Endocrinology & Metabolic Disorders
Section Editors
Research Topics in this Section
Clinical Endocrinology
14
Clinical EndocrinologyThese topics are filtered from our journals helping to discover the community within the widespread of multi…
Diabetes
18
DiabetesThese topics are filtered from our journals helping to discover the community within the widespread of multi-disciplinary …
Metabolic Syndromes
14
Metabolic SyndromesThese topics are filtered from our journals helping to discover the community within the widespread of multi-di…
Metabolism
20
MetabolismThese topics are filtered from our journals helping to discover the community within the widespread of multi-disciplinar…
Nanomedicine
3
NanomedicineThese topics are filtered from our journals helping to discover the community within the widespread of multi-disciplin…
Recent Articles
47 articles
Open Access
Case Report 27 Apr 2026
Sustained 48% Weight Loss with Muscle Preservation and 80% Visceral Fat Reduction Over 4 Years: A Case Report
Background: Long-term data on lifestyle interventions in severe obesity beyond 1–2 years are scarce. This case documents 4-year outcomes of Intensive Lifestyle Modification (ILM) with Meal Replacement (MR), emphasizing t…
10 Views 48 Downloads
Open Access
Research Article 16 Mar 2026
CGM-Derived Glucose Phenotyping Reveals Hidden Prediabetes Risk and Reactive Hypoglycemia in Thai Adults with Central Obesity: A Machine Learning Approach
Background: Abdominal obesity is a major driver of metabolic dysfunction, yet conventional screening methods fail to capture dynamic glycemic abnormalities. CGM-based phenotyping in non-diabetic, centrally obese Southeas…
11 Views 62 Downloads
Open Access
Research Article 28 Nov 2025
Features of Vitamin D and Bone Metabolism in Patients with Cirrhosis of Non-Alcoholic and Non-Viral Etiology: Results of a Pilot Study
Background: Liver Cirrhosis (LC) is associated with significant bone metabolic disorders and an increased risk of fractures. While the problem is recognized, data on vitamin D metabolism and bone remodeling in patients w…
89 Views 68 Downloads
Open Access
Review Article 11 Nov 2025
Keto Diet May Worsen Coronary Artery Disease: Insights from Bethsaida Hospital’s Plant-Based Diet Experience
The ketogenic (keto) diet, characterized by high fat, moderate protein, and minimal carbohydrate intake, has surged in popularity due to its perceived efficacy in rapid weight loss. Nevertheless, accumulating evidence hi…
746 Views 64 Downloads
Open Access
Research Article 28 Oct 2025
The High Prevalence of Thyroid Goiter among Arab Minorities in Israel - A Possible Hereditary Connection
Background: Thyroid goiter is endemic in certain world areas, especially with low Iodine supply. Genetic predisposition with the combination of various environmental factors have been suggested as risk factors for thyroi…
209 Views 81 Downloads
Open Access
Review Article 27 Oct 2025
Food, Agriculture, Environment and Chronic non-communicable diseases: How are they connected?
The evolution of modern humans dates from around three million years ago. This period has encompassed cycles of climate change and food availability. Human physiology has adapted to these evolutionary stimuli, and this i…
195 Views 81 Downloads 1 Citation
Open Access
Case Report 15 Oct 2025
Cis-platin Plus Paclitaxel Treatment in Cervical Carcinoma induce Hyperthyroidism: A Case Report
A patient in their 70s with cervical carcinoma developed hyperthyroidism after receiving treatment with cisplatin and paclitaxel. Laboratory tests confirmed the patient’s hyperthyroid status. Following the administrati…
321 Views 85 Downloads
Open Access
Original Article 28 Jul 2025
Molecular Investigation of Cytochrome P-450 Enzymes Inductors
Cytochrome P-450 enzymes play a critical role in xenobiotic metabolism and homeostasis, with their induction offering therapeutic potential for liver diseases and metabolic disorders. Using molecular docking and statisti…
240 Views 81 Downloads
Open Access
Original Article 20 Jun 2025
Re-evaluating Intra-Islet Paracrine Signaling: Precision, Pulsatility and the Path toward Mechanistic Clarity
The pancreas regulates glucose homeostasis through the rhythmic secretion of insulin and glucagon into the portal circulation-an essential process that is disrupted early in the pathogenesis of type 2 diabetes. While the…
733 Views 84 Downloads
Open Access
Opinion 16 Jun 2025
Bridging Innovation and Care in Endocrinology: The Evolving Landscape of Metabolic Health
18 Views 89 Downloads
Open Access
Retrospective Cohort Study 08 Jun 2025
Duodenal Exclusion in the Regulation of Glycemia in Type 2 Diabetic Patients Submitted to Gastrectomy with Roux-en-Y by Gastric Cancer: Cohort Study
