Cancer & Oncology Research
Section Editors
Giuseppe Murdaca
Joan-Lluis Vives-Corrons
Anastasios E Germenis
Andrii Puzyrenko
Andrii Puzyrenko
   Alyssa Summers
CARLO MARETTI
Dr. Jian-Hui Xiao
Dr. Stella D’Oronzo
Edoardo Maria Muttillo
Elena Levantini
Emil Bulatov
Fernando Mendes
Giordana Bettini
Jin-Seok Lee
Mosab Shetiwy
Prof. Alexander Sirotkin
Prof. Dr. Ricardo Hsieh
Sorush Niknamian
Tao Zhang
Tetiana V. Serebrovska
Vijay Mahant
Xiang Wang
Xiaobin Zeng
Research Topics in this Section
Cancer
53
CancerThese topics are filtered from our journals helping to discover the community within the widespread of multi-disciplinary Ha…
Immunotherapy
10
ImmunotherapyThese topics are filtered from our journals helping to discover the community within the widespread of multi-discipli…
Oncology
49
OncologyThese topics are filtered from our journals helping to discover the community within the widespread of multi-disciplinary …
Pathology
23
PathologyThese topics are filtered from our journals helping to discover the community within the widespread of multi-disciplinary…
Radiation Therapy
14
Radiation TherapyThese topics are filtered from our journals helping to discover the community within the widespread of multi-disc…
Recent Articles
50 articles
Open Access
Retrospective Cohort Study 09 May 2026
Magnetic Resonance Imaging with Apparent Diffusion Coefficient (ADC) Mapping: A Diagnostic Tool for Differentiating Orbital Lymphomas from other Lesions
Purpose: To evaluate the utility of absolute and relative apparent diffusion coefficient (ADC and ADCr) in differentiating orbital lymphoma from other orbital lesions.Design: Retrospective observational study.Participant…
13 Views 75 Downloads
Open Access
Research Article 29 Apr 2026
Down-Regulation of Ephrin-B1 in Left Ventricular Non-Compaction
Background: Left Ventricular Non-Compaction (LVNC) is a rare cardiomyopathy with incompletely understood pathophysiological mechanisms. Ephrin-B1 (Ep), a key protein of cardiomyocyte lateral junctions, may play a role in…
7 Views 54 Downloads
Open Access
Review Article 22 Apr 2026
Therapeutic Strategies in Acute Myeloid Leukemia: Current Advances and Future Directions
Acute Myeloid Leukemia (AML) is a clinically aggressive and molecularly heterogeneous hematologic malignancy characterized by poor long-term outcomes, largely due to high rates of relapse and therapeutic resistance. For …
15 Views 56 Downloads
Open Access
Review Article 22 Apr 2026
Daivavyapashraya Chikitsa in Cancer Care: Bridging Ancient Wisdom with Modern Oncology
Background: Cancer affects patients far beyond the physical burden of disease. Emotional distress, uncertainty, existential suffering, and unmet spiritual needs frequently accompany diagnosis, treatment, survivorship, an…
17 Views 43 Downloads
Open Access
Research Article 28 Feb 2026
The Expanding Landscape of NLRC4 Inflammasome in Various Inflammatory and Infectious Diseases
Background: The Nucleotide-binding oligomerization domain-Like Receptor family CARD domain-containing 4 (NLRC4) inflammasome is a critical component of innate immunity. As an intracellular pattern recognition receptor, N…
11 Views 75 Downloads
Open Access
Case Report 28 Feb 2026
Giant Chondrolipoma of the Breast: A Rare Report of Breast within a Breast
9 Views 71 Downloads
Open Access
Case Report 25 Feb 2026
Genital Schistosomiasis - Induced Infertility: A Case Report
Bilharzias is Schistosomiasis is prevalent in tropical and subtropical countries such as Yemen. Urogenital schistosomiasis can cause infertility in both males and females. Severe schistosomiasis can cause intense granulo…
6 Views 63 Downloads
Open Access
Review Article 19 Feb 2026
Bleeding and Thrombotic Complications in Patients with Premalignant Hematologic Conditions: Diagnostic and Therapeutic Challenges
Premalignant hematology patients categorized as monoclonal B-cell lymphocytosis, clonal cytopenia of indeterminate importance, monoclonal gammopathy of unknown relevance, and clonal hematopoiesis. These disorders are cat…
10 Views 63 Downloads
Open Access
