306981.
  28. Oz Y, Barras A, Sanyal R, Boukherroub R, Szunerits S, Sanyal A. Functionalization of Reduced Graphene Oxide via Thiol-Maleimide "Click" Chemistry: Facile Fabrication of Targeted Drug Delivery Vehicles. ACS Appl Mater Interfaces. 2017 Oct 4;9(39):34194-34203. doi: 10.1021/acsami.7b08433. Epub 2017 Sep 21. PMID: 28905618.
  29. Zeng Z , Mo XM , He C , Morsi Y , El-Hamshary H , El-Newehy M . An in situ forming tissue adhesive based on poly(ethylene glycol)-dimethacrylate and thiolated chitosan through the Michael reaction. J Mater Chem B. 2016 Sep 7;4(33):5585-5592. doi: 10.1039/c6tb01475e. Epub 2016 Aug 8. PMID: 32263355.
  30. Smyth DG, Nagamatsu A, Fruton JS. Some reactions of N-ethylmaleimide1. Journal of the American Chemical Society. 1960;82(17):4600-4604.
Publish with JBRES — Peer-reviewed, multidisciplinary Open Access with rapid review, DOI, and global visibility.
Double-Blind CrossRef DOI Discoverable
Submit Manuscript Membership