Hypoxic Epicardium Contribution to Myocardial Repair

Dergilev Konstantin V; Menshikov Mikhail Yu*; Parfyonova Yelena V

**Dergilev Konstantin V, Menshikov Mikhail Yu* and Parfyonova Yelena V**

Volume4-Issue11
Dates: Received: 2023-10-30 | Accepted: 2023-11-12 | Published: 2023-11-14
Pages: 1552-1556

Abstract

Epicardium, the outer epithelial layer of the heart forming from extracardiac primordium, plays a fundamental role in myocardial embryogenesis by generating epicardial-derived cells (cardiac fibroblasts, mesenchymal cells, vascular smooth muscle cells). In the adult heart, epicardium occurs as a mesothelial layer, which, in injured heart, recalls its “embryonic program” and transforms into mesenchymal cells contributing, by such a way, to myocardial reparation. This process is facilitated by hypoxic conditions arising during injury. In general, regulation of this process may be a potential methodology for treatment of cardiovascular diseases.

FullText HTML FullText PDF DOI: 10.37871/jbres1829

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How to cite this article

Dergilev KV, Menshikov MY, Parfyonova YV. Hypoxic Epicardium Contribution to Myocardial Repair. J Biomed Res Environ Sci. 2023 Oct 14; 4(11): 1552-1556. doi: 10.37871/jbres1829, Article ID: JBRES1829, Available at: https://www.jelsciences. com/articles/jbres1829.pdf

Subject area(s)

Cardiovascular Diseases

Clinical Cardiology

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