Coronary Artery Disease (CAD) remains a critical global health issue, substantially contributing to morbidity and mortality worldwide. The strategic combination of Regular Physical Exercise (RPE) and a Whole-Food Plant-Based Diet (WFPBD) offers an innovative and powerful solution to mitigate cardiovascular disease risk. Under the visionary leadership of Prof. Dasaad Mulijono, Bethsaida Hospital in Tangerang has successfully pioneered this integrative approach, achieving exceptional clinical results. This comprehensive review examines the multifaceted cardiovascular benefits of RPE and plant-based nutritional therapy, highlighting improvements in lipid profiles, insulin sensitivity, blood pressure regulation, cardiac and vascular remodelling, sleep quality, mitochondrial function, and cellular longevity. Highlighting the ground-breaking clinical outcomes at Bethsaida Cardiac Centre, this integrative model addresses traditional cardiovascular risk factors, enhances overall vitality, and promotes longevity, representing a transformative framework for modern cardiovascular healthcare.