Effects of the Mechanism of Traditional Chinese Medical Prescription-Yiqihuoxue Formula on Vasculopathy with Systemic Sclerosis

Yiyun Xue; Yinhuan Zhao*

Yiyun Xue and Yinhuan Zhao*

Volume3-Issue11
Dates: Received: 2022-11-15 | Accepted: 2022-11-27 | Published: 2022-11-28
Pages: 1408-1412

Abstract

Vasculopathy is a prevalent complication that may appear in the early stage of Systemic Sclerosis (SSc). Traditional Chinese medical prescription-Yiqihuoxue formula (YQHX) has been used as a therapeutic option for SSc in our department, which has acquired a significant treatment effect. We interrogated the role of the YQHX on Vasculopathy with SSc by investigating its effects on the HDMECs from H2O2 injury. The viability of the HDMECs which were induced by H2O2 and then impacted by the YQHX was noticeably more than that of the H2O2-induced HDMECs, while the apoptosis cell percentage was significantly lower. The YQHX could promote cell proliferation and inhibit apoptosis which meant it could protect HDMECs from H2O2 injury. And the tube formation assay shown that the YQHX may have a promoted effects on angiogenic properties of HDMECs. Our data demonstrated that the YQHX is helpful on alleviating vasculopathy. These data help in directing personalized therapeutic approaches in SSc.

FullText HTML FullText PDF DOI: 10.37871/jbres1612

Certificate of Publication

Copyright

How to cite this article

Xue Y, Zhao Y. Effects of the Mechanism of Traditional Chinese Medical Prescription-Yiqihuoxue Formula on Vasculopathy with Systemic Sclerosis. 2022 Nov 28; 3(11): 1408-1412. doi: 10.37871/jbres1612, Article ID: JBRES1612, Available at: https://www.jelsciences.com/articles/jbres1612.pdf

Subject area(s)

