Pharmaceutical & Clinical Research
Section Editors
Amgad M Rabie
Choon Fu Goh
Dianping Tang
Ferdinando Calabria
Gerald H. Lushington
Hanaa Salem Saleh Gazwi
Hanganu Daniela
Jesper Bo Nielsen
Károly Héberger
Klemens Wild
Liliana Mititelu Tartau
Mir Monir Hossain
Mohammad F. Bayan
Morshed Nasir
Mostafa Mahmoud Gouda
Omkulthom Mohamed Al kamaly
Qian Zhong Ming
Tadeusz Hryniewicz
Turhanen Petri Antero
Wasana K Sumanasekera
Research Topics in this Section
Clinical Trials
17
Clinical TrialsThese topics are filtered from our journals helping to discover the community within the widespread of multi-discip…
Nuclear Medicine
7
Nuclear MedicineThese topics are filtered from our journals helping to discover the community within the widespread of multi-disci…
Pharmaceutica Analytica Acta
22
Pharmaceutica Analytica ActaThese topics are filtered from our journals helping to discover the community within the widespread of…
Pharmacology
52
PharmacologyThese topics are filtered from our journals helping to discover the community within the widespread of multi-disciplin…
Therapeutics
25
TherapeuticsThese topics are filtered from our journals helping to discover the community within the widespread of multi-disciplin…
Recent Articles
50 articles
Open Access
Review Article 22 Apr 2026
Therapeutic Strategies in Acute Myeloid Leukemia: Current Advances and Future Directions
Acute Myeloid Leukemia (AML) is a clinically aggressive and molecularly heterogeneous hematologic malignancy characterized by poor long-term outcomes, largely due to high rates of relapse and therapeutic resistance. For …
15 Views 56 Downloads
Open Access
Case Report 31 Mar 2026
Combined Dopaminergic Drugs to Treat Pyoderma Gangrenosum
Monoclonal antibody therapy directed against certain pathways leading to the eventual cellular immune reaction to an irritating agent has been a mainstay of therapy for many pathological conditions considered autoimmune …
9 Views 51 Downloads
Open Access
Research Article 09 Mar 2026
Formulation Development, Analytical Validation and In vitro Assessment of a Generic Lymecycline 408 mg Hard Capsule
This study documents the stepwise development and evaluation of a generic Lymecycline 408 mg hard gelatin capsule manufactured locally in Pakistan. The formulation process began with the selection of suitable pharmacopei…
10 Views 62 Downloads
Open Access
Research Article 03 Feb 2026
Coenzyme Q10 Nanoemulsions Enhance Bioavailability in Drosophila Melanogaster Larvae
Coenzyme Q10 (CoQ10) is a vital lipophilic molecule involved in mitochondrial energy production and antioxidant defense mechanisms. Despite its therapeutic potential in aging, cardiovascular, and neurodegenerative diseas…
5 Views 95 Downloads 1 Citation
Open Access
Letter 20 Jan 2026
Poly-De-Prescribing to Treat the Iatrogenic Epidemic of Polypharmacy - A Major Public Health Challenge
28 Views 69 Downloads
Open Access
Research Article 19 Jan 2026
Novel Oncoplastic Surgery for Long-Term Outcome and Prediction of Breast Cancer Survival beyond Serial Axillary Dissection – A Prospective Study
Study background: Axillary Lymph Node Dissection (ALND) maintains therapeutic value in high-risk Breast Cancer (BC), while sentinel lymph node biopsy is the standard for staging early-stage, clinically node-negative case…
40 Views 75 Downloads
Open Access
Research Article 08 Nov 2025
Refluward® HA: Efficacy and Safety in Patients with Gastro-Esophageal Diseases
The physiological activity of stomach and esophagus is often impaired by the onset of various diseases such as Gastroesophageal Reflux Disease (GERD), esophagitis, hiatal hernia, tertiary esophageal waves, Barrett’s es…
127 Views 77 Downloads
Open Access
Perspective 23 Oct 2025
Quercetin Analogs as Cancer Chemopreventive Agents: A New Perspective
Quercetin is a flavonoid-type chemical molecule found in many people's daily diets. Previous research has shown that quercetin offers a range of benefits, including anti-inflammatory, antioxidant, and cancer-prevention p…
