A small subset of pediatric patients develop a newly emerging syndrome associated with post COVID-19 infection. Termed Multisystem Inflammatory Syndrome in Children (MIS-C), this syndrome shares characteristics with Kawasaki Disease (KD), including fever, elevated inflammatory markers and multisystem involvement (cardiac, neurological, ocular, dermatological, mucocutaneous and gastrointestinal). MIS-C can have mixed presentation, creating a diagnostic challenge. We present this case of Neonatal Multisystem Inflammatory Syndrome (MIS-N) to highlight the complication of this syndrome in neonates with an aim to spread awareness of the clinical manifestations of this syndrome among the treating clinician.