Vascular Medicine

Dermatology

References

Kowal-Bielecka O, Fransen J, Avouac J, Becker M, Kulak A, Allanore Y, Distler O, Clements P, Cutolo M, Czirjak L, Damjanov N, Del Galdo F, Denton CP, Distler JHW, Foeldvari I, Figelstone K, Frerix M, Furst DE, Guiducci S, Hunzelmann N, Khanna D, Matucci-Cerinic M, Herrick AL, van den Hoogen F, van Laar JM, Riemekasten G, Silver R, Smith V, Sulli A, Tarner I, Tyndall A, Welling J, Wigley F, Valentini G, Walker UA, Zulian F, Müller-Ladner U; EUSTAR Coauthors. Update of EULAR recommendations for the treatment of systemic sclerosis. Ann Rheum Dis. 2017 Aug;76(8):1327-1339. doi: 10.1136/annrheumdis-2016-209909. Epub 2016 Nov 9. PMID: 27941129.
Gabrielli A, Avvedimento EV, Krieg T. Scleroderma. The New England Journal Of Medicine. 2009;360(19):1989–2003.
Asano Y, Sato S. Vasculopathy in scleroderma. Semin Immunopathol. 2015 Sep;37(5):489-500. doi: 10.1007/s00281-015-0505-5. Epub 2015 Jul 8. PMID: 26152638.
Smith V, Herrick AL, Ingegnoli F, Damjanov N, De Angelis R, Denton CP, Distler O, Espejo K, Foeldvari I, Frech T, Garro B, Gutierrez M, Gyger G, Hachulla E, Hesselstrand R, Iagnocco A, Kayser C, Melsens K, Müller-Ladner U, Paolino S, Pizzorni C, Radic M, Riccieri V, Snow M, Stevens W, Sulli A, van Laar JM, Vonk MC, Vanhaecke A, Cutolo M; EULAR Study Group on Microcirculation in Rheumatic Diseases and the Scleroderma Clinical Trials Consortium Group on Capillaroscopy. Standardisation of nailfold capillaroscopy for the assessment of patients with Raynaud's phenomenon and systemic sclerosis. Autoimmun Rev. 2020 Mar;19(3):102458. doi: 10.1016/j.autrev.2020.102458. Epub 2020 Jan 10. PMID: 31927087.
Chifflot H, Fautrel B, Sordet C, Chatelus E, Sibilia J. Incidence and prevalence of systemic sclerosis: a systematic literature review. Semin Arthritis Rheum. 2008 Feb;37(4):223-35. doi: 10.1016/j.semarthrit.2007.05.003. Epub 2007 Aug 9. PMID: 17692364.
Truchetet ME, Brembilla NC, Chizzolini C. Current Concepts on the Pathogenesis of Systemic Sclerosis. Clin Rev Allergy Immunol. 2021 Sep 6. doi: 10.1007/s12016-021-08889-8. Epub ahead of print. PMID: 34487318.
Smeets RL, Kersten BE, Joosten I, Kaffa C, Alkema W, Koenen HJPM, Vonk MC. Diagnostic profiles for precision medicine in systemic sclerosis; stepping forward from single biomarkers towards pathophysiological panels. Autoimmun Rev. 2020 May;19(5):102515. doi: 10.1016/j.autrev.2020.102515. Epub 2020 Mar 12. PMID: 32173517.
Khader A, Valiaveetil B, Nalini SD, George B, Sasidharanpillai S, Nazeer MMA, Manikath N. Effect of monthly cyclophosphamide pulses on skin sclerosis in systemic sclerosis. Indian J Dermatol Venereol Leprol. 2021 Sep-Oct;87(5):728-731. doi: 10.25259/IJDVL_796_19. PMID: 34379952.
Hou YZ, Zhao GR, Yang J, Yuan YJ, Zhu GG, Hiltunen R. Protective effect of Ligusticum chuanxiong and Angelica sinensis on endothelial cell damage induced by hydrogen peroxide. Life Sci. 2004 Aug 20;75(14):1775-86. doi: 10.1016/j.lfs.2004.05.005. PMID: 15268976.
Wang XH, Zhang JQ, Kong Q, Tu WZ, Chen LM, Zhao YH. Application of integrated traditional chinese and western medicine in treatment of systemic sclerosis: A case report. Explore (NY). 2022 Jun 7:S1550-8307(22)00077-5. doi: 10.1016/j.explore.2022.06.001. Epub ahead of print. PMID: 35697584.
Dongdong C, Wenzhen T, Lei W, Jiaqian Z, Ling Y. Follow-up of long-term efficacy of comprehensive stage therapy of traditional Chinese and western medicine in the treatment of systemic scleroderma. Chinese Journal of Dermatology and Venereal Diseases of Integrated Traditional and Western Medicine. 2015,14(6):364-367.
Ho JH, Hong CY. Salvianolic acids: small compounds with multiple mechanisms for cardiovascular protection. J Biomed Sci. 2011 May 11;18(1):30. doi: 10.1186/1423-0127-18-30. PMID: 21569331; PMCID: PMC3113734.
Chan P, Chen YC, Lin LJ, Cheng TH, Anzai K, Chen YH, Liu ZM, Lin JG, Hong HJ. Tanshinone IIA Attenuates H₂O₂ -induced injury in human umbilical vein endothelial cells. Am J Chin Med. 2012;40(6):1307-19. doi: 10.1142/S0192415X12500966. PMID: 23227799.
Han R, Tang F, Lu M, Xu C, Hu J, Mei M, Wang H. Astragalus polysaccharide ameliorates H2O2-induced human umbilical vein endothelial cell injury. Mol Med Rep. 2017 Jun;15(6):4027-4034. doi: 10.3892/mmr.2017.6515. Epub 2017 Apr 26. PMID: 28487940; PMCID: PMC5436204.
Allanore Y, Distler O, Matucci-Cerinic M, Denton CP. Review: Defining a Unified Vascular Phenotype in Systemic Sclerosis. Arthritis Rheumatol. 2018 Feb;70(2):162-170. doi: 10.1002/art.40377. Epub 2018 Jan 22. PMID: 29145709.
Morrisroe K, Hansen D, Stevens W, Sahhar J, Ngian GS, Hill C, Roddy J, Walker J, Proudman S, Nikpour M. Gastric antral vascular ectasia in systemic sclerosis: a study of its epidemiology, disease characteristics and impact on survival. Arthritis Res Ther. 2022 May 10;24(1):103. doi: 10.1186/s13075-022-02790-1. PMID: 35538587; PMCID: PMC9087964.
Mecoli CA, Perin J, Van Eyk JE, Zhu J, Fu Q, Allmon AG, Rao Y, Zeger S, Wigley FM, Hummers LK, Shah AA. Vascular biomarkers and digital ulcerations in systemic sclerosis: results from a randomized controlled trial of oral treprostinil (DISTOL-1). Clin Rheumatol. 2020 Apr;39(4):1199-1205. doi: 10.1007/s10067-019-04863-0. Epub 2019 Dec 19. PMID: 31858338; PMCID: PMC8211019.
Michiels C. Endothelial cell functions. Journal of Cellular Physiology. 2003;196(3):430-443. doi: 10.1002/jcp.10333
Soluble guanylate cyclase stimulation fosters angiogenesis and blunts myofibroblast-like features of systemic sclerosis endothelial cells. Rheumatology (Oxford, England), keac433. Advance online publication.
Guiducci S, Giacomelli R, Cerinic MM. Vascular complications of scleroderma. Autoimmunity Reviews. 2007;6(8):520-523.
Romano E, Rosa I, Fioretto BS, Giuggioli D, Manetti M, Matucci-Cerinic M. Soluble guanylate cyclase stimulation fosters angiogenesis and blunts myofibroblast-like features of systemic sclerosis endothelial cells. Rheumatology (Oxford). 2022 Jul 28:keac433. doi: 10.1093/rheumatology/keac433. Epub ahead of print. PMID: 35900177.