Background: The effect of the duodenal exclusion in glycemic regulation has yet to be defined. Individuals with type 2 Diabetes Mellitus (T2DM) operated for other reasons than obesity, represent an adequate model to anal…
450 Views 46 Downloads
Open Access
Research Article 15 Apr 2025
Long-Term Efficacy of a Single Intravenous MSC Infusion on HbA1c Reduction in Type 2 Diabetic Mellitus
Background: Mesenchymal Stem Cell (MSC) therapy has garnered increasing attention as a novel therapeutic strategy for Type 2 Diabetes Mellitus (T2DM), owing to its immunomodulatory and regenerative properties. However, t…
1,033 Views 110 Downloads
Open Access
Review Article 20 Dec 2024
Interplaying Role of Epigenetic, Exercise and Nutrition in Metabolic Diseases
It is important to understand the interplay of epigenetic changes, exercise and nutrition associated with the development of obesity and type-2 diabetes because it offers insights into how environment and lifestyle facto…
2,752 Views 133 Downloads
Open Access
Short Communication 25 Nov 2024
Potato Derived Exosome Nanoparticles as Anti Inflammation Agents
The screening of exosomes from various sources reveals that potato-derived exosomes exhibit the most significant anti-inflammatory activity, as demonstrated by RT-PCR analyses of Tumor Necrosis Factor expression in exoso…
698 Views 127 Downloads 2 Citations
Open Access
Research Article 27 Oct 2024
Rapid HbA1c Reduction May Reduce Diabetes-Related Complications in Patients with Severe Hyperglycemia
Aims: To investigate whether a rapid reduction in HbA1c is more effective for reducing diabetes-related complications and mortality than a gradual approach in patients with severe hyperglycemia.Methods: This retrospectiv…
1,179 Views 113 Downloads 1 Citation
Open Access
Research Article 07 Oct 2024
Glycemic Matrix and Segmentation: A New Metabolic Visualization and Analysis Tool
New technologies arise the opportunity to understand the complex systemic background of multidimensional diseases and allow a personalized approach. Continuous Glucose Monitoring (CGM) sensors and their broad use have be…
346 Views 149 Downloads
Open Access
Mini Review 20 Sep 2024
Hypothyroidism Revisited: Defining the Subgroups on Optimal Thyroxine Replacement Who Have Persisting Symptoms
Hypothyroid patients on optimal replacement but with persisting symptoms continue to be a challenge for their treating physicians. This commentary is based on a substantial clinical experience with this subpopulation.Wit…
628 Views 98 Downloads 1 Citation
Open Access
Research Article 12 Aug 2024
Sex Hormone-Binding Globulin as more than a Biomarker of Metabolic Diseases and Reproductive Disorders: What Physicians Should Know?
Until recent years, Sex Hormone-Binding Globulin (SHBG) has been considered of less a priority in the management of metabolic and chronic inflammatory states. However, emerging research highlights the remarkable role of …
280 Views 125 Downloads
Open Access
Research Article 28 Jun 2024
Short-Chain Fatty Acids Suppress MCP-1 and Cellular Aging Induced by Lipopolysaccharides under High-Concentration Glucose
Background: High glucose levels, as observed in diabetic patients, enhances the inflammatory response of Porphyromonas gingivalis-Lipopolysaccharide (Pg-LPS) in various cell types and may thus worsen atherosclerosis and …
253 Views 113 Downloads
Open Access
Short Communication 14 Jun 2024
Endocrinologists - Do You Remember Woltmans Sign? The Delayed Reflexes of Overt Hypothyroidism also occur with T3 Deficiency
Woltman’s Sign, the delay in the relaxation phase of the Achilles reflex, has long been recognised as the hallmark of overt hypothyroidism. It is most easily observed with the ankle jerk [1] but delayed relaxation can …
6,539 Views 112 Downloads
Open Access
Short Communication 11 Jun 2024
TRPM7-Mediated Ca2+ Influx in Metabolic Reprograming
Metabolic reprograming is a process in which cells alter their biosynthetic and bioenergetic pathways to meet the changing energetic demands. To ensure energy supply, cancer cells increase glucose uptake and adapt their …
406 Views 85 Downloads
Open Access
Short Communication 28 May 2024
Prebiotic Fucoidan Potentially Improves Gut Microbiota and Metabolism in Long-Cared Elderly People with Malnutrition
The gut-microbiota-targeted prebiotic intervention has been a hot topic in the study of health modulation. To examine the effect of fucoidan supplementation on the health of long-cared elderly subjects (88years ± 3.41) …
1,080 Views 132 Downloads
Open Access
Research Article 22 May 2024
Punica granatum Bioactive Compounds-Loaded Chitosan Nanoparticles Exhibit Potent Antihyperglycemic Effect in Alloxan-Induced Diabetic Mice
