Covid-19 Research

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Inflammation as the Common Pathophysiology Linking Stress, Mental Illness, Autoimmunity and Chronic Disease: Implications for Public Health Policy

Medicine Group    Start Submission

Daniel A Kinderlehrer*

Volume5-Issue3
Dates: Received: 2024-03-16 | Accepted: 2024-03-26 | Published: 2024-03-28
Pages: 242-255

Abstract

Genetics, epigenetics, infection, stress and trauma predispose individuals to systemic chronic inflammation that contributes to mental illness, autoimmune conditions, and chronic disease. This paper explores the interplay of these issues and their serious health consequences. While modern medicine has made significant advances in disease care, it appears that lifestyle intervention, early childhood intervention, and socioeconomic investment and have the potential to make an even greater impact on the mental and physical well-being of the population.

FullText HTML FullText PDF DOI: 10.37871/jbres1889


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© 2024 Kinderlehrer DA. Distributed under Creative Commons CC-BY 4.0

How to cite this article

Kinderlehrer DA. Infl ammation as the Common Pathophysiology Linking Stress, Mental Illness, Autoimmunity and Chronic Disease: Implications for Public Health Policy. J Biomed Res Environ Sci. 2024 Mar 28; 5(3): 242-255. doi: 10.37871/jbres1889, Article ID: JBRES1889, Available at: https://www.jelsciences.com/articles/jbres1889.pdf


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References


  1. Ader R, Cohen N. Behaviorally conditioned immunosuppression. Psychosom Med. 1975 Jul-Aug;37(4):333-40. doi: 10.1097/00006842-197507000-00007. PMID: 1162023.
  2. Thibaut F. The mind-body Cartesian dualism and psychiatry. Dialogues Clin Neurosci. 2018 Mar;20(1):3. doi: 10.31887/DCNS.2018.20.1/fthibaut. PMID: 29946205; PMCID: PMC6016047.
  3. Koelsch S, Boehlig A, Hohenadel M, Nitsche I, Bauer K, Sack U. The impact of acute stress on hormones and cytokines, and how their recovery is affected by music-evoked positive mood. Sci Rep. 2016 Mar 29;6:23008. doi: 10.1038/srep23008. PMID: 27020850; PMCID: PMC4810374.
  4. La Cava A. Leptin in inflammation and autoimmunity. Cytokine. 2017 Oct;98:51-58. doi: 10.1016/j.cyto.2016.10.011. PMID: 27916613; PMCID: PMC5453851.
  5. Pittman QJ. A neuro-endocrine-immune symphony. J Neuroendocrinol. 2011 Dec;23(12):1296-7. doi: 10.1111/j.1365-2826.2011.02176.x. PMID: 22092721.
  6. França K, Lotti TM. Psycho-Neuro-Endocrine-Immunology: A Psychobiological Concept. Adv Exp Med Biol. 2017;996:123-134. doi: 10.1007/978-3-319-56017-5_11. PMID: 29124696.
  7. Liu YZ, Wang YX, Jiang CL. Inflammation: The Common Pathway of Stress-Related Diseases. Front Hum Neurosci. 2017 Jun 20;11:316. doi: 10.3389/fnhum.2017.00316. PMID: 28676747; PMCID: PMC5476783.
  8. Guidi J, Lucente M, Sonino N, Fava GA. Allostatic Load and Its Impact on Health: A Systematic Review. Psychother Psychosom. 2021;90(1):11-27. doi: 10.1159/000510696. Epub 2020 Aug 14. PMID: 32799204.
  9. Blackwell TS, Christman JW. The role of nuclear factor-kappa B in cytokine gene regulation. Am J Respir Cell Mol Biol. 1997 Jul;17(1):3-9. doi: 10.1165/ajrcmb.17.1.f132. PMID: 9224203.
  10. Feng T, Tripathi A, Pillai A. Inflammatory Pathways in Psychiatric Disorders: The case of Schizophrenia and Depression. Curr Behav Neurosci Rep. 2020 Sep;7(3):128-138. doi: 10.1007/s40473-020-00207-4. Epub 2020 Jul 26. PMID: 34178573; PMCID: PMC8223755.
  11. Maydych V. The Interplay Between Stress, Inflammation, and Emotional Attention: Relevance for Depression. Front Neurosci. 2019 Apr 24;13:384. doi: 10.3389/fnins.2019.00384. PMID: 31068783; PMCID: PMC6491771.
  12. Haroon E, Raison CL, Miller AH. Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior. Neuropsychopharmacology. 2012 Jan;37(1):137-62. doi: 10.1038/npp.2011.205. Epub 2011 Sep 14. PMID: 21918508; PMCID: PMC3238082.
  13. Gupta S, Guleria RS. Involvement of Nuclear Factor-κB in Inflammation and Neuronal Plasticity Associated with Post-Traumatic Stress Disorder. Cells. 2022 Jun 27;11(13):2034. doi: 10.3390/cells11132034. PMID: 35805118; PMCID: PMC9265339.
  14. Köhler CA, Freitas TH, Maes M, de Andrade NQ, Liu CS, Fernandes BS, Stubbs B, Solmi M, Veronese N, Herrmann N, Raison CL, Miller BJ, Lanctôt KL, Carvalho AF. Peripheral cytokine and chemokine alterations in depression: a meta-analysis of 82 studies. Acta Psychiatr Scand. 2017 May;135(5):373-387. doi: 10.1111/acps.12698. Epub 2017 Jan 25. PMID: 28122130.
