Covid-19 Research

Open Access
Research Article
OCLC

Retrospective Analysis of Factors Associated With High Lung-RADS Score in a Population without Heavy Smoking or Family History of Lung Cancer Google Scholar

Read • Cite • Share — permanent Open Access hosting with DOI tracking
Medicine Group
CancerPulmonology
Article Submission Portal

Chi-Shen Chen, Hsien Chung Yu, Chun Hao Yin, Jin-Shuen Chen, Yao Shen Chen and I Shu Chen*

Volume4-Issue12
Dates: Received: 2023-12-23 | Accepted: 2023-12-30 | Published: 2023-12-30
Pages: 1719-1727

Abstract

Background & Aim: Low-dose computed tomography screening for lung cancer is currently targeted at heavy smokers or those with a family history of lung cancer.
This study aimed to identify risk factors for lung cancer in individuals who do not meet current lung cancer screening criteria as stipulated by the Taiwan Health Promotion Agency’s Low-Dose Computed Tomography (LDCT) screening policy.

Methods: A cohort analysis was conducted on 12,542 asymptomatic healthy subjects aged 20–80 years old who voluntarily underwent LDCT scans from January 2016 to December 2021.

Results: Logistic regression demonstrated that several factors, including age over 55 years, female gender, Body Mass Index (BMI) less than 23, previous history of respiratory diseases such as tuberculosis or obstructive respiratory diseases (Chronic Obstructive Pulmonary Disease [COPD], asthma), and respiratory symptoms such as cough or dyspnea, were associated with high-risk lung radiology scores according to LDCT scans.

Conclusion: These findings indicate that risk-based assessments using primary data and questionnaires to identify risk factors other than heavy smoking and family history of lung cancer may improve the efficiency of lung cancer screening.

Key Messages: The present study aimed to identify risk factors for lung cancer among individuals who do not meet the criteria for LDCT lung cancer screening in Taiwan. The study revealed that age, sex, body mass index (BMI), and significant respiratory symptoms were highly associated with high-risk Lung-RADS scores according to LDCT scans. Additionally, individuals with underlying respiratory diseases and high-risk cooking habits were at risk. Early identification of these risk factors may help target screening and preventative measures toward individuals at high-risk of developing lung cancer.

FullText HTML FullText PDF DOI: 10.37871/jbres1857

Certificate of Publication

Copyright

© 2023 Chen CS, et al. Distributed under Creative Commons CC-BY 4.0

How to cite this article

Chen CS, Yu HC, Yin CH, Chen JS, Chen YS, Chen IS. Retrospective Analysis of Factors Associated With High Lung-RADS Score in a Population without Heavy Smoking or Family History of Lung Cancer. J Biomed Res Environ Sci. 2023 Dec 30; 4(12): 1719-1727. doi: 10.37871/jbres1857, Article ID: JBRES1857, Available at: https://www.jelsciences.com/articles/jbres1857.pdf

Subject area(s)