Research Article 19 Jan 2026
Novel Oncoplastic Surgery for Long-Term Outcome and Prediction of Breast Cancer Survival beyond Serial Axillary Dissection – A Prospective Study
Study background: Axillary Lymph Node Dissection (ALND) maintains therapeutic value in high-risk Breast Cancer (BC), while sentinel lymph node biopsy is the standard for staging early-stage, clinically node-negative case…
40 Views 75 Downloads
Open Access
Review Article 30 Dec 2025
Boron Neutron Capture Therapy in Cutaneous Melanoma: Novel Delivery Strategies
Cutaneous Melanoma (CM), with its profound heterogeneity and capacity for therapy resistance, represents a persistent challenge in oncology. This review charts the evolution of management strategies from a refined unders…
85 Views 76 Downloads
Open Access
Review Article 16 Dec 2025
FAM40A Deficiency Activates the Hippo Pathway to Promote Podocyte Apoptosis and Contribute to FSGS
Background: Focal Segmental Glomerulosclerosis (FSGS), a major cause of end-stage renal disease, is characterized by podocyte loss via apoptosis and cytoskeletal disruption. Although dysregulation of the Hippo-YAP pathwa…
85 Views 69 Downloads
Open Access
Review Article 08 Nov 2025
Exploring the Tumor Microenvironment: Macrophages and PD-1 Checkpoint Inhibitors
This review provides an in-depth examination of the tumor microenvironment, macrophages, and PD-1 checkpoint inhibitors. It delves into the fundamental aspects of the tumor microenvironment and macrophages, discussing th…
446 Views 75 Downloads
Open Access
Review Article 05 Nov 2025
The Cellular Crosstalk between the Endothelial Cells and Immune Cells in the Metastasis of NSCLC
Background: Bone and brain metastasis are common in the NSCLC, and tumor environment has played a vital role in the metastasis, endothelial cells are a key component of the tumor microenvironment and its role in the deve…
189 Views 73 Downloads
Open Access
Perspective 23 Oct 2025
Quercetin Analogs as Cancer Chemopreventive Agents: A New Perspective
Quercetin is a flavonoid-type chemical molecule found in many people's daily diets. Previous research has shown that quercetin offers a range of benefits, including anti-inflammatory, antioxidant, and cancer-prevention p…
760 Views 80 Downloads
Open Access
Comparative Studies 21 Oct 2025
The Correlation between the Efficacy and Survival of Chemotherapy Combined with PD-1 and Granulocyte Colony-Stimulating Factor in Patients with Advanced NSCLC
Objective: This study investigates the relationship between the prophylactic use of granulocyte colony-stimulating factors and clinical efficacy, as well as survival outcomes, in patients with advanced non-small cell lun…
205 Views 82 Downloads
Open Access
Review Article 18 Oct 2025
A Comprehensive Review of Computational Modeling in Tumor and Brain Disorder with a Focus on Ablation Therapies
This review paper provides a comprehensive overview of computational modeling approaches applied to the study of tumors and brain disorders, with a particular focus on ablation therapies. We delve into the fundamental pr…
257 Views 73 Downloads
Open Access
Case Report 15 Oct 2025
Cis-platin Plus Paclitaxel Treatment in Cervical Carcinoma induce Hyperthyroidism: A Case Report
A patient in their 70s with cervical carcinoma developed hyperthyroidism after receiving treatment with cisplatin and paclitaxel. Laboratory tests confirmed the patient’s hyperthyroid status. Following the administrati…
321 Views 85 Downloads
Open Access
Review Article 19 Sep 2025
Clinical Features of AL Amyloidosis Presenting with Raccoon Eyes: A Case Report and Literature Review
Objective: This study presents and examines the clinical profiles of 28 patients with immunoglobulin light chain (AL) Amyloidosis who exhibit the characteristic “raccoon eye†appearance. It seeks to delineate the typ…
297 Views 74 Downloads
Open Access
Case Report 20 Jun 2025
Anastomotic Renal Sinus Haemangioma - A Case Report
Rationale: Vascular tumours of the kidney are a heterogeneous group of lesions showing common characteristics with malignant neoplasms, making it significantly challenging the pre-operative diagnosis. Among these lesions…