  15. Won E, Kim YK. Neuroinflammation-Associated Alterations of the Brain as Potential Neural Biomarkers in Anxiety Disorders. Int J Mol Sci. 2020 Sep 7;21(18):6546. doi: 10.3390/ijms21186546. PMID: 32906843; PMCID: PMC7555994.
  16. Benedetti F, Aggio V, Pratesi ML, Greco G, Furlan R. Neuroinflammation in Bipolar Depression. Front Psychiatry. 2020 Feb 26;11:71. doi: 10.3389/fpsyt.2020.00071. PMID: 32174850; PMCID: PMC7054443.
  17. Kose M, Pariante CM, Dazzan P, Mondelli V. The Role of Peripheral Inflammation in Clinical Outcome and Brain Imaging Abnormalities in Psychosis: A Systematic Review. Front Psychiatry. 2021 Feb 19;12:612471. doi: 10.3389/fpsyt.2021.612471. PMID: 33679475; PMCID: PMC7933584.
  18. Orsolini L, Pompili S, Tempia Valenta S, Salvi V, Volpe U. C-Reactive Protein as a Biomarker for Major Depressive Disorder? Int J Mol Sci. 2022 Jan 30;23(3):1616. doi: 10.3390/ijms23031616. PMID: 35163538; PMCID: PMC8836046.
  19. Fitton R, Sweetman J, Heseltine-Carp W, van der Feltz-Cornelis C. Anti-inflammatory medications for the treatment of mental disorders: A scoping review. Brain Behav Immun Health. 2022;26:100518. Published 2022 Sep 19. doi:10.1016/j.bbih.2022.100518.
  20. Ravan JR, Chatterjee S, Singh P, Maikap D, Padhan P. Autoimmune Rheumatic Diseases Masquerading as Psychiatric Disorders: A Case Series. Mediterr J Rheumatol. 2021 Jun 30;32(2):164-167. doi: 10.31138/mjr.32.2.164. PMID: 34447914; PMCID: PMC8369283.
  21. Chang K, Frankovich J, Cooperstock M, Cunningham MW, Latimer ME, Murphy TK, Pasternack M, Thienemann M, Williams K, Walter J, Swedo SE; PANS Collaborative Consortium. Clinical evaluation of youth with pediatric acute-onset neuropsychiatric syndrome (PANS): recommendations from the 2013 PANS Consensus Conference. J Child Adolesc Psychopharmacol. 2015 Feb;25(1):3-13. doi: 10.1089/cap.2014.0084. Epub 2014 Oct 17. PMID: 25325534; PMCID: PMC4340805.
  22. Breithaupt L, Köhler-Forsberg O, Larsen JT, Benros ME, Thornton LM, Bulik CM, Petersen L. Association of Exposure to Infections in Childhood With Risk of Eating Disorders in Adolescent Girls. JAMA Psychiatry. 2019 Aug 1;76(8):800-809. doi: 10.1001/jamapsychiatry.2019.0297. Erratum in: JAMA Psychiatry. 2019 May 8;: PMID: 31017632; PMCID: PMC6487907.
  23. Kinderlehrer DA. Anorexia Nervosa Caused by Polymicrobial Tick-Borne Infections: A Case Study. Int Med Case Rep J. 2021 May 10;14:279-287. doi: 10.2147/IMCRJ.S311516. PMID: 34007219; PMCID: PMC8121620.
  24. Köhler-Forsberg O, Petersen L, Gasse C, Mortensen PB, Dalsgaard S, Yolken RH, Mors O, Benros ME. A Nationwide Study in Denmark of the Association Between Treated Infections and the Subsequent Risk of Treated Mental Disorders in Children and Adolescents. JAMA Psychiatry. 2019 Mar 1;76(3):271-279. doi: 10.1001/jamapsychiatry.2018.3428. PMID: 30516814; PMCID: PMC6439826.
  25. Bransfield RC, Mao C, Greenberg R. Microbes and Mental Illness: Past, Present, and Future. Healthcare (Basel). 2023 Dec 29;12(1):83. doi: 10.3390/healthcare12010083. PMID: 38200989; PMCID: PMC10779437.
  26. Bransfield RC. The psychoimmunology of lyme/tick-borne diseases and its association with neuropsychiatric symptoms. Open Neurol J. 2012;6:88-93. doi: 10.2174/1874205X01206010088. Epub 2012 Oct 5. PMID: 23091569; PMCID: PMC3474947.
  27. Dalmau J, Armangué T, Planagumà J, Radosevic M, Mannara F, Leypoldt F, Geis C, Lancaster E, Titulaer MJ, Rosenfeld MR, Graus F. An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models. Lancet Neurol. 2019 Nov;18(11):1045-1057. doi: 10.1016/S1474-4422(19)30244-3. Epub 2019 Jul 17. PMID: 31326280.
  28. Sun Y, Qu Y, Zhu J. The Relationship Between Inflammation and Post-traumatic Stress Disorder. Front Psychiatry. 2021 Aug 11;12:707543. doi: 10.3389/fpsyt.2021.707543. PMID: 34456764; PMCID: PMC8385235.
  29. Sadeh N, Spielberg JM, Warren SL, Miller GA, Heller W. Aberrant Neural Connectivity during Emotional Processing Associated with Posttraumatic Stress. Clin Psychol Sci. 2014 Nov;2(6):748-755. doi: 10.1177/2167702614530113. PMID: 25419500; PMCID: PMC4238937.
