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Home/ All Articles/ Platelet Aggregation Modulation by a Cholesterol Derivative identified in Skin Secretions …

Abstract & Article Details

Short Communication • Vol.5, Issue 11 • ISSN: 2766-2276 • Open Access • CC BY 4.0

Open Access Short Communication Vol.5, Issue 11 November 30, 2024

Platelet Aggregation Modulation by a Cholesterol Derivative identified in Skin Secretions from Arabian Gulf Catfish (Arius bilineatus, Val.)

DOI: 10.37871/jbres2041
Authors
Jassim M Al-Hassan, Mohammad Afzal, Sosamma Oommen, Yuan Fang Liu, Meraj Khan and Cecil Pace-Asciak*
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Abstract

We present in this study that one Oxysterol (OS) within the lipid fraction of the isolated epidermal gel released from freshly caught catfish from the Arabian Gulf (Arius bilineatus, Val.) potently and selectively inhibits the collagen-evoked aggregation of human platelets in vitro. This cholesterol metabolite, identified as Cholesterol-3,5,6-triol (S5) is one of 14 steroids/oxysterols identified in the lipid fraction of the secreted epidermal gel. The selective ­­action of S5 in this study suggests that it may have efficacy in cancer therapy as platelet inhibition has been shown to be important in the therapeutic control of cancer and in other chronic diseases including inflammation and related diseases.

FullText HTML FullText PDF DOI: 10.37871/jbres2041 CrossMark

Research Topics

Pharmacology

How to Cite

Jassim M Al-Hassan, Mohammad Afzal, Sosamma Oommen, Yuan Fang Liu, Meraj Khan and Cecil Pace-Asciak* (2024). Platelet Aggregation Modulation by a Cholesterol Derivative identified in Skin Secretions from Arabian Gulf Catfish (Arius bilineatus, Val.). Journal of Biomedical Research & Environmental Sciences, 5(11). https://doi.org/10.37871/jbres2041

Article Information

JournalJournal of Biomedical Research & Environmental Sciences (JBRES)
ISSN2766-2276
DOI DOI 10.37871/jbres2041
Volume / IssueVol. 5, Issue 11
PublishedNovember 30, 2024
Article TypeShort Communication
Pages1525-1530
LicenseCC BY 4.0 — Open Access
PublisherSciRes Literature LLC, Sheridan, WY, USA
LanguageEnglish
Creative Commons BY 4.0

Published under CC BY 4.0 — free to share, copy, adapt, and redistribute with attribution.

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