The most frequent soft tissue masses in the hand and wrist are ganglion cysts, which are the reason for a large portion of orthopaedic and hand surgery clinic appointments. Although these cysts are usually benign, they can limit function, cause pain, and raise aesthetic problems. The epidemiology, pathogenesis, histological characteristics, clinical presentation, diagnostic methods, available treatments, and current research advancements are all thoroughly researched in this article. It also covers Formulation & Evaluation of NUVATUL-MZ ointment for ganglion cyst.