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Placental Exosomes Trigger Maternal Inflammation and Vascular Dysfunction in Preeclampsia

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Open Access
Article Type Mini Review
Subject Medicine Group
OCLC 9385855305
Olufunke O Arishe*, Abbi Lane-Cordova and R. Clinton Webb
Issue: Volume2-Issue12
Pages: 1211-1215
Received: 2021-12-17
Accepted: 2021-12-20
Published: 2021-12-21

Abstract

Preeclampsia is a pregnancy-specific disease associated with inadequate placental formation, chronic inflammation, and maternal vascular dysfunction. Preeclampsia affects about 5-8% of pregnant women and it is a prevalent cause of maternal mortality. The level and composition of exosomes in the maternal circulation are altered in preeclampsia, and studies have shown that the major source of this greater level of exosomes is the placenta. We propose that exosomal contents from the placenta trigger maternal inflammation and vascular dysfunction, thereby exacerbating the disease progression. This mini-review will focus on the content of placental exosomes and how they could contribute to the development of preeclampsia.

FullText HTML FullText PDF DOI: 10.37871/jbres1374 Crossmark

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© 2021 Arishe OO, et al. Distributed under Creative Commons CC-BY 4.0 Creative CommonsAttribution

How to cite this article

Arishe OO, Lane-Cordova A, Webb RC. Placental Exosomes Trigger Maternal Inflammation and Vascular Dysfunction in Preeclampsia. J Biomed Res Environ Sci. 2021 Dec 21; 2(12): 1211-1215. doi: 10.37871/jbres1374, Article ID: JBRES1374, Available at: https://www.jelsciences.com/articles/jbres1374.pdf

Subject area(s)

Womens Health and CareGynecologyCardiovascular Diseases

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