Mechanisms of PD-L1 Regulation in Tumor Immune Ecosystem

Fatima Bangash*; Sabiha Alia; Rabia Gul

**Fatima Bangash*, Sabiha Alia and Rabia Gul**

Volume3-Issue8
Dates: Received: 2022-07-15 | Accepted: 2022-07-30 | Published: 2022-08-09
Pages: 867-879

Abstract

PD-1 (Programmed Death Receptor-1) is a cell membrane protein found on Cytotoxic T cells (CTLs) surface. An abundantly expressed type I transmembrane protein in healthy tissues, Programmed Death-Ligand 1 (PD-L1), has a molecular mass of 40 kDa. The extracellular binding of the proteins PD-1 and PD-L1 prevents the development of autoimmune disorders by suppressing the activation of CTLs under normal physiological conditions. It has been shown that cancer cells can avoid immune monitoring by increasing PD-1/PD-1-mediated CTL inactivation in melanoma, lung cancer, renal cell carcinoma, and other malignant tumors. PD-L1 expression regulation has been described in recent years from the standpoint of gene amplification, chromatin modification, post-transcription and transcription modification, translation, and post-translational modification. Anti-PD-1 immunotherapy has demonstrated promising results in treating several cancers, including breast, lung, and prostate cancers. This review aims to present the most recent research findings in PD-L1 regulation in cancer cells. A tumor immunotherapy strategy targeting PD-1 and PD-L1 is expected to be useful.

FullText HTML FullText PDF DOI: 10.37871/jbres1525

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How to cite this article

Bangash F, Alia S, Gul R. Mechanisms of PD-L1 Regulation in Tumor Immune Ecosystem. J Biomed Res Environ Sci. 2022 Aug 09; 3(8): 867-879. doi: 10.37871/jbres1525, Article ID: JBRES1525, Available at: https://www.jelsciences.com/articles/jbres1525.pdf

Subject area(s)

Molecular Biology

Genetics

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