Background: In the twenty-first century, female adolescents’ use of intravenous psychoactive substances has become widespread worldwide. For instance, statistics show that 155 and 250 million people between the ages of 15-64 used intravenous psychoactive drugs as of 2008. Examples of intravenous psychoactive drugs taken by people with 15-64 include; Amphetamines, non-prescribed psychoactive prescription drugs, cannabis, cocaine, and opiates. As a result of the preceding, the use of intravenous psychoactive drugs among Female adolescents is a common phenomenon in the 21st century.

Aim: To undergo a systematic review on IV psychoactive drugs use, prevalence, causes and effects among adolescent females.

Design: A systematic review.

Data Sources: Systematic search for worldwide published literature from databases like google scholar, Emerald, PubMed, and science-direct.
Study Eligibility Criteria: Articles that are published in English, primary research and studies published within the last 10 (ten) years (2013-2023).

Results: From the 2000 published papers that was found, 1700 publications were screened out owing to duplicate data. In addition, 60 publications were eliminated because they did not have appropriate information for this current study, and 200 papers were eliminated because of erroneous information. For being overly shallow, 29 publications were ignored. In the end, this study included 11 (eleven) publications.

Conclusion: Worldwide, there is a high prevalence of female adolescents using intravenous psychoactive drugs. The causes include feelings of helplessness following family separation, poor academic performance, a physical environment, prior substance use, recreational alternatives, socialisation issues, and inadequate organisational support. Cardiovascular illness, psychological diseases like anxiety, dependency, mood, and psychosis disorders, as well as various Hormonal Contraceptives, are all consequences of intravenous psychoactive drug use among female teenagers (HC). According to this study, more Motivational Enhancement Therapy (MET), family counselling, and cognitive-behavioural therapy should be used to free female adolescents from the shackles of intravenous psychoactive substance use.