The outbreak of monkeypox, a zoonotic viral disease, necessitates effective strategies for infection control and decontamination. Ultraviolet-C (UV-C) radiation, with its germicidal properties, has long been utilized for sterilization in various settings. This paper explores the potential of UV-C technology in managing the monkeypox epidemic, focusing on its applications for surface, air, and Personal Protective Equipment (PPE) decontamination. Traditional UV-C methods have demonstrated effectiveness in reducing viral loads on surfaces and in the air, potentially mitigating the spread of monkeypox. Additionally, UV-C can aid in the sterilization of PPE, crucial for protecting healthcare workers and managing supply shortages. The paper also addresses environmental considerations, including the energy consumption and water footprint associated with UV-C systems. The transition to energy-efficient UV-C LEDs and sustainable practices is highlighted as a means to balance efficacy with environmental impact. By integrating UV-C technology with other infection control measures, healthcare facilities and high-risk environments can enhance their response to the monkeypox epidemic while minimizing ecological concerns.