Weiwei Qi, Junjie Guo and XueXu*
Volume6-Issue7
Dates: Received: 2025-06-25 | Accepted: 2025-07-01 | Published: 2025-07-02
Pages: 858-861
Abstract
Entamoeba dispar, belonging to the Genus Entamoeba along with Entamoeba histolytica that causes amebiasis, was previously considered a non-pathogenic ameba and an ideal model for studying the pathogenesis of amebiasis. However, since its strains were isolated from symptomatic patients in Brazil in 1996, its pathogenic potential has been a subject of discussion. We report a case of multiple granulomatous encephalitis in a 4-year-old immunocompetent boy presenting with left eye esotropia. Sequences of E. dispar were detected in his cerebrospinal fluid through Next-Generation Sequencing (NGS). After three courses of metronidazole therapy, the brain and lung lesions showed significant reduction in subsequent examinations. This case expands the spectrum of diseases associated with E. dispar.
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DOI: 10.37871/jbres2138
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© 2025 Santos Federico OR, et al., Distributed under Creative Commons CC-BY 4.0 
How to cite this article
Qi W, Guo J, Xu X. Granulomatous Amebic Encephalitis Caused by Entamoeba Dispar. J Biomed Res Environ Sci. 2025 Jul 01; 6(7): 858-861. doi: 10.37871/jbres2138, Article ID: JBRES2138, Available at: https://www.jelsciences. com/articles/jbres2138.pdf
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References
- de Martinez AM, Gomes MA, Viana Jda C, Romanha AJ, Silva EF. Isoenzyme profile as parameter to differentiate pathogenic strains of Entamoeba histolytica in Brazil. Rev Inst Med Trop Sao Paulo. 1996 Nov-Dec;38(6):407-12. doi: 10.1590/s0036-46651996000600004. PMID: 9293086.
- Ximénez C, Cerritos R, Rojas L, Dolabella S, Morán P, Shibayama M, González E, Valadez A, Hernández E, Valenzuela O, Limón A, Partida O, Silva EF. Human amebiasis: breaking the paradigm? Int J Environ Res Public Health. 2010 Mar;7(3):1105-20. doi: 10.3390/ijerph7031105. Epub 2010 Mar 16. PMID: 20617021; PMCID: PMC2872301.
- Pana A, Vijayan V, Anilkumar AC. Amebic Meningoencephalitis. 2023 Jan 21. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 28613505.
- Kalra SK, Sharma P, Shyam K, Tejan N, Ghoshal U. Acanthamoeba and its pathogenic role in granulomatous amebic encephalitis. Exp Parasitol. 2020 Jan;208:107788. doi: 10.1016/j.exppara.2019.107788. Epub 2019 Oct 21. PMID: 31647916.