760 Views 80 Downloads
Open Access
Observational Studies 13 Oct 2025
Safety Profile of COVID-19 Vaccines: Retrospective Analysis of Short, Medium, and Long-Term Side Effects: The Military Hospital Experience
Background: Vaccination is a key strategy to reduce infectious disease incidence and COVID-19 severity. Monitoring vaccine safety is essential to identify Adverse Reactions (ARs) and ensure public confidence.Objective: T…
2,194 Views 80 Downloads
Open Access
Review Article 08 Oct 2025
The Beneficial Role of Exercise and Whole-Food Plant-Based Diet in Coronary Artery Disease Prevention and Management
Coronary Artery Disease (CAD) remains a critical global health issue, substantially contributing to morbidity and mortality worldwide. The strategic combination of Regular Physical Exercise (RPE) and a Whole-Food Plant-B…
1,686 Views 91 Downloads
Open Access
Research Article 30 Sep 2025
Knowledge Attitude and Practice to awards Food Drug Interaction among Health Care Providers at Public Primary Hospitals of Southern Ethiopia
Background: Interactions between food and medications can greatly impact patient adherence and the overall effectiveness of drug therapy. In healthcare settings, Food-Drug Interactions (FDIs) are an increasing concern. V…
153 Views 88 Downloads
Open Access
Mini Review 04 Sep 2025
Bioactive Compounds in Anti-Inflammatory Prevention
Spices and flavorings have been used as food since ancient times and also as medicines and food preservatives in recent decades. Many spices-such as clove, oregano, thyme, cinnamon, and cumin-have been used to treat infe…
660 Views 77 Downloads
Open Access
Clinical Trials 30 Aug 2025
Tocilizumab Therapy in Giant Cell Arteritis: Insights from Clinical Experience
195 Views 67 Downloads
Open Access
Research Article 27 Aug 2025
NUVATUL-MZ Ointment for the Treatment of Ganglion Cyst
The most frequent soft tissue masses in the hand and wrist are ganglion cysts, which are the reason for a large portion of orthopaedic and hand surgery clinic appointments. Although these cysts are usually benign, they c…
206 Views 92 Downloads
Open Access
Perspective 11 Aug 2025
Harnessing Nutrition to Prevent Coronary Recoil in Drug-Coated Balloon Angioplasty: Insights from Bethsaida Hospital
The success of Drug-Coated Balloon (DCB) angioplasty hinges critically on effectively preventing coronary artery recoil, an acute elastic response that threatens procedural efficacy and long-term vessel patency. While te…
528 Views 79 Downloads
Open Access
Review Article 31 Jul 2025
Role of Cyclooxygenase-2 Inhibitors in Animal Models of Epilepsy: A Systematic Review
Background: The presence of recurrent seizures characterizes epilepsy, which is defined as a chronic disorder of the nervous system. It has recently been suggested that COX-2 inhibitors may offer protective neurotherapeu…
514 Views 105 Downloads
Open Access
Original Article 28 Jul 2025
Molecular Investigation of Cytochrome P-450 Enzymes Inductors
Cytochrome P-450 enzymes play a critical role in xenobiotic metabolism and homeostasis, with their induction offering therapeutic potential for liver diseases and metabolic disorders. Using molecular docking and statisti…
240 Views 81 Downloads
Open Access
Clinical Study 27 Jul 2025
A Clinical Study to Assess the Safety and Pharmacokinetics of Orally Administered Strontium L-lactate in Healthy Adults
Purpose: Strontium salts may provide support for bone health and treatment for osteoporosis, but the safety and effectiveness of these salts is not completely understood. The aim of this clinical study (NCT03761979) was …
373 Views 70 Downloads
Open Access
Case Report 16 Jul 2025
Case Presentation Corticosteroids as the treatment of Left Hypoglossal Nerve Paralysis in a 35-Year-Old Man Following a Jiu Jitsu Training Maneuver
This case report describes a rare instance of isolated left hypoglossal nerve (cranial nerve XII) paralysis in a 35-year-old male following a jiu jitsu training session. The patient presented with acute-onset dysarthria …
