Maamar Souidi*, Marc Benderitter and Francois Caire-Maurisier
Volume5-Issue9
Dates: Received: 2024-09-03 | Accepted: 2024-09-08 | Published: 2024-09-11
Pages: 1109-1110
Abstract
Prophylaxis by stable iodine “KI 65 mg, breakable tablet” is a pharmacological countermeasure of radiological protection adapted for the prevention of thyroid cancer after exposure to radioactive iodine. A first modification of the marketing authorization of “KI 65 mg, breakable tablet” for repeated prophylaxis for adults and children above 12 years old was obtained in France in 2020. At this point in time, the recommendation of a unique “KI” intake by pregnant and breastfeeding women and children below 12 years old remain valid.
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DOI: 10.37871/jbres1996
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© 2024 Souidi M, et al. Distributed under Creative Commons CC-BY 4.0
How to cite this article
Souidi M, Benderitter M, Caire-Maurisier F. Prophylaxis by Administration of Stable Iodine: Principle, Evolution and Recommendations. J Biomed Res Environ Sci. 2024 Sept 11; 5(9): 1109-1110. doi: 10.37871/jbres1996, Article ID: JBRES1996, Available at: https://www.jelsciences.com/articles/jbres1996.pdf
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References
- IAEA. International Atomic Energy Agency, Frequently asked Chernobyl questions. 2016.
- UNSCEAR. United Nations Scientific Committee on the Effects of Atomic Radiation 2020/2021 Report to the General Assembly with Scientific Annexes Volume I, II, Scientific Annex B sources, effects and risks of ionizing radiation.
- Ron E. Thyroid cancer incidence among people living in areas contaminated by radiation from the Chernobyl accident. Health Phys. 2007 Nov;93(5):502-11. doi: 10.1097/01.HP.0000279018.93081.29. PMID: 18049226.
- UNSCEAR. Evaluation of data on thyroid cancer in regions affected by the Chernobyl accident: a white paper to guide the Scientific Committee’s future pro gramme of work. In: Sources and effects of ionizing radiation. United Nations Scientific Committee on the Effects of Atomic Radiation. 2018.
- UNSCEAR. sources and effects of ionizing radiation, United Nations Scientific Committee on the Effects of Atomic Radiation, Report to the General Assembly with Scientific Annexes Volume II, Scientific Annexes C, D and E. 2008.
- Nauman J, Wolff J. Iodide prophylaxis in Poland after the Chernobyl reactor accident: benefits and risks. Am J Med. 1993 May;94(5):524-532. doi: 10.1016/0002-9343(93)90089-8. PMID: 8498398.
- Carvalho DP, Dupuy C. Thyroid hormone biosynthesis and release. Mol Cell Endocrinol. 2017 Dec 15;458:6-15. doi: 10.1016/j.mce.2017.01.038. Epub 2017 Jan 31. PMID: 28153798.
- Zanzonico PB, Becker DV. Effects of time of administration and dietary iodine levels on potassium iodide (KI) blockade of thyroid irradiation by 131I from radioactive fallout. Health Phys. 2000 Jun;78(6):660-7. doi: 10.1097/00004032-200006000-00008. PMID: 10832925.
- Iodine Thyroid Blocking: Guidelines for Use in Planning for and Responding to Radiological and Nuclear Emergencies. Geneva: World Health Organization; 2017. PMID: 29630192.
- WOLFF J, CHAIKOFF IL. Plasma inorganic iodide as a homeostatic regulator of thyroid function. J Biol Chem. 1948 Jun;174(2):555-64. PMID: 18865621.
- Iervasi G, Nicolini G. Thyroid hormone and cardiovascular system: from basic concepts to clinical application. Intern Emerg Med. 2013 Apr;8 Suppl 1:S71-4. doi: 10.1007/s11739-013-0911-4. PMID: 23435988.
- Toft DJ, Schneider AB. Protecting the Thyroid in Times of Conflict (Ukraine 2022). Thyroid. 2022 Jun;32(6):607-610. doi: 10.1089/thy.2022.0135. Epub 2022 May 23. PMID: 35469429.
- Martin JC, Pourcher T, Phan G, Guglielmi J, Crambes C, Caire-Maurisier F, Lebsir D, Cohen D, Rosique C, Jing L, Hichri M, Salleron L, Darcourt J, Souidi M, Benderitter M. Review of the PRIODAC project on thyroid protection from radioactive iodine by repeated iodine intake in individuals aged 12. Eur Thyroid J. 2024 Jan 1;13(1):e230139. doi: 10.1530/ETJ-23-0139. Epub ahead of print. PMID: 38241789; PMCID: PMC10895330.