  30. Sherin JE, Nemeroff CB. Post-traumatic stress disorder: the neurobiological impact of psychological trauma. Dialogues Clin Neurosci. 2011;13(3):263-78. doi: 10.31887/DCNS.2011.13.2/jsherin. PMID: 22034143; PMCID: PMC3182008.
  31. Lee DH, Lee JY, Hong DY, Lee EC, Park SW, Lee MR, Oh JS. Neuroinflammation in Post-Traumatic Stress Disorder. Biomedicines. 2022 Apr 20;10(5):953. doi: 10.3390/biomedicines10050953. PMID: 35625690; PMCID: PMC9138406.
  32. Eraly SA, Nievergelt CM, Maihofer AX, Barkauskas DA, Biswas N, Agorastos A, O'Connor DT, Baker DG; Marine Resiliency Study Team. Assessment of plasma C-reactive protein as a biomarker of posttraumatic stress disorder risk. JAMA Psychiatry. 2014 Apr;71(4):423-31. doi: 10.1001/jamapsychiatry.2013.4374. PMID: 24576974; PMCID: PMC4032578.
  33. Cohen M, Meir T, Klein E, Volpin G, Assaf M, Pollack S. Cytokine levels as potential biomarkers for predicting the development of posttraumatic stress symptoms in casualties of accidents. Int J Psychiatry Med. 2011;42(2):117-31. doi: 10.2190/PM.42.2.b. PMID: 22409092.
  34. Felitti VJ, Anda RF, Nordenberg D, Williamson DF, Spitz AM, Edwards V, Koss MP, Marks JS. Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. Am J Prev Med. 1998 May;14(4):245-58. doi: 10.1016/s0749-3797(98)00017-8. PMID: 9635069.
  35. Meeker EC, O'Connor BC, Kelly LM, Hodgeman DD, Scheel-Jones AH, Berbary C. The impact of adverse childhood experiences on adolescent health risk indicators in a community sample. Psychol Trauma. 2021 Mar;13(3):302-312. doi: 10.1037/tra0001004. Epub 2021 Feb 4. PMID: 33539157; PMCID: PMC8281335.
  36. Felitti VJ. Belastungen in der Kindheit und Gesundheit im Erwachsenenalter: die Verwandlung von Gold in Blei [The relationship of adverse childhood experiences to adult health: Turning gold into lead]. Z Psychosom Med Psychother. 2002;48(4):359-69. German. doi: 10.13109/zptm.2002.48.4.359. PMID: 12407494.
  37. Chu WW, Chu NF. Adverse childhood experiences and development of obesity and diabetes in adulthood-A mini review. Obes Res Clin Pract. 2021 Mar-Apr;15(2):101-105. doi: 10.1016/j.orcp.2020.12.010. Epub 2021 Jan 29. PMID: 33518485.
  38. Dong M, Giles WH, Felitti VJ, Dube SR, Williams JE, Chapman DP, Anda RF. Insights into causal pathways for ischemic heart disease: adverse childhood experiences study. Circulation. 2004 Sep 28;110(13):1761-6. doi: 10.1161/01.CIR.0000143074.54995.7F. Epub 2004 Sep 20. PMID: 15381652.
  39. Dube SR, Miller JW, Brown DW, Giles WH, Felitti VJ, Dong M, Anda RF. Adverse childhood experiences and the association with ever using alcohol and initiating alcohol use during adolescence. J Adolesc Health. 2006 Apr;38(4):444.e1-10. doi: 10.1016/j.jadohealth.2005.06.006. PMID: 16549308.
  40. Dong M, Dube SR, Felitti VJ, Giles WH, Anda RF. Adverse childhood experiences and self-reported liver disease: new insights into the causal pathway. Arch Intern Med. 2003 Sep 8;163(16):1949-56. doi: 10.1001/archinte.163.16.1949. PMID: 12963569.
  41. Brown DW, Anda RF, Tiemeier H, Felitti VJ, Edwards VJ, Croft JB, Giles WH. Adverse childhood experiences and the risk of premature mortality. Am J Prev Med. 2009 Nov;37(5):389-96. doi: 10.1016/j.amepre.2009.06.021. PMID: 19840693.
  42. Danese A, Pariante CM, Caspi A, Taylor A, Poulton R. Childhood maltreatment predicts adult inflammation in a life-course study. Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1319-24. doi: 10.1073/pnas.0610362104. Epub 2007 Jan 17. PMID: 17229839; PMCID: PMC1783123.
  43. Dube SR, Fairweather D, Pearson WS, Felitti VJ, Anda RF, Croft JB. Cumulative childhood stress and autoimmune diseases in adults. Psychosom Med. 2009 Feb;71(2):243-50. doi: 10.1097/PSY.0b013e3181907888. Epub 2009 Feb 2. PMID: 19188532; PMCID: PMC3318917.
  44. Shen CC, Yang AC, Kuo BI, Tsai SJ. Risk of Psychiatric Disorders Following Primary Sjögren Syndrome: A Nationwide Population-based Retrospective Cohort Study. J Rheumatol. 2015 Jul;42(7):1203-8. doi: 10.3899/jrheum.141361. Epub 2015 May 15. PMID: 25979721.
  45. Meszaros ZS, Perl A, Faraone SV. Psychiatric symptoms in systemic lupus erythematosus: a systematic review. J Clin Psychiatry. 2012 Jul;73(7):993-1001. doi: 10.4088/JCP.11r07425. Epub 2012 May 1. PMID: 22687742; PMCID: PMC9903299.