697 Views 75 Downloads
Open Access
Original Article 09 Jul 2025
Evaluation of the Effect of Ligaria cuneifolia Infusion on Plasma Cholesterol and Liver and Kidney Function in Patients with Cardiovascular Risk
Ligaria cuneifolia (R. et P.) Tiegh. –Loranthaceae– (Lc), commonly used in traditional medicine, is believed to reduce total plasma cholesterol (TC) and improve blood flow. Objective: To evaluate the effect of inges…
7 Views 83 Downloads
Open Access
Opinion 09 Jul 2025
Cracks in the Evidence: Why Studies from COURAGE to ISCHEMIA Failed to Show Benefit of Stenting PCI
Percutaneous Coronary Intervention (PCI) with stenting remains widely utilized for managing Chronic Coronary Syndrome (CCS). However, landmark clinical trials such as COURAGE and ISCHEMIA have repeatedly shown no signifi…
616 Views 74 Downloads
Open Access
Original Article 30 Jun 2025
The Abiwaijiwuli-Mufasili Attenuates Cartilage Damage and Ameliorates Osteoarthritis In vivo and In vitro By Regulating Serpina3-Mediated Wnt/b-Catenin Pathway
Introduction: Aibiwajiwuli-Mufasili (ABYJ), an ancient classic formula of Uyghur medicine, is used to treat osteoarthritis (OA) in clinical practice in China, yet the underlying mechanism remains obscure. We aimed to pro…
296 Views 86 Downloads
Open Access
Perspective 30 Jun 2025
Trans - Resveratrol as a Food Ingredient Safety Assessment
Resveratrol is a polyphenolic compound naturally found in various plants, notably in red grapes, and initially isolated from the roots of white hellebore. Due to its potential health-promoting properties, it has gained i…
3,546 Views 87 Downloads
Open Access
Perspective 30 Jun 2025
Transforming Cardiac Care through Plant-Based Diets: A Breakthrough Experience from Bethsaida Hospital, Indonesia
Seven years ago, at Bethsaida Hospital in Indonesia, Professor Dasaad Mulijono pioneered the integration of a Plant-Based Diet (PBD) into routine cardiac caresa paradigm shift that has dramatically improved outcomes for …
582 Views 85 Downloads
Open Access
Clinical Trials 14 Jun 2025
Gut Microbiota, Cardiovascular Innovation, and Lifestyle Medicine: Southeast Asia’s First Clinical Integration of TMAO Testing
Trimethylamine N-Oxide (TMAO) has emerged as a novel biomarker implicated in the pathogenesis and progression of various cardiometabolic conditions, including Coronary Artery Disease (CAD), stroke, type 2 diabetes mellit…
662 Views 80 Downloads
Open Access
Review Article 17 May 2025
The Role of Translation Initiation Regulation in Tumorigenesis, Progression and Drug Resistance
The initiation of mRNA translation plays a pivotal role in gene expression and has profound implications for tumorigenesis, tumor progression, and drug resistance. eIF4F complex, as an important part of the classical tra…
2,091 Views 87 Downloads
Open Access
Short Communication 12 May 2025
Autologous Angiogenic Cell Precursors- A Molecular Strategy for The Treatment of Heart Failure: Response to Biocardia’s Cardiamp HF Trial
507 Views 87 Downloads 1 Citation
Open Access
Review Article 24 Apr 2025
Healing with Food or Managing with Injection? A New Era in Chronic Disease Care
The global burden of chronic diseases, particularly obesity, diabetes, and cardiovascular diseases, continues to rise. While pharmacological interventions, such as Semaglutide, provide short-term benefits in weight manag…
483 Views 102 Downloads 1 Citation
Open Access
Review Article 28 Feb 2025
Mushrooms Natural Products Cosmetic Weapons as Anti-Hair Loss, Anti-Ageing Skin and Future Prospect
Throughout old history, mushrooms are considered a rich source of many important phytonutrients such as polysaccharides and other nutrients, in addition to many essential amino acids, which are building blocks of vital p…
8,958 Views 94 Downloads 1 Citation
Open Access
Short Communication 30 Nov 2024
Platelet Aggregation Modulation by a Cholesterol Derivative identified in Skin Secretions from Arabian Gulf Catfish (Arius bilineatus, Val.)