Cancer
Pulmonology

References

  1. de Koning HJ, van der Aalst CM, de Jong PA, Scholten ET, Nackaerts K, Heuvelmans MA, Lammers JJ, Weenink C, Yousaf-Khan U, Horeweg N, van 't Westeinde S, Prokop M, Mali WP, Mohamed Hoesein FAA, van Ooijen PMA, Aerts JGJV, den Bakker MA, Thunnissen E, Verschakelen J, Vliegenthart R, Walter JE, Ten Haaf K, Groen HJM, Oudkerk M. Reduced Lung-Cancer Mortality with Volume CT Screening in a Randomized Trial. N Engl J Med. 2020 Feb 6;382(6):503-513. doi: 10.1056/NEJMoa1911793. Epub 2020 Jan 29. PMID: 31995683.
  2. Gu JZ, Baird GL, Ge C, Fletcher LM, Agarwal S, Eltorai AEM, Healey TT. ACR Lung CT Screening Reporting and Data System, a Systematic Review and Meta-Analysis Before Change in US Preventative Services Taskforce Eligibility Criteria: 2014 to 2021. J Am Coll Radiol. 2023 Aug;20(8):769-780. doi: 10.1016/j.jacr.2023.04.008. Epub 2023 Jun 8. PMID: 37301355.
  3. Potter AL, Bajaj SS, Yang CJ. The 2021 uspstf lung cancer screening guidelines: a new frontier. Lancet respir med. 2021 Jul;9(7):689-691. doi: 10.1016/S2213-2600(21)00210-1. Epub 2021 May 6. PMID: 33965004.
  4.   Houston KA, Henley SJ, Li J, White MC, Richards TB. Patterns in lung cancer incidence rates and trends by histologic type in the united states, 2004-2009. Lung cancer. 2014 Oct;86(1):22-8. doi: 10.1016/j.lungcan.2014.08.001. Epub 2014 Aug 12. PMID: 25172266; PMCID: PMC5823254.
  5. Barta JA, Powell CA, Wisnivesky JP. Global Epidemiology of Lung Cancer. Ann Glob Health. 2019 Jan 22;85(1):8. doi: 10.5334/aogh.2419. PMID: 30741509; PMCID: PMC6724220.
  6. Risch HA, Howe GR, Jain M, Burch JD, Holowaty EJ, Miller AB. Are female smokers at higher risk for lung cancer than male smokers? A case-control analysis by histologic type. Am J Epidemiol. 1993 Sep 1;138(5):281-93. doi: 10.1093/oxfordjournals.aje.a116857. PMID: 8395141.
  7. Risch HA, Howe GR, Jain M, David Burchet J, HOLOWATY EJ, MILLER AB. Lung cancer risk for female smokers. Science. 1994; 263(5151): 1206-8. doi: 10.1126/science.8122096.
  8. Bain C, Feskanich D, Speizer FE, Thun M, Hertzmark E, Rosner BA, Colditz GA. Lung cancer rates in men and women with comparable histories of smoking. J Natl Cancer Inst. 2004 Jun 2;96(11):826-34. doi: 10.1093/jnci/djh143. PMID: 15173266.
  9. Hovanec J, Siemiatycki J, Conway DI, Olsson A, Stücker I, Guida F, Jöckel KH, Pohlabeln H, Ahrens W, Brüske I, Wichmann HE, Gustavsson P, Consonni D, Merletti F, Richiardi L, Simonato L, Fortes C, Parent ME, McLaughlin J, Demers P, Landi MT, Caporaso N, Tardón A, Zaridze D, Szeszenia-Dabrowska N, Rudnai P, Lissowska J, Fabianova E, Field J, Dumitru RS, Bencko V, Foretova L, Janout V, Kromhout H, Vermeulen R, Boffetta P, Straif K, Schüz J, Kendzia B, Pesch B, Brüning T, Behrens T. Lung cancer and socioeconomic status in a pooled analysis of case-control studies. PLoS One. 2018 Feb 20;13(2):e0192999. doi: 10.1371/journal.pone.0192999. PMID: 29462211; PMCID: PMC5819792.
  10. Zang EA, Wynder EL. Differences in lung cancer risk between men and women: examination of the evidence. J natl cancer inst. 1996 Feb 21;88(3-4):183-92. doi: 10.1093/jnci/88.3-4.183. PMID: 8632492.
