Importance of Organophosphorus Compounds in Medicinal Chemistry Field

Petri A Turhanen*

Petri A Turhanen*

Volume3-Issue2
Dates: Received: 2022-02-11 | Accepted: 2022-02-21 | Published: 2022-02-24
Pages: 195-197

Abstract

Organophosphorus chemistry has a crucial role in the field of drug research [1]. As generally well known, the Adenosine Triphosphate (ATP) plays a key role in the energy processes in all living cells of mammals. There are also natural phosphorus containing organic compound, Phosphocitrate (PC), found in mammalian mitochondria, likely produced by cytosolic phosphorylation of citrate, and which has important role in calcium metabolism, e.g. inhibiting hydroxyapatite precipitation in cells [2-4].

FullText HTML FullText PDF DOI: 10.37871/jbres1421

Certificate of Publication

Copyright

How to cite this article

Turhanen PA. Importance of Organophosphorus Compounds in Medicinal Chemistry Field. J Biomed Res Environ Sci. 2022 Feb 24; 3(2): 195-197. doi: 10.37871/jbres1421, Article ID: JBRES1421, Available at: https://www.jelsciences.com/articles/jbres1421.pdf

Subject area(s)

Pharmaceutica Analytica Acta

Pharmacology

References

Tajti Á, Keglevich G. The importance of organophosphorus compounds as biologically active agents". Organophosphorus Chemistry: Novel Developments, edited by György Keglevich, Berlin, Boston: De Gruyter. 2018:53-65. doi: 10.1515/9783110535839-003
Turhanen PA, Demadis KD, Peräniemi S, Vepsäläinen JJ. A novel strategy for the preparation of naturally occurring phosphocitrate and its partially esterified derivatives. J Org Chem. 2007;72(4):1468-1471. doi: 10.1021/jo061709c
Moro L, Stagni N, Luxich E, Sallis JD, de Bernard B. Evidence in vitro for an enzymatic synthesis of phosphocitrate. Biochem Biophys Res Commun. 1990 Jul 16;170(1):251-258. doi: 10.1016/0006-291x(90)91267-v. PMID: 2372290.
Howard JE. Studies on urinary stone formation: A saga of clinical investigation. Johns Hopkins Med J. 1976 Dec;139(6):239-52. PMID: 12399.
Turhanen PA, Demadis KD, Kafarski P. Editorial: Phosphonate chemistry in drug design and development. Front Chem. 2021. doi: 10.3389/fchem.2021.695128
Groaz E, De Jonghe S. Overview of biologically active nucleoside phosphonates. Front Chem. 2021;8:616863. doi: 10.3389/fchem.2020.616863
Sevrain CM, Berchel M, Couthon H, Jaffrès PA. Phosphonic acid: Preparation and applications. J Org Chem. 2017;13:2186–2213. doi: 10.3762/bjoc.13.219
Wilkens H, Sester M. Treatment of cytomegalovirus infection with Cidofovir and CMV immune globulin in a lung transplant recipient. Case Rep Transplant. 2016;2016:4560745. doi: 10.1155/2016/4560745
Al Mosawi AJ. Remdesivir research progress: An overview of the emerging evidence. J Biomed Res Environ Sci. 2020;1(6):216-218. doi: 10.37871/jbres1146
Graham R, Russell G. Bisphosphonates: The first 40 years. Bone. 2011;49(1):2-19. doi: 10.1016/j.bone.2011.04.022
Park J, Pandya VR, Ezekiel SJ, Berghuis AM. Phosphonate and bisphosphonate inhibitors of farnesyl pyrophosphate synthases: a structure-guided perspective. Front Chem. 2021:612728. doi: 10.3389/fchem.2020.612728
Popov K, Oshchepkov M, Tkachenko S, Sergienko V, Oshchepkov A. Bisphosphonates: Synthesis, structures, properties, medical and industrial applications. J Mol Liq. 2022. doi: 10.1016/j.molliq.2022.118619
Turhanen PA, Vepsäläinen JJ, Peräniemi S. Advanced material and approach for metal ions removal from aqueous solutions. Sci Rep. 2015;5:8992. doi: 10.1038/srep08992
Haluska O, Rahmani A, Salami A, Turhanen P, Vepsäläinen J, Lappalainen R, Lehto VP, Riikonen J. Plant-based nanostructured silicon carbide modified with bisphosphonates for metal adsorption. Microporous Mesoporous Mater. 2021;324:111294. doi: 10.1016/j.micromeso.2021.111294
Thapa R, Nissinen T, Turhanen P, Määttä J, Vepsäläinen J, Lehto VP, Riikonen J. Bisphosphonate modified mesoporous silicon for scandium adsorption. Microporous Mesoporous Mater. 2020;296:109980. doi: 10.1016/j.micromeso.2019.109980
Thapa R, Rahmani A, Turhanen P, Taskinen A, Nissinen T, Neitola R, Vepsäläinen J, Lehto VP, Riikonen J. Recovery of uranium with bisphosphonate modified mesoporous silicon. Sep Purif. 2021;272:118913. doi: 10.1016/j.seppur.2021.118913
Mönkkönen H, Auriola S, Lehenkari P, Kellinsalmi M, Hassinen IE, Vepsäläinen J, Mönkkönen J. A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates. Br J Pharmacol. 2006 Feb;147(4):437-445. doi: 10.1038/sj.bjp.0706628. PMID: 16402039; PMCID: PMC1616989.
Malwal SR, Dowd B, Feng X, Turhanen P, Shin C, Yao J, Kim BK, Baig N, Zhou T, Bansal S, Khade RL, Zhang Y, Oldfield E. Bisphosphonate-generated ATP-analogs inhibit cell signaling pathways. J Am Chem Soc. 2018;140:7568–7578. doi: 10.1021/jacs.8b02363
Turhanen PA. Synthesis of a biologically important adenosine triphosphate analogue, ApppD. ACS Omega 2017;2(6):2835-2838. doi: 10.1021/acsomega.7b00531
Puljula E, Turhanen PA. Semi-preparative high-performance countercurrent chromatography method for the purification of chemically synthesized ATP analogue, ApppI. J. Chromatogr. B: Anal. Technol Biomed Life Sci. 2017;1063:180-182. doi: 10.1016/j.jchromb.2017.08.038