Monkeypox is a zoonotic viral disease that was identified in 1958 in research monkeys that came from Singapore. It is an orthopoxvirus that belongs to the Poxviridae family [1]. This viral infection was restricted to Africa but in the last year the cases started raising not only in Africa but in the rest of the world [1,2]. This is why it became a disease of interest; it is important to acknowledge its epidemiological behavior, risks and vaccines, especially in a world that was recently struck by COVID-19, challenging physicians in the way of treating and vaccinating their immunosuppressed patients.