Background : Efficient bronchodilator delivery plays a crucial role in managing both acute and chronic respiratory conditions, particularly in high-stakes environments like emergency departments and intensive care units, where timely intervention is essential. vibrating mesh nebulizers (VMNs) are able to function on the basis of a vibrating mesh with microscopic holes that generate aerosolized particles, therefore offering much more consistent and efficient medication compared to Jet Nebulizers (JNs).

Objectives: This systematic review aimed to evaluate the efficacy of VMNs compared to jet nebulizers for management chronic respiratory diseases.
Methods: Four electronic databases, PubMed, Cochrane, Web Science, and Google Scholar were thoroughly searched to conduct a comprehensive literature review from 1st january 2017 till 31st december 2023. The International Prospective Register of Systematic Reviews (CRD42024507795) contains a record of the registered protocol.

Results: We identified 411 studies during the initial search; 9 studies (2.2 %) met the inclusion criteria and were included in the systematic review. The review demonstrates that VMNs offer significant advantages over jet nebulizers across various clinical settings.

Conclusion: VMNs provide better lung deposition, more efficient drug delivery, and superior clinical outcomes, particularly in the management of asthma and COPD. Additionally, VMNs are associated with fewer adverse effects and greater patient comfort, which may contribute to improved compliance and treatment success.