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Quercetin Analogs as Cancer Chemopreventive Agents: A New Perspective

Journal of Biomedical Research & Environmental Sciences article abstract with citation details, DOI, publication dates, subject areas, full text links, and references.

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Open Access
Article Type Perspective
Subject Medicine Group
OCLC JBRES Record
Aliabadi A, Mahboubi RM, Bayat L, Hakimimofrad R, Ghobadi K, Omidifard N, Chaman A, Bayanati M and Zarghi A*
Issue: Volume6-Issue10
Pages: 1514-1539
Received: 2025-09-28
Accepted: 2025-10-22
Published: 2025-10-23

Abstract

Quercetin is a flavonoid-type chemical molecule found in many people's daily diets. Previous research has shown that quercetin offers a range of benefits, including anti-inflammatory, antioxidant, and cancer-prevention properties. A combination of In vivo and In vitro studies showed that quercetin may have anti-tumor actions via modifying the advancement of the cell cycle, reducing cell division, inducing apoptosis, limiting revascularization and metastatic progression, and influencing autophagy. On the other hand, quercetin's strong toxic action on cancer cells is accompanied by little or no adverse reactions or injury to healthy cells. The previously published data showed that quercetin may act as a potent inhibitor of Cyclooxygenase 2 (COX-2). Quercetin was also found to be useful in preventing neurological illnesses like Alzheimer's and Parkinson's disease, as well as cardiac and chronic inflammatory diseases, including rheumatoid arthritis and rheumatic heart failure. The present review article highlights the data regarding quercetin's pharmacodynamic capability for cancer inhibition as a potent inhibitor for COX-2, supporting the idea that quercetin should be seriously evaluated as a treatment against a variety of cancer types. A basic docking investigation was also added, demonstrating that this chemical interacts effectively with the COX-2. The findings supported the outcome of previous investigations on quercetin's inhibitory effects on the enzyme. Other modes of action for this chemical were also briefly discussed, including inhibition of mTOR, Akt, PARP, and PI3K signaling pathways.

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© 2025 Zarghi A, et al. Distributed under Creative Commons CC-BY 4.0 Creative CommonsAttribution

How to cite this article

Aliabadi A, Mahboubi RM, Bayat L, Hakimimofrad R, Ghobadi K, Omidifard N, Chaman A, Bayanati M, Zarghi A. Quercetin Analogs as Cancer Chemopreventive Agents: A New Perspective. J Biomed Res Environ Sci. 2025 Oct 23; 6(10): 1514-1539. doi: 10.37871/jbres2207, Article ID: JBRES2207, Available at: https:// www.jelsciences.com/articles/jbres2207.pdf

Subject area(s)

OncologyTherapeuticsPharmacology

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