Vasculopathy is a prevalent complication that may appear in the early stage of Systemic Sclerosis (SSc). Traditional Chinese medical prescription-Yiqihuoxue formula (YQHX) has been used as a therapeutic option for SSc in our department, which has acquired a significant treatment effect. We interrogated the role of the YQHX on Vasculopathy with SSc by investigating its effects on the HDMECs from H2O2 injury. The viability of the HDMECs which were induced by H2O2 and then impacted by the YQHX was noticeably more than that of the H2O2-induced HDMECs, while the apoptosis cell percentage was significantly lower. The YQHX could promote cell proliferation and inhibit apoptosis which meant it could protect HDMECs from H2O2 injury. And the tube formation assay shown that the YQHX may have a promoted effects on angiogenic properties of HDMECs. Our data demonstrated that the YQHX is helpful on alleviating vasculopathy. These data help in directing personalized therapeutic approaches in SSc.