  11. De Matteis S, Consonni D, Pesatori AC, Bergen AW, Bertazzi PA, Caporaso NE, Lubin JH, Wacholder S, Landi MT. Are women who smoke at higher risk for lung cancer than men who smoke? Am j epidemiol. 2013 Apr 1;177(7):601-12. doi: 10.1093/aje/kws445. Epub 2013 Feb 20. PMID: 23425629; PMCID: PMC3657535.
  12. You D, Wang D, Wu Y, Chen X, Shao F, Wei Y, Zhang R, Lange T, Ma H, Xu H, Hu Z, Christiani DC, Shen H, Chen F, Zhao Y. Associations of genetic risk, bmi trajectories, and the risk of non-small cell lung cancer: a population-based cohort study. BMC Med. 2022 Jun 6;20(1):203. doi: 10.1186/s12916-022-02400-6. PMID: 35658861; PMCID: PMC9169327.
  13. Zhao J, Barta JA, McIntire R, Shusted C, Zeigler-Johnson C, Juon HS. Racial difference in bmi and lung cancer diagnosis: analysis of the national lung screening trial. Bmc cancer. 2022 Jul 19;22(1):797. doi: 10.1186/s12885-022-09888-4. PMID: 35854273; PMCID: PMC9297592.
  14. Jiang L, Sun YQ, Brumpton BM, Langhammer A, Chen Y, Mai XM. Body mass index and incidence of lung cancer in the hunt study: using observational and mendelian randomization approaches. BMC Cancer. 2022 Nov 8;22(1):1152. doi: 10.1186/s12885-022-10215-0. PMID: 36348315; PMCID: PMC9644519.
  15. Mannino DM, Aguayo SM, Petty TL, Redd SC. Low lung function and incident lung cancer in the united states: data from the first national health and nutrition examination survey follow-up. Arch Intern Med. 2003 Jun 23;163(12):1475-80. doi: 10.1001/archinte.163.12.1475. PMID: 12824098.
  16. Lange P, Nyboe J, Appleyard M, Jensen G, Schnohr P. Ventilatory function and chronic mucus hypersecretion as predictors of death from lung cancer. Am Rev Respir Dis. 1990 Mar;141(3):613-7. doi: 10.1164/ajrccm/141.3.613. PMID: 2310094.
  17. Hole DJ, Watt GC, Davey-Smith G, Hart CL, Gillis CR, Hawthorne VM. Impaired lung function and mortality risk in men and women: findings from the renfrew and paisley prospective population study. BMJ. 1996 Sep 21;313(7059):711-5; discussion 715-6. doi: 10.1136/bmj.313.7059.711. PMID: 8819439; PMCID: PMC2352103.
  18. Kim H, Kim HY, Goo JM, Kim Y. Lung cancer ct screening and lung-rads in a tuberculosis-endemic country: the korean lung cancer screening project (k-lucas). Radiology. 2020 Jul;296(1):181-188. doi: 10.1148/radiol.2020192283. Epub 2020 Apr 14. PMID: 32286195.
  19. Kocher F, Hilbe W, Seeber A, Pircher A, Schmid T, Greil R, Auberger J, Nevinny-Stickel M, Sterlacci W, Tzankov A, Jamnig H, Kohler K, Zabernigg A, Frötscher J, Oberaigner W, Fiegl M. Longitudinal analysis of 2293 nsclc patients: a comprehensive study from the tyrol registry. Lung cancer. 2015 Feb;87(2):193-200. doi: 10.1016/j.lungcan.2014.12.006. Epub 2014 Dec 18. PMID: 25564398.
  20. Chen TY, Fang YH, Chen HL, Chang CH, Huang H, Chen YS, Liao KM, Wu HY, Chang GC, Tsai YH, Wang CL, Chen YM, Huang MS, Su WC, Yang PC, Chen CJ, Hsiao CF, Hsiung CA. Impact of cooking oil fume exposure and fume extractor use on lung cancer risk in non-smoking han chinese women. Sci Rep. 2020 Apr 21;10(1):6774. doi: 10.1038/s41598-020-63656-7. PMID: 32317677; PMCID: PMC7174336.