  46. Mura G, Bhat KM, Pisano A, Licci G, Carta M. Psychiatric symptoms and quality of life in systemic sclerosis. Clin Pract Epidemiol Ment Health. 2012;8:30-5. doi: 10.2174/1745017901208010030. Epub 2012 Apr 20. PMID: 22550545; PMCID: PMC3339425.
  47. Bernstein CN, Hitchon CA, Walld R, Bolton JM, Sareen J, Walker JR, Graff LA, Patten SB, Singer A, Lix LM, El-Gabalawy R, Katz A, Fisk JD, Marrie RA; CIHR Team in Defining the Burden and Managing the Effects of Psychiatric Comorbidity in Chronic Immunoinflammatory Disease. Increased Burden of Psychiatric Disorders in Inflammatory Bowel Disease. Inflamm Bowel Dis. 2019 Jan 10;25(2):360-368. doi: 10.1093/ibd/izy235. PMID: 29986021; PMCID: PMC6391845.
  48. Lwin MN, Serhal L, Holroyd C, Edwards CJ. Rheumatoid Arthritis: The Impact of Mental Health on Disease: A Narrative Review. Rheumatol Ther. 2020 Sep;7(3):457-471. doi: 10.1007/s40744-020-00217-4. Epub 2020 Jun 13. PMID: 32535834; PMCID: PMC7410879.
  49. Silveira C, Guedes R, Maia D, Curral R, Coelho R. Neuropsychiatric Symptoms of Multiple Sclerosis: State of the Art. Psychiatry Investig. 2019 Dec;16(12):877-888. doi: 10.30773/pi.2019.0106. Epub 2019 Dec 9. PMID: 31805761; PMCID: PMC6933139.
  50. Fukao A, Takamatsu J, Arishima T, Tanaka M, Kawai T, Okamoto Y, Miyauchi A, Imagawa A. Graves' disease and mental disorders. J Clin Transl Endocrinol. 2019 Oct 11;19:100207. doi: 10.1016/j.jcte.2019.100207. PMID: 31763175; PMCID: PMC6864135.
  51. Forty L, Ulanova A, Jones L, Jones I, Gordon-Smith K, Fraser C, Farmer A, McGuffin P, Lewis CM, Hosang GM, Rivera M, Craddock N. Comorbid medical illness in bipolar disorder. Br J Psychiatry. 2014 Dec;205(6):465-72. doi: 10.1192/bjp.bp.114.152249. Epub 2014 Oct 30. PMID: 25359927; PMCID: PMC4248234.
  52. Jeppesen R, Benros ME. Autoimmune Diseases and Psychotic Disorders. Front Psychiatry. 2019 Mar 20;10:131. doi: 10.3389/fpsyt.2019.00131. PMID: 30949074; PMCID: PMC6435494.
  53. Roberts AL, Kubzansky LD, Malspeis S, Feldman CH, Costenbader KH. Association of Depression With Risk of Incident Systemic Lupus Erythematosus in Women Assessed Across 2 Decades. JAMA Psychiatry. 2018 Dec 1;75(12):1225-1233. doi: 10.1001/jamapsychiatry.2018.2462. PMID: 30208373; PMCID: PMC6583686.
  54. Andersson NW, Gustafsson LN, Okkels N, Taha F, Cole SW, Munk-Jørgensen P, Goodwin RD. Depression and the risk of autoimmune disease: a nationally representative, prospective longitudinal study. Psychol Med. 2015 Dec;45(16):3559-69. doi: 10.1017/S0033291715001488. Epub 2015 Aug 14. PMID: 26271451.
  55. Frolkis AD, Vallerand IA, Shaheen AA, Lowerison MW, Swain MG, Barnabe C, Patten SB, Kaplan GG. Depression increases the risk of inflammatory bowel disease, which may be mitigated by the use of antidepressants in the treatment of depression. Gut. 2019 Sep;68(9):1606-1612. doi: 10.1136/gutjnl-2018-317182. Epub 2018 Oct 18. PMID: 30337374.
  56. Sparks JA, Malspeis S, Hahn J, Wang J, Roberts AL, Kubzansky LD, Costenbader KH. Depression and Subsequent Risk for Incident Rheumatoid Arthritis Among Women. Arthritis Care Res (Hoboken). 2021 Jan;73(1):78-89. doi: 10.1002/acr.24441. PMID: 32937012; PMCID: PMC7775283.
  57. Chan VKY, Luo H, Chan SSM, Lau CS, Yeung WWY, Peng K, Tong X, Lam MPS, Wong ICK, Li X. Treatment-resistant depression and risk of autoimmune diseases: evidence from a population-based cohort and nested case-control study. Transl Psychiatry. 2023 Mar 3;13(1):76. doi: 10.1038/s41398-023-02383-9. PMID: 36864045; PMCID: PMC9981710.
  58. Heart Disease Facts. Centers for Disease Control and Prevention. 2023.
  59. Henein MY, Vancheri S, Longo G, Vancheri F. The Role of Inflammation in Cardiovascular Disease. Int J Mol Sci. 2022 Oct 26;23(21):12906. doi: 10.3390/ijms232112906. PMID: 36361701; PMCID: PMC9658900.