We present in this study that one Oxysterol (OS) within the lipid fraction of the isolated epidermal gel released from freshly caught catfish from the Arabian Gulf (Arius bilineatus, Val.) potently and selectively inhibi…
283 Views 111 Downloads
Open Access
Descriptive Research 10 Nov 2024
Pharmacological Evaluation of Atranorin: A Comprehensive Study on its Biological Activities
Lichens are a rich source of diverse secondary metabolites, with depsides playing a crucial role in their biological properties. Atranorin, a prominent depside, has been widely studied due to its significant pharmacologi…
933 Views 118 Downloads 2 Citations
Open Access
Original Article 25 Oct 2024
Comparative Analysis of Red and White Honeys Antimicrobial Activity against Specific Bacterial and Fungal Strains
Honeys popularity as a treatment is growing by the day, with many societies emphasizing its importance and its role in infections causing burns and wounds and recently gets focus from the medical community; as antimicrob…
506 Views 108 Downloads
Open Access
Clinical Trials 20 Sep 2024
Reviewing Clinical Trials and Meta-Analyses to Assess the Efficacy and Safety of Huachansu in Cancer Treatment
Traditional Chinese Medicine (TCM), including herbal remedies and animal secretions like HuaChansu, also called Cinobufacini, has gained attention for its therapeutic efficacy in cancer treatment. HuaChansu, extracted fr…
541 Views 100 Downloads 1 Citation
Open Access
Research Article 20 Sep 2024
Exploring the Potential of Xanthatin from Cuban Xanthium strumarium: Isolation, Characterization, and Biological Evaluation
Xanthatin possesses anticancer activities through its effect on cancer cell proliferation, apoptosis and metastasis In vitro and In vivo. Here, we described the isolation procedure, characterization and In vitro biologic…
342 Views 111 Downloads 2 Citations
Open Access
Short Communication 11 Sep 2024
Prophylaxis by Administration of Stable Iodine: Principle, Evolution and Recommendations
Prophylaxis by stable iodine “KI 65 mg, breakable tablet†is a pharmacological countermeasure of radiological protection adapted for the prevention of thyroid cancer after exposure to radioactive iodine. A first modi…
976 Views 91 Downloads
Open Access
Review Article 10 Aug 2024
Plants from South America: A Systematic Review of Their Antiplasmodial and Antimalarial Activities Based on Ethnopharmacological Use
Malaria remains one of the most important diseases in the world, being lethal to 610 thousand individuals annually. The widespread resistance of P. falciparum to antimalarials emphasizes the urgent need for new therapies…
342 Views 63 Downloads 2 Citations
Open Access
Research Article 05 Aug 2024
Mechanistic Insights into the Anti-Osteoporotic Effects of Naringin via Network Pharmacology and Molecular Docking Studies
Background: Naringin, a natural flavonoid prevalent in citrus fruits, is known for its antioxidant, anti-inflammatory, and antitumor properties. Recent studies suggest its potential influence on bone metabolism, proposin…
555 Views 64 Downloads 1 Citation
Open Access
Clinical Trials 08 Jul 2024
Effect of Hyperthermic Intraperitoneal Chemotherapy on Long Term Survival in Gastric Cancer with Peritoneal Metastasis Treated With Preoperative Intraperttoneal Chemotherapy plus Peritonectomy: The Phase III PM-GC-1 Trial
The presentation aims to describe the theory for Comprehensive Treatment (COMPT) in order to achieve cure of Colorectal Cancer (CRC)-patients with Peritoneal Metastasis (PM). Comprehensive Treatment (COMPT) consists of c…
1,585 Views 106 Downloads
Open Access
Clinical Trials 06 Jul 2024
Message Factors Affecting the Recruitment of Black Caribbean and African American Participants for Clinical Trials
The need for effective and ethical recruitment of Black Caribbean and African American individuals for participation in research studies and clinical trials is urgent; without adequate representation, findings cannot be …
560 Views 71 Downloads
Open Access
Research Article 14 Jun 2024
