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Low-Density Lipoprotein Cholesterol (LDL-C) remains a key target in preventing and treating cardiovascular disease. Recent data and expert consensus increasingly support aggressive LDL-C lowering strategies, with emerging evidence suggesting that levels below 30 mg/dL (ultralow/ UL) may provide significant clinical ben…

The global burden of chronic diseases, particularly obesity, diabetes, and cardiovascular diseases, continues to rise. While pharmacological interventions, such as Semaglutide, provide short-term benefits in weight management and glycaemic control, they present limitations, including high costs, side effects, and limit…

Background: The drivers for satisfaction of patients after spinal surgeries are largely unknown and potentially responsive to non-medical factors. We investigated medical and non-medical drivers for patient satisfaction and fulfillment of expectations after spinal surgery.Methods: We performed a questionnaire-based pos…

The objective is to show that the known features of global average sea-level over the last 120,000 years can be accounted for by eleven periodic functions associated with planetary orbits – the hypothesis. The method shows that proxy data for relative global average sea-level during the last glacial cycle, with error…

Objective: The primary objective of this study is to develop a QoS-aware task scheduling algorithm for LoRaWAN IoT applications using a Reinforcement Learning (RL) approach.Introduction: LoRaWAN is a widely adopted Low Power Wide Area Network (LPWAN) protocol designed for Internet of Things (IoT) applications due to it…

Background: Mesenchymal Stem Cell (MSC) therapy has garnered increasing attention as a novel therapeutic strategy for Type 2 Diabetes Mellitus (T2DM), owing to its immunomodulatory and regenerative properties. However, the long-term efficacy of a single intravenous MSC infusion on glycemic control remains insufficientl…

Objective: This study aimed to investigate the synergistic effects of Ergothioneine (EGT) and Tyrosine-Arginine Peptide (TAP) in promoting β-endorphin production in the skin, aiming to alleviate stress-induced dermatological disorders.Method: An optimal ratio between EGT and TAP for β-endorphin stimulation was ascert…

While conventional treatments remain central to cancer care, emerging evidence suggests that complementary strategies may modulate tumor progression. This paper outlines an integrated approach that includes detoxification, exercise, nutritional modifications, immune system support, and the use of certain natural compou…

Cardiac surgery with Cardiopulmonary Bypass (CPB) induces postoperative immunological responses in patients. We aimed to determine changes in various immunological parameters in patients during and after cardiac surgery supported by CPB and to search for possible reliable predictors of postoperative bacterial infection…

Pregnancy is well known to cause further progression of the clinical symptoms of Ménière’s disease. However, mild low-tone hearing loss and ear fullness, similar to the hearing impairment of Ménière’s disease, is often recognized in the ears of pregnant women who are not originally impaired. These phenomena see…

Orthodontic tooth movement is considered as a biological response to the orthodontic stretch via the osteoblast and osteoclast processes. Orthodontic stretch leads to strain in the periodontal ligament, circulatory disturbances, and vascular changes of the periodontal tissue, which cause a hypoxic environment in local …

As Artificial Intelligence (AI), quantum intelligence, and deep technologies advance rapidly, human cognitive flexibility, emotional resilience, and adaptability are experiencing a significant decline. AI excels in optimization, automation, and efficiency, yet has not fostered human cognitive regeneration, worse hinder…

Migratory birds require one or more stopover sites to refuel during their migration journeys between breeding and wintering sites. Many migratory birds have suffered population decline due to habitat loss and degradation at key stopover sites. This issue is particularly pronounced for migratory shorebirds in the East A…

Moringa oleifera is a nutrient-rich plant which is cultivated in different regions of Bangladesh. The plant has a number of medicinal as well as dietary benefits. In light of this information, an epidemiological survey has been conducted on 600 (six hundred) participants from the urban and semi-urban regions of Bogra r…

NMDAR antagonists, such as memantine and ketamine, have demonstrated efficacy in treating neurodegenerative diseases and major depression. Our recent findings reveal that these antagonists significantly enhance 20S proteasome activity, which is essential for degrading intrinsically disordered, oxidatively damaged, or m…