  60. Diamantis E, Kyriakos G, Quiles-Sanchez LV, Farmaki P, Troupis T. The Anti-Inflammatory Effects of Statins on Coronary Artery Disease: An Updated Review of the Literature. Curr Cardiol Rev. 2017;13(3):209-216. doi: 10.2174/1573403X13666170426104611. PMID: 28462692; PMCID: PMC5633715.
  61. Parsaik AK, Singh B, Murad MH, Singh K, Mascarenhas SS, Williams MD, Lapid MI, Richardson JW, West CP, Rummans TA. Statins use and risk of depression: a systematic review and meta-analysis. J Affect Disord. 2014 May;160:62-7. doi: 10.1016/j.jad.2013.11.026. Epub 2013 Dec 17. PMID: 24370264.
  62. Kim SW, Kang HJ, Jhon M, Kim JW, Lee JY, Walker AJ, Agustini B, Kim JM, Berk M. Statins and Inflammation: New Therapeutic Opportunities in Psychiatry. Front Psychiatry. 2019 Mar 5;10:103. doi: 10.3389/fpsyt.2019.00103. PMID: 30890971; PMCID: PMC6413672.
  63. Haghighi M, Khodakarami S, Jahangard L, Ahmadpanah M, Bajoghli H, Holsboer-Trachsler E, Brand S. In a randomized, double-blind clinical trial, adjuvant atorvastatin improved symptoms of depression and blood lipid values in patients suffering from severe major depressive disorder. J Psychiatr Res. 2014 Nov;58:109-14. doi: 10.1016/j.jpsychires.2014.07.018. Epub 2014 Aug 6. PMID: 25130678.
  64. Gougol A, Zareh-Mohammadi N, Raheb S, Farokhnia M, Salimi S, Iranpour N, Yekehtaz H, Akhondzadeh S. Simvastatin as an adjuvant therapy to fluoxetine in patients with moderate to severe major depression: A double-blind placebo-controlled trial. J Psychopharmacol. 2015 May;29(5):575-81. doi: 10.1177/0269881115578160. Epub 2015 Mar 31. PMID: 25827645.
  65. Köhler O, Gasse C, Petersen L, Ingstrup KG, Nierenberg AA, Mors O, Østergaard SD. The Effect of Concomitant Treatment With SSRIs and Statins: A Population-Based Study. Am J Psychiatry. 2016 Aug 1;173(8):807-15. doi: 10.1176/appi.ajp.2016.15040463. Epub 2016 May 3. PMID: 27138586.
  66. Gutlapalli SD, Farhat H, Irfan H, Muthiah K, Pallipamu N, Taheri S, Thiagaraj SS, Shukla TS, Giva S, Penumetcha SS. The Anti-Depressant Effects of Statins in Patients With Major Depression Post-Myocardial Infarction: An Updated Review 2022. Cureus. 2022 Dec 8;14(12):e32323. doi: 10.7759/cureus.32323. PMID: 36628002; PMCID: PMC9825119.
  67. Leading causes of death. Centers for disease control and prevention. 2023.
  68. Anand P, Kunnumakkara AB, Sundaram C, Harikumar KB, Tharakan ST, Lai OS, Sung B, Aggarwal BB. Cancer is a preventable disease that requires major lifestyle changes. Pharm Res. 2008 Sep;25(9):2097-116. doi: 10.1007/s11095-008-9661-9. Epub 2008 Jul 15. Erratum in: Pharm Res. 2008 Sep;25(9):2200. Kunnumakara, Ajaikumar B [corrected to Kunnumakkara, Ajaikumar B]. PMID: 18626751; PMCID: PMC2515569.
  69. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002 Dec 19-26;420(6917):860-7. doi: 10.1038/nature01322. PMID: 12490959; PMCID: PMC2803035.
  70. Park MH, Hong JT. Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches. Cells. 2016 Mar 29;5(2):15. doi: 10.3390/cells5020015. PMID: 27043634; PMCID: PMC4931664.
  71. Masters CL, Bateman R, Blennow K, Rowe CC, Sperling RA, Cummings JL. Alzheimer's disease. Nat Rev Dis Primers. 2015 Oct 15;1:15056. doi: 10.1038/nrdp.2015.56. PMID: 27188934.
  72. Kinney JW, Bemiller SM, Murtishaw AS, Leisgang AM, Salazar AM, Lamb BT. Inflammation as a central mechanism in Alzheimer's disease. Alzheimers Dement (N Y). 2018 Sep 6;4:575-590. doi: 10.1016/j.trci.2018.06.014. PMID: 30406177; PMCID: PMC6214864.
  73. Xie J, Van Hoecke L, Vandenbroucke RE. The Impact of Systemic Inflammation on Alzheimer's Disease Pathology. Front Immunol. 2022 Jan 6;12:796867. doi: 10.3389/fimmu.2021.796867. PMID: 35069578; PMCID: PMC8770958.
  74. Heneka MT, Golenbock DT, Latz E. Innate immunity in Alzheimer's disease. Nat Immunol. 2015 Mar;16(3):229-36. doi: 10.1038/ni.3102. PMID: 25689443.
  75. Frost GR, Jonas LA, Li YM. Friend, Foe or Both? Immune Activity in Alzheimer's Disease. Front Aging Neurosci. 2019 Dec 10;11:337. doi: 10.3389/fnagi.2019.00337. PMID: 31920620; PMCID: PMC6916654.
  76. Labzin LI, Heneka MT, Latz E. Innate Immunity and Neurodegeneration. Annu Rev Med. 2018 Jan 29;69:437-449. doi: 10.1146/annurev-med-050715-104343. Epub 2017 Nov 6. PMID: 29106805.