Experience on Utilization of Novel Modeling & Simulation Approaches in Generic Product Development
Modeling and simulation approaches such as Physiologically Based Pharmacokinetic (PBPK) and Physiologically Based Biopharmaceutics Modeling (PBBM) are gaining importance due to their impact to transform drug development …
776 Views 99 Downloads 4 Citations
Open Access
Research Article 22 May 2024
Punica granatum Bioactive Compounds-Loaded Chitosan Nanoparticles Exhibit Potent Antihyperglycemic Effect in Alloxan-Induced Diabetic Mice
In the current study, alloxan-induced diabetic mice model was used to assess the antihyperglycemic effects of Chitosan Nanoparticles (CSNP) loaded with (Punica granatum methanol extract-PG) bioactive compounds. Analysis …
427 Views 110 Downloads 1 Citation
Open Access
Review Article 30 Apr 2024
Most Chronic Medical Conditions in Women are related to Increased Cellular Permeability and most can be Effectively Treated with Dopaminergic Drugs
Based on a conglomeration of basic science research studies a model of hypothetical mechanisms of how the fetal semi-allograft can develop into a live baby was created. One of the tenets of the model is that it is necess…
627 Views 109 Downloads 2 Citations
Open Access
Research Article 29 Feb 2024
Antibacterial Effect of Indian Gooseberry (Phyllanthus emblica L.) Extract Against ESBL Producing Multi-Drug Resistant Bacteria
The most celebrating fruit in Indian traditional medicine Ayurveda is the Indian gooseberry also known as amla fruit, used the prevention of numerous diseases. No reports are available on the prevention of ESBL produced …
5,362 Views 130 Downloads 3 Citations
Open Access
Review Article 15 Feb 2024
Drug Design Strategies, Modes of Action, Synthesis and Industrial Challenges Behind Trifluoromethylated New Chemical Entities
Medicinal plants have been an inspiration source for developing new chemical entities, providing diverse chemical structures and modes of action for medicinal chemistry strategies. Modern medicinal chemistry approaches p…
30,323 Views 120 Downloads 5 Citations
Open Access
Editorial 08 Feb 2024
Tapering as a Progressive Strategy: The Need for Policy Changes to Fund a Promising Addiction Treatment
With the recent rise of drug use such as heroin, benzodiapenes, and xylazine, substance misuse has increasingly affected millions of individuals across the globe. The opioid crisis in particular is a major concern that p…
1,356 Views 123 Downloads
Open Access
Clinical Trials 02 Feb 2024
Angiogenic Precursor Cell Treatment of Critical Limb Ischemia Decreases Ulcer Size, Amputation and Death Rate: Re-Examination of phase II ACP NO-CLI Trial Data
Introduction: Critical limb ischemia has a prevalence in the US of 1.33%, with mortality 15-20% and major amputation 10-40% per year. Stem cell treatment has emerged as a treatment option for the 45% of patients for who…
1,668 Views 149 Downloads 1 Citation
Open Access
Brief Communication 15 Jan 2024
Auctox A New Method to Evaluate the Safety of Anticancer Drugs
The evaluation of anticancer drugs safety is currently based on considering the worst Adverse Event (AE) in a particular patient. The aim of the study was to define a new method which would better describe the impact of …
643 Views 116 Downloads
Open Access
Research Article 17 Nov 2023
Network Pharmacology Study of Huangqi-Huangjing in the Treatment of Diabetic Nephropathy and Diabetic Cardiomyopathy
Objective: To systematically investigate the mechanism of Huangqi-Huangjing in the treatment of Diabetic Nephropathy (DN) and Diabetic Cardiomyopathy (DC) using network pharmacology and molecular docking analysis. To pro…
1,204 Views 121 Downloads
Open Access
Research Article 10 Aug 2023
Ultrasonic-Assisted Extraction of Bioactive Compounds from Elecampagne (Inula helenium, Radix Inulae)
In this study, we had developed a method of ultrasound assisted extraction from Elecampane in order to obtain, identify and the dosing the main bioactive compounds from plant, such as: alantolactone and isoalantolactone,…
1,976 Views 102 Downloads 1 Citation