  21. Xue Y, Jiang Y, Jin S, Li Y. Association between cooking oil fume exposure and lung cancer among chinese nonsmoking women: a meta-analysis. Onco targets ther. 2016 May 19;9:2987-92. doi: 10.2147/OTT.S100949. PMID: 27284248; PMCID: PMC4881732.
  22. Yu IT, Chiu YL, Au JS, Wong TW, Tang JL. Dose-response relationship between cooking fumes exposures and lung cancer among chinese nonsmoking women. Cancer res. 2006 May 1;66(9):4961-7. doi: 10.1158/0008-5472.CAN-05-2932. PMID: 16651454.
  23. Ko YC, Cheng LS, Lee CH, Huang JJ, Huang MS, Kao EL, Wang HZ, Lin HJ. Chinese food cooking and lung cancer in women nonsmokers. Am J Epidemiol. 2000 Jan 15;151(2):140-7. doi: 10.1093/oxfordjournals.aje.a010181. PMID: 10645816.
  24. Bigert C, Gustavsson P, Straif K, Pesch B, Brüning T, Kendzia B, Schüz J, Stücker I, Guida F, Brüske I, Wichmann HE, Pesatori AC, Landi MT, Caporaso N, Tse LA, Yu IT, Siemiatycki J, Pintos J, Merletti F, Mirabelli D, Simonato L, Jöckel KH, Ahrens W, Pohlabeln H, Tardón A, Zaridze D, Field J, 't Mannetje A, Pearce N, McLaughlin J, Demers P, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Dumitru RS, Bencko V, Foretova L, Janout V, Boffetta P, Forastiere F, Bueno-de-Mesquita B, Peters S, Vermeulen R, Kromhout H, Olsson AC. Lung cancer risk among cooks when accounting for tobacco smoking: a pooled analysis of case-control studies from europe, canada, new zealand, and china. J occup environ med. 2015 Feb;57(2):202-9. doi: 10.1097/JOM.0000000000000337. PMID: 25654522; PMCID: PMC7508228.
  25. Swanton C, Hill W, Lim E, Lee C, Weeden CE, Augustine M, Chen K, Kuan FC, Marongiu F, Felipe SR, Cha H, Jackset T, Luchtenborg M, Malanchi I Downward J, Carlsten C, Hackshaw A, Litchfield KR, DeGregori J, JamalHanjani M. Lba1 mechanism of action and an actionable inflammatory axis for air pollution induced non-small cell lung cancer: towards molecular cancer prevention. Ann Oncol. 2022; 33: S1413. doi:10.1016/j.annonc.2022.08.046
  26. Liu X, Mubarik S, Wang F, Yu Y, Wang Y, Shi F, Wen H, Yu C. Lung cancer death attributable to long-term ambient particulate matter (pm2.5) exposure in east asian countries during 1990-2019. Front Med (Lausanne). 2021 Oct 15;8:742076. doi: 10.3389/fmed.2021.742076. PMID: 34722581; PMCID: PMC8553966.
  27. Turner MC, Andersen ZJ, Baccarelli A, Diver WR, Gapstur SM, Pope CA 3rd, Prada D, Samet J, Thurston G, Cohen A. Outdoor air pollution and cancer: an overview of the current evidence and public health recommendations. Ca cancer j clin. 2020 Aug 25:10.3322/caac.21632. doi: 10.3322/caac.21632. Epub ahead of print. PMID: 32964460; PMCID: PMC7904962.
  28. Tseng CH, Tsuang BJ, Chiang CJ, Ku KC, Tseng JS, Yang TY, Hsu KH, Chen KC, Yu SL, Lee WC, Liu TW, Chan CC, Chang GC. The relationship between air pollution and lung cancer in nonsmokers in taiwan. J Thorac Oncol. 2019 May;14(5):784-792. doi: 10.1016/j.jtho.2018.12.033. Epub 2019 Jan 18. PMID: 30664991.

Comments

Publish with JBRES — Peer-reviewed, multidisciplinary Open Access with rapid review, DOI, and global visibility.
Double-Blind CrossRef DOI Discoverable
Submit Manuscript Membership