  77. Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, Ferrucci L, Gilroy DW, Fasano A, Miller GW, Miller AH, Mantovani A, Weyand CM, Barzilai N, Goronzy JJ, Rando TA, Effros RB, Lucia A, Kleinstreuer N, Slavich GM. Chronic inflammation in the etiology of disease across the life span. Nat Med. 2019 Dec;25(12):1822-1832. doi: 10.1038/s41591-019-0675-0. Epub 2019 Dec 5. PMID: 31806905; PMCID: PMC7147972.
  78. Ferrucci L, Fabbri E. Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. Nat Rev Cardiol. 2018 Sep;15(9):505-522. doi: 10.1038/s41569-018-0064-2. PMID: 30065258; PMCID: PMC6146930.
  79. Liu YZ, Wang YX, Jiang CL. Inflammation: The Common Pathway of Stress-Related Diseases. Front Hum Neurosci. 2017 Jun 20;11:316. doi: 10.3389/fnhum.2017.00316. PMID: 28676747; PMCID: PMC5476783.
  80. Nasef NA, Mehta S, Ferguson LR. Susceptibility to chronic inflammation: an update. Arch Toxicol. 2017 Mar;91(3):1131-1141. doi: 10.1007/s00204-016-1914-5. Epub 2017 Jan 27. PMID: 28130581.
  81. Zhao Y, Forst CV, Sayegh CE, Wang IM, Yang X, Zhang B. Molecular and genetic inflammation networks in major human diseases. Mol Biosyst. 2016 Jul 19;12(8):2318-41. doi: 10.1039/c6mb00240d. PMID: 27303926; PMCID: PMC4955784.
  82. Centritto F, Iacoviello L, di Giuseppe R, De Curtis A, Costanzo S, Zito F, Grioni S, Sieri S, Donati MB, de Gaetano G, Di Castelnuovo A; Moli-sani Investigators. Dietary patterns, cardiovascular risk factors and C-reactive protein in a healthy Italian population. Nutr Metab Cardiovasc Dis. 2009 Dec;19(10):697-706. doi: 10.1016/j.numecd.2008.11.009. Epub 2009 Mar 19. PMID: 19303267.
  83. Kim H, Caulfield LE, Garcia-Larsen V, Steffen LM, Coresh J, Rebholz CM. Plant-Based Diets Are Associated With a Lower Risk of Incident Cardiovascular Disease, Cardiovascular Disease Mortality, and All-Cause Mortality in a General Population of Middle-Aged Adults. J Am Heart Assoc. 2019 Aug 20;8(16):e012865. doi: 10.1161/JAHA.119.012865. Epub 2019 Aug 7. PMID: 31387433; PMCID: PMC6759882.
  84. Al Bander Z, Nitert MD, Mousa A, Naderpoor N. The Gut Microbiota and Inflammation: An Overview. Int J Environ Res Public Health. 2020 Oct 19;17(20):7618. doi: 10.3390/ijerph17207618. PMID: 33086688; PMCID: PMC7589951.
  85. Ma W, Nguyen LH, Song M, Wang DD, Franzosa EA, Cao Y, Joshi A, Drew DA, Mehta R, Ivey KL, Strate LL, Giovannucci EL, Izard J, Garrett W, Rimm EB, Huttenhower C, Chan AT. Dietary fiber intake, the gut microbiome, and chronic systemic inflammation in a cohort of adult men. Genome Med. 2021 Jun 17;13(1):102. doi: 10.1186/s13073-021-00921-y. PMID: 34140026; PMCID: PMC8212460.
  86. Pati S, Irfan W, Jameel A, Ahmed S, Shahid RK. Obesity and Cancer: A Current Overview of Epidemiology, Pathogenesis, Outcomes, and Management. Cancers (Basel). 2023 Jan 12;15(2):485. doi: 10.3390/cancers15020485. PMID: 36672434; PMCID: PMC9857053.
  87. Khanna D, Khanna S, Khanna P, Kahar P, Patel BM. Obesity: A Chronic Low-Grade Inflammation and Its Markers. Cureus. 2022 Feb 28;14(2):e22711. doi: 10.7759/cureus.22711. PMID: 35386146; PMCID: PMC8967417.
  88. Calcaterra V, Vandoni M, Rossi V, Berardo C, Grazi R, Cordaro E, Tranfaglia V, Carnevale Pellino V, Cereda C, Zuccotti G. Use of Physical Activity and Exercise to Reduce Inflammation in Children and Adolescents with Obesity. Int J Environ Res Public Health. 2022 Jun 5;19(11):6908. doi: 10.3390/ijerph19116908. PMID: 35682490; PMCID: PMC9180584.
  89. Metsios GS, Moe RH, Kitas GD. Exercise and inflammation. Best Pract Res Clin Rheumatol. 2020 Apr;34(2):101504. doi: 10.1016/j.berh.2020.101504. Epub 2020 Apr 2. PMID: 32249021.
  90. Kharrazian D. Exposure to Environmental Toxins and Autoimmune Conditions. Integr Med (Encinitas). 2021 Apr;20(2):20-24. PMID: 34377090; PMCID: PMC8325494.
