In this study the effects of gamma radiations with compounds are an important subject in the field of medicine, radiation shielding and radiation physics. With technological advances the using of radiation has increased in the medicine in the last century. The mass absorpsion coefficient (µ/ρ) is the fundamental a quantity characterizing gamma ray and is of major importance in radiation shielding. In this study, the mass absorption coefficient of painkillers named Ketoprofen, Flurbiprofen, Etodolac, Ibuprofen, Meloxicam, Diclofenac and Aspirin were calculated at energy range from 4.65 keV to 59.543 keV using the WinXCom data programme. In addition total atomic (σta), moleculer (σtm), electronic cross-section (σte), effective atomic number (Zeff), effective electron density (Neff) were calculated.