Heavy metals are elements that mainly have a 5-22 gr.cm-3 specific gravity. Some of these metals are essential micronutrients for plant growth (Such as Zinc (Zn), Copper (Cu), Manganese (Mn), Nickel (Ni) and Cobalt (Co)). Some other heavy metals, have a high toxicity properties such as Lead (Pb), Cadmium (Cd) and Mercury (Hg). In order to investigate the potential of watercress (Nasturtium officinale) in the uptake of elements from nutrient solutions with different salinities, a factorial experiment was conducted in a completely randomized design with three replications in the greenhouse. In this experiment, different levels of arsenic were zero, 5, 10, 20, 40, 40, 80 and 160 mg.L-1, which were obtained from sodium arsenate source and added to Epstein’s nutrient solution to obtain the mentioned concentrations. The salt concentration of the nutrient solution was 0, 10, 20, 40 and 80 mM which was prepared from sodium chloride source and added to Epstein solution. After making nutrient solutions with different salinity and concentrations, watercress was cultivated. The ANOVA results showed that the interaction of salinity and arsenic levels on the calcium, magnesium, iron, manganese, zinc and copper concentrations in watercress was significant at the level of one percent probability. The highest concentrations of these elements were obtained in the levels without salinity and arsenic and the lowest values were obtained in the 80 mM salinity levels and 160 mg.l-1 arsenic.