Human Immunodeficiency Virus (HIV)-1 is the cause of Acquired Immunodeficiency Syndrome (AIDS). Due to advances in clinical management, HIV/AIDS is now regarded a chronic disease instead of terminal disease. However, non-adherence is a challenge in effective management of HIV/AIDS. Non-adherence is classified into intentional and unintentional non-adherence Interactive toxicity belief is now one of the main factors that promotes non-adherence among HIV patients. Detecting non-adherence is an essential component of managing this phenomenon. A number measures has been proposed on how to manage non-adherence Optimum non-adherence-preventing measures should be holistic that involve different strategies. This review suggest MIB+ model for tackling non-adherence among HIV/AIDS patients. We also need to have more understanding on how stigma implicates non-adherence.