In the current study, alloxan-induced diabetic mice model was used to assess the antihyperglycemic effects of Chitosan Nanoparticles (CSNP) loaded with (Punica granatum methanol extract-PG) bioactive compounds. Analysis …
428 Views 110 Downloads 1 Citation
Open Access
Opinion 07 May 2024
The Glucose-Fatty Acid Cycle: An Old Concept that Never Goes out of Fashion
6,609 Views 95 Downloads
Open Access
Research Article 17 Nov 2023
Network Pharmacology Study of Huangqi-Huangjing in the Treatment of Diabetic Nephropathy and Diabetic Cardiomyopathy
Objective: To systematically investigate the mechanism of Huangqi-Huangjing in the treatment of Diabetic Nephropathy (DN) and Diabetic Cardiomyopathy (DC) using network pharmacology and molecular docking analysis. To pro…
1,204 Views 121 Downloads
Open Access
Brief Communication 26 Apr 2023
Development of Ratiometric Fluorescence Sensing Molecule for Caspase-14, a Key Enzyme of Epidermis Metabolism
Skin is the vastest organ harboring principle functions to protect from external stimuli and internal moisture desorption. The loss of functions might bring about diseases and senescence and well maintained metabolisms a…
787 Views 85 Downloads 2 Citations
Open Access
Research Article 08 Mar 2023
Metabolomic Methods to Predict Cancer-Associated Skeletal Muscle Wasting from Profiles of Urinary Metabolites
It is known that cachexia is a cancer-associated muscle wasting and reduction in the function status due to treatment especially chemotherapy and in life expectancy, to assess cachexia muscle loss there are many methods …
581 Views 43 Downloads
Open Access
Research Article 31 Jan 2023
Correlates of Erectile Dysfunction among Diabetic Patients Attending Kinshasa Hospitals, the Democratic Republic of the Congo
Objective: We assessed the frequency of erectile dysfunction and associated risk factors among diabetic patients attending Kinshasa hospitals.Methods: We enrolled 205 male diabetic patients (mean age: 53 ± 11 years) fro…
919 Views 112 Downloads
Open Access
Short Communication 28 Dec 2022
Diabetes: Its Complications and Inflammation Markers
Type 2 Diabetes (T2DM) is a chronic inflammatory metabolic disease of high prevalence around the world. The elevated inflammation markers such as Neutrophil Lymphocyte Ratio (NLR), and Platelet Lymphocyte Ratio (PLR) are…
655 Views 95 Downloads
Open Access
Mini Review 12 Dec 2022
Regulation of Amino Acid Metabolism in Hematological Malignancies: Advances from Transcriptomics and Metabolomics
Tumor cells use amino acids to rewire metabolic pathways to meet increased demands for energy, reducing equivalents, and cellular biosynthesis. Aside acting as building blocks for protein synthesis, amino acids also func…
807 Views 79 Downloads
Open Access
Review Article 30 Nov 2022
Implications of Plant Foods in Weight Management: Focus on Metabolic Health
Plant foods are important component of human diet and they are excellent source health-promoting compounds, such as amino acids, dietary fibers, complex carbohydrates, unsaturated fatty acids, as well as minerals and vit…
1,710 Views 91 Downloads 1 Citation
Open Access
Research Article 22 Nov 2022
Increase of Consultations for Premature Thelarche and the Post-Diagnostic of Precocious and Accelerated Puberty in Pediatric Endocrinology in Alava, due to the Confinement Measures Endured in 2019 due to the COVID-19 Pandemic
Introduction: Due to the COVID 19 pandemic and home confinement measures, many of our routine and daily habits have been both affected and modified. Have these factors conditioned a real increase in Precocious (PP) and A…
4,282 Views 85 Downloads 1 Citation
Open Access
Research Article 15 Aug 2022
Antibacterial Effect of Graphene-Collagen Nanocomposites on Salmonella species
The aim of this report is to summarize the applicability of nanocomposites against clinically significant pathogen Salmonella entherica serotype holeraesius. The antibacterial effect of single SiO2, RGO nanoparticles and…
5 Views 85 Downloads
Open Access
Review Article 19 Jul 2022
Inflammation and Diabetic Kidney Disease: New Perspectives
Diabetic Kidney Disease (DKD) can occur in approximately 30-40% of the population with type 1 or 2 diabetes mellitus around the world. In the pathogenesis and progression the Diabetic Kidney Disease (DKD), three fundamen…
1,301 Views 94 Downloads 6 Citations
Open Access
Mini Review 18 May 2022
Review: The Commonality of Energy Metabolism of Starvation, Disorders of Glucose-Lipid Metabolism, Diabetes Mellitus and Cachexia
Diabetes mellitus, pathoglycemia, dyslipidemia, non-alcoholic fatty liver, overweight, hypertension, and atherosclerosis are common diseases endangering human health. Cachexia is a life-threatening disease condition. Cac…
