Covid-19 Research

Mini Review

Advances in Personalized Medicine Personalized Neoantigen Vaccines and Immune Checkpoint Inhibitor Combination Treatments

Journal of Biomedical Research & Environmental Sciences article abstract with citation details, DOI, publication dates, subject areas, full text links, and references.

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Open Access
Article Type Mini Review
Subject Biology Group
OCLC JBRES Record
Priya Hays*
Issue: Volume6-Issue2
Pages: 172-179
Received: 2025-02-15
Accepted: 2025-02-27
Published: 2025-02-28

Abstract

Background: Solid tumor malignancies are a cause of mortality in adults, with growing prevalence in young adults. Chemotherapies in combination with immune checkpoint inhibitors have been shown to induce responses in these tumors through T cell responses, however non-responders in the clinical setting have been observed.

Methods: PubMed searches were conducted with the keywords “Cancer vaccines”, “Personalized vaccines,” “tumor neoantigens” and “cancer immunotherapies.”

Results: Personalized neoantigen vaccines constructed from primarily DNA, RNA and peptides have been shown to generate CD4+ and CD8+ T cell responses, resulting in delay in tumor growth and tumor regression. Created from tumor specific antigens, they are unique to each patient. Experiments detecting for T cell responses and preclinical models have provided evidence for the safety, feasibility and clinical efficacy of personalized neoantigen vaccines and immune checkpoint inhibitor combination treatments.

Conclusion: Future research can be directed to developing personalized neoantigen vaccines-ICI combination treatments for treatment of cancer and hematologic malignancies.

FullText HTML FullText PDF DOI: 10.37871/jbres2069 Crossmark

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© 2025 Hays P. Distributed under Creative Commons CC-BY 4.0 Creative CommonsAttribution

How to cite this article

Hays P. Advances in Personalized Medicine: Personalized Neoantigen Vaccines and Immune Checkpoint Inhibitor Combination Treatments. J Biomed Res Environ Sci. 2025 Feb 28; 6(2): 172-179. doi: 10.37871/ jbres2069, Article ID: JBRES2069, Available at: https://www.jelsciences.com/articles/jbres2069.pdf

Subject area(s)

Vaccines

References

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