  91. Thompson PA, Khatami M, Baglole CJ, Sun J, Harris SA, Moon EY, Al-Mulla F, Al-Temaimi R, Brown DG, Colacci A, Mondello C, Raju J, Ryan EP, Woodrick J, Scovassi AI, Singh N, Vaccari M, Roy R, Forte S, Memeo L, Salem HK, Amedei A, Hamid RA, Lowe L, Guarnieri T, Bisson WH. Environmental immune disruptors, inflammation and cancer risk. Carcinogenesis. 2015 Jun;36 Suppl 1(Suppl 1):S232-53. doi: 10.1093/carcin/bgv038. PMID: 26106141; PMCID: PMC4492068.
  92. Barouki R, Melén E, Herceg Z, Beckers J, Chen J, Karagas M, Puga A, Xia Y, Chadwick L, Yan W, Audouze K, Slama R, Heindel J, Grandjean P, Kawamoto T, Nohara K. Epigenetics as a mechanism linking developmental exposures to long-term toxicity. Environ Int. 2018 May;114:77-86. doi: 10.1016/j.envint.2018.02.014. Epub 2018 Feb 27. PMID: 29499450; PMCID: PMC5899930.
  93. Tiffon C. The Impact of Nutrition and Environmental Epigenetics on Human Health and Disease. Int J Mol Sci. 2018 Nov 1;19(11):3425. doi: 10.3390/ijms19113425. PMID: 30388784; PMCID: PMC6275017.
  94. Abraham MJ, El Sherbini A, El-Diasty M, Askari S, Szewczuk MR. Restoring Epigenetic Reprogramming with Diet and Exercise to Improve Health-Related Metabolic Diseases. Biomolecules. 2023 Feb 7;13(2):318. doi: 10.3390/biom13020318. PMID: 36830687; PMCID: PMC9953584.
  95. Voisin S, Eynon N, Yan X, Bishop DJ. Exercise training and DNA methylation in humans. Acta Physiol (Oxf). 2015 Jan;213(1):39-59. doi: 10.1111/apha.12414. Epub 2014 Nov 19. PMID: 25345837.
  96. Choi SW, Friso S. Epigenetics: A New Bridge between Nutrition and Health. Adv Nutr. 2010 Nov;1(1):8-16. doi: 10.3945/an.110.1004. Epub 2010 Nov 16. PMID: 22043447; PMCID: PMC3042783.
  97. Mazzone R, Zwergel C, Artico M, Taurone S, Ralli M, Greco A, Mai A. The emerging role of epigenetics in human autoimmune disorders. Clin Epigenetics. 2019 Feb 26;11(1):34. doi: 10.1186/s13148-019-0632-2. PMID: 30808407; PMCID: PMC6390373.
  98. Surace AEA, Hedrich CM. The Role of Epigenetics in Autoimmune/Inflammatory Disease. Front Immunol. 2019 Jul 4;10:1525. doi: 10.3389/fimmu.2019.01525. PMID: 31333659; PMCID: PMC6620790.
  99. Jiang S, Postovit L, Cattaneo A, Binder EB, Aitchison KJ. Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma. Front Psychiatry. 2019 Nov 8;10:808. doi: 10.3389/fpsyt.2019.00808. PMID: 31780969; PMCID: PMC6857662.
  100. Gudsnuk K, Champagne FA. Epigenetic influence of stress and the social environment. ILAR J. 2012;53(3-4):279-88. doi: 10.1093/ilar.53.3-4.279. PMID: 23744967; PMCID: PMC4021821.
  101. Shi Y, Zhang H, Huang S, Yin L, Wang F, Luo P, Huang H. Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials. Signal Transduct Target Ther. 2022 Jun 25;7(1):200. doi: 10.1038/s41392-022-01055-2. PMID: 35752619; PMCID: PMC9233709.
  102. Ohkura N, Sakaguchi S. Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases. Cell Res. 2020 Jun;30(6):465-474. doi: 10.1038/s41422-020-0324-7. Epub 2020 May 4. PMID: 32367041; PMCID: PMC7264322.
  103. Hwang JY, Aromolaran KA, Zukin RS. The emerging field of epigenetics in neurodegeneration and neuroprotection. Nat Rev Neurosci. 2017 May 18;18(6):347-361. doi: 10.1038/nrn.2017.46. Erratum in: Nat Rev Neurosci. 2018 Dec;19(12):771. PMID: 28515491; PMCID: PMC6380351.
  104. Ling C, Rönn T. Epigenetics in Human Obesity and Type 2 Diabetes. Cell Metab. 2019 May 7;29(5):1028-1044. doi: 10.1016/j.cmet.2019.03.009. Epub 2019 Apr 11. PMID: 30982733; PMCID: PMC6509280.
  105. Lu Y, Chan YT, Tan HY, Li S, Wang N, Feng Y. Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy. Mol Cancer. 2020 Apr 27;19(1):79. doi: 10.1186/s12943-020-01197-3. PMID: 32340605; PMCID: PMC7184703.
  106. Vidrascu EM, Bashore AC, Howard TD, Moore JB. Effects of early- and mid-life stress on DNA methylation of genes associated with subclinical cardiovascular disease and cognitive impairment: a systematic review. BMC Med Genet. 2019 Mar 12;20(1):39. doi: 10.1186/s12881-019-0764-4. PMID: 30866842; PMCID: PMC6417232.
  107. Vidrascu EM, Bashore AC, Howard TD, Moore JB. Effects of early- and mid-life stress on DNA methylation of genes associated with subclinical cardiovascular disease and cognitive impairment: a systematic review. BMC Med Genet. 2019 Mar 12;20(1):39. doi: 10.1186/s12881-019-0764-4. PMID: 30866842; PMCID: PMC6417232.
