Transthyretin Cardiac Amyloidosis (ATTR-CA) is caused by the deposition of misfolded transthyretin fibrils, leading to restrictive cardiomyopathy and eventually death if untreated. ATTR-CA is associated with certain musculoskeletal conditions, notably carpal tunnel syndrome, lumbar spinal stenosis, nontraumatic biceps tendon rupture, trigger finger and hip, knee and shoulder arthropathies. These musculoskeletal manifestations could provide a clue and potentially help in the timely diagnosis of ATTR-CA.