The screening of exosomes from various sources reveals that potato-derived exosomes exhibit the most significant anti-inflammatory activity, as demonstrated by RT-PCR analyses of Tumor Necrosis Factor expression in exosome-treated HaCaT cells. Exosomes extracted from potatoes are nanoparticles averaging 66 nm in diameter and possess the ability to actively infiltrate cells. In an Ex-vivo model of concanavalin A-treated mouse Th1 cells for autoimmune hepatitis, exosomes produced from potatoes significantly inhibit the production of Interferon gamma. Our studies highlight the significant potential of exosomes from potatoes for cosmetic and medicinal uses.