  108. Yehuda R, Lehrner A. Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms. World Psychiatry. 2018 Oct;17(3):243-257. doi: 10.1002/wps.20568. PMID: 30192087; PMCID: PMC6127768.
  109. Beavers KM, Brinkley TE, Nicklas BJ. Effect of exercise training on chronic inflammation. Clin Chim Acta. 2010;411(11-12):785-793. doi:10.1016/j.cca.2010.02.069
  110. Stromsnes K, Correas AG, Lehmann J, Gambini J, Olaso-Gonzalez G. Anti-Inflammatory Properties of Diet: Role in Healthy Aging. Biomedicines. 2021 Jul 30;9(8):922. doi: 10.3390/biomedicines9080922. PMID: 34440125; PMCID: PMC8389628.
  111. Manisalidis I, Stavropoulou E, Stavropoulos A, Bezirtzoglou E. Environmental and Health Impacts of Air Pollution: A Review. Front Public Health. 2020 Feb 20;8:14. doi: 10.3389/fpubh.2020.00014. PMID: 32154200; PMCID: PMC7044178.
  112. Stress in America 2010: Key Findings. 2023.
  113. Stress in America 2019: American Psychological Association. 2023.
  114. Stress in America. American Psychological Association. 2023.
  115. Americans unhappy with family, social, or financial life are more likely to say they feel lonely. Pew Research Center. 2023.
  116. Murthy VH. Our Epidemic of Loneliness and Isolation: The U.S. Surgeon General’s Advisory on the Healing Effects of Social Connection and Community. 2023.
  117. Van Bogart K, Engeland CG, Sliwinski MJ, Harrington KD, Knight EL, Zhaoyang R, Scott SB, Graham-Engeland JE. The Association Between Loneliness and Inflammation: Findings From an Older Adult Sample. Front Behav Neurosci. 2022 Jan 11;15:801746. doi: 10.3389/fnbeh.2021.801746. PMID: 35087386; PMCID: PMC8787084.
  118. Koyama Y, Nawa N, Yamaoka Y, Nishimura H, Sonoda S, Kuramochi J, Miyazaki Y, Fujiwara T. Interplay between social isolation and loneliness and chronic systemic inflammation during the COVID-19 pandemic in Japan: Results from U-CORONA study. Brain Behav Immun. 2021 May;94:51-59. doi: 10.1016/j.bbi.2021.03.007. Epub 2021 Mar 9. PMID: 33705870; PMCID: PMC7939973.
  119. Stress Management and Emotional Health. Cleveland Clinic. 2023.
  120. The Importance of Stress Management in Overall Health. Institute for Natural Medicine. 2023.
  121. PM launches Governments first loneliness strategy. GOV.UK. 2023.
  122. Case A, Deaton A. Rising morbidity and mortality in midlife among white non-Hispanic Americans in the 21st century. Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15078-83. doi: 10.1073/pnas.1518393112. Epub 2015 Nov 2. PMID: 26575631; PMCID: PMC4679063.
  123. Woolf SH, Schoomaker H. Life Expectancy and Mortality Rates in the United States, 1959-2017. JAMA. 2019 Nov 26;322(20):1996-2016. doi: 10.1001/jama.2019.16932. PMID: 31769830; PMCID: PMC7146991.
  124. Andermann A; CLEAR Collaboration. Taking action on the social determinants of health in clinical practice: a framework for health professionals. CMAJ. 2016 Dec 6;188(17-18):E474-E483. doi: 10.1503/cmaj.160177. Epub 2016 Aug 8. PMID: 27503870; PMCID: PMC5135524.
  125. Fusar-Poli P. Integrated Mental Health Services for the Developmental Period (0 to 25 Years): A Critical Review of the Evidence. Front Psychiatry. 2019 Jun 7;10:355. doi: 10.3389/fpsyt.2019.00355. PMID: 31231250; PMCID: PMC6567858.
  126. Colizzi M, Lasalvia A, Ruggeri M. Prevention and early intervention in youth mental health: is it time for a multidisciplinary and trans-diagnostic model for care? Int J Ment Health Syst. 2020 Mar 24;14:23. doi: 10.1186/s13033-020-00356-9. PMID: 32226481; PMCID: PMC7092613.
  127. Garner A, Yogman M; COMMITTEE ON PSYCHOSOCIAL ASPECTS OF CHILD AND FAMILY HEALTH, SECTION ON DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS, COUNCIL ON EARLY CHILDHOOD. Preventing Childhood Toxic Stress: Partnering With Families and Communities to Promote Relational Health. Pediatrics. 2021 Aug;148(2):e2021052582. doi: 10.1542/peds.2021-052582. PMID: 34312296.
  128. Lee H, Slack KS, Berger LM, Mather RS, Murray RK. Childhood Poverty, Adverse Childhood Experiences, and Adult Health Outcomes. Health Soc Work. 2021 Aug 5;46(3):159-170. doi: 10.1093/hsw/hlab018. PMID: 34312679.
  129. Wang K, Liu H, Hu Q, Wang L, Liu J, Zheng Z, Zhang W, Ren J, Zhu F, Liu GH. Epigenetic regulation of aging: implications for interventions of aging and diseases. Signal Transduct Target Ther. 2022 Nov 7;7(1):374. doi: 10.1038/s41392-022-01211-8. PMID: 36336680; PMCID: PMC9637765.


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