1,832 Views 93 Downloads 1 Citation
Open Access
Short Communication 08 Apr 2022
A Conceptual Model of Nickel Content in the Bodies of Seafood Mollusks and their Gastrointestinal Absorption
There are many biomonitoring studies of nickel in the mollusks, but to understand how the nickel is accumulated in the human body and the health risk posed by the metal is not a straightforward formula. Therefore, the ai…
2,008 Views 42 Downloads
Open Access
Review Article 25 Mar 2022
Simple Review of Environmental Analytic Methods for the Determination of Pesticide Metabolites
The findings of research proceedings on pesticide metabolites detection are both an environmental inventory and prevention of potential foodstuffs contaminants. Since, the requirement of a quality environment is a condit…
2,380 Views 85 Downloads
Open Access
Case Report 11 Mar 2022
Compressive Non-Toxic Intrathoracic Goiter in Patient with Contraindication to Surgical Treatment: Case Report
Introduction: Thyroidectomy is the treatment of choice for non-toxic compressive Multinodular Goiter (MNG). However, when surgery is contraindicated, other therapeutic options should be evaluated. In this case report, no…
4,035 Views 86 Downloads
Open Access
Research Article 20 Jan 2022
Prevalence and Patterns of Herbal Medicine Use among Type 2 Diabetes Mellitus Patients at the University Teaching Hospitals in Lusaka
Background: In 2015, Zambia reported 218,200 instances of Diabetes Mellitus (DM) with 8,232 diabetes-related fatalities. Insulin therapy and oral antidiabetic medications are two pharmacological therapies used to treat d…
3,335 Views 100 Downloads 11 Citations
Open Access
Research Article 27 Aug 2021
Incidence and Costs of Hypoglycemia among Type II Diabetes Mellitus Patients in Turkey
We aimed to determine the lifetime and one-year incidence of hypoglycemia in adults who had been treated following a diagnosis of Type II Diabetes Mellitus (T2DM), the factors that affected this incidence, and its effect…
4 Views 83 Downloads 1 Citation
Open Access
Review Article 06 May 2021
A Literature Review of Anti- Diabetic Medicinal Plant Properties (Costus speices)
Costus species is a significant restorative and decorative plant used to fix various illnesses. In India 6,000 plants are used for traditional and herbal medicine. The plant Costus spicatus commonly known as ‘Spiral gi…
6,405 Views 92 Downloads 1 Citation
Open Access
Review Article 13 Apr 2021
Modeling Metabolic Diseases with Organoids: A Review
An organoid is a functional unit of any given organ capable of reproducing under culture, as well as a biological structure similar in both function and structure to its in vivo equivalent. They are miniature-sized funct…
1,752 Views 94 Downloads 2 Citations
Open Access
Opinion 06 Mar 2021
Does Lyme Disease Cause PANS?
In 1994, Susan Swedo and colleagues described children who developed mental health issues following infection with Group A Streptococcus (GAS) infections, and in a subsequent report coined the term Pediatric Autoimmune N…
2,067 Views 246 Downloads
Open Access
Case Report 02 Mar 2021
Lifestyle, Nutritional and Psychological Changes in Adult Patients with Inborn Errors of Metabolism during COVID 19 Pandemic: Results from an Online Survey
When COVID-19 pandemic out broke in Italy, during the lockdown from March to May 2020, Inborn Errors of Metabolism (IEM) patients were at risk of not getting their dietary special products and routine visits. Moreover, d…
6,022 Views 234 Downloads
Open Access
Review Article 15 Dec 2020
Metabolic Disturbance in Patients with Muscular Dystrophy and Reflection of Altered Enzyme Activity in Dystrophic Muscle: One Critical View
Muscular dystrophies are inherited myogenic diseases and considered by progressive muscle wasting and weakness with variable distribution and severity. The essential characteristics of muscular dystrophies are selective …
3,535 Views 277 Downloads 4 Citations
Open Access
Research Article 30 Nov 2020
Association of Serum Ferritin and Inflammatory Biomarkers with Insulin Resistance in Chinese Type 2 Diabetes Mellitus Patients
Objective: Obesity-induced Insulin Resistance (IR) is one of the main causes of Type 2 Diabetes Mellitus (T2DM) and accompanies the progression of T2DM. Serum Ferritin has been shown to be associated with IR. Inflammatio…
3,328 Views 586 Downloads
Open Access
Case Report 11 Nov 2020
Integrated Yoga and Naturopathy Management (IYNM) of Obesity: A Case Report
A 45-year-old male patient with the nature of sedentary lifestyle, diagnosed with obesity (BMI-33.2 kg/m2) since 2013, was visited for Integrated Yoga and Naturopathy Management (IYNM) for the weight reduction in our hos…
2,886 Views 289 Downloads