205 Views 80 Downloads
Open Access
Review Article 16 Jun 2025
Modulation of Inflammation in Cardiac Function after Myocardial Infarction
511 Views 77 Downloads
Open Access
Review Article 17 May 2025
The Role of Translation Initiation Regulation in Tumorigenesis, Progression and Drug Resistance
The initiation of mRNA translation plays a pivotal role in gene expression and has profound implications for tumorigenesis, tumor progression, and drug resistance. eIF4F complex, as an important part of the classical tra…
2,092 Views 87 Downloads
Open Access
Editorial 30 Apr 2025
Cancer & Oncology Research: Driving Innovations for Better Outcomes
401 Views 87 Downloads
Open Access
Research Article 28 Apr 2025
Inflammation Markers and HCC Aggressiveness
Background: Inflammation is thought to be important in the development and progression of Hepatocellular Carcinoma (HCC), but which inflammatory indices are more useful in clinical practice is not clear.Aims: Several inf…
436 Views 103 Downloads
Open Access
Mini Review 31 Mar 2025
Perspectives on an Integrated Approach to Cancer Management
While conventional treatments remain central to cancer care, emerging evidence suggests that complementary strategies may modulate tumor progression. This paper outlines an integrated approach that includes detoxificatio…
275 Views 109 Downloads
Open Access
Research Article 15 Feb 2025
Analysis of the Predictive Value of CA125 Elimination Rate Constant (KELIM) for Outcomes of Interval Debulking Surgery and Prognosis in High-Grade Serous Ovarian Cancer
Objective: To determine the cutoff value of the KELIM score in patients with High-Grade Serous Ovarian Cancer (HGSOC) undergoing Neoadjuvant Chemotherapy (NACT) followed by Interval Debulking Surgery (IDS), and to better…
525 Views 123 Downloads
Open Access
Research Article 24 Jan 2025
Comparative Study of Biomarkers Dependent on Biological, Molecular Factors and Their Clinical Significance in Breast Cancer Treatment
Breast cancer clinically represents a heterogeneous disease. Over decades, the integration of prognostic and predictive markers in treatment decisions has led to a more individualized and optimized therapy. Prognosis des…
440 Views 128 Downloads
Open Access
Opinion 26 Dec 2024
Omitting Axillary Dissection in Breast Cancer with Sentinel Node Metastases. Extending Axillary Surgical De Escalation
1,156 Views 116 Downloads
Open Access
Research Article 30 Nov 2024
Spectral Dependence of Inhibitory Effect of Blue Light on Cancer Cells and Efficacy of Light-Induced Intracellular Generation of Reactive Oxygen Species In vitro
A quarter of a century after establishment of inhibitory effect of blue light on growth of cancer cells, many aspects of mechanism of photophysical and photochemical processes underlying the effect of above physical fact…
180 Views 131 Downloads 3 Citations
Open Access
Brief Report 18 Nov 2024
Osteosarcoma in South Asia: A Brief Overview
Osteosarcoma, a primary malignant bone tumor, predominantly affects children and young adults, with a high incidence during puberty. Early diagnosis is critical due to the rapid tumor growth. Neoadjuvant chemotherapy has…
1,180 Views 114 Downloads
Open Access
Research Article 25 Oct 2024
CA19-9 as a Diagnostic Biomarker for Pancreatic Cancer
CA19-9 is a biomarker often used in pancreatic cancer diagnosis; it measures serum CA19-9 levels in the blood which corresponds to cancer status and even staging. It is used clinically but not as a screening biomarker as…
3,980 Views 116 Downloads 1 Citation
Open Access
Short Communication 22 Oct 2024
Cell-to-Cell Communication in Prostate Differentiation and Cancer
259 Views 114 Downloads 2 Citations
Open Access
Observational Studies 07 Oct 2024
Shroud of Turin What Happened to Jesus Christs Human Body after Death?
Based on the compatibility between what can be scientifically detected on the TS (Turin Shroud) - having recognized Jesus Christ in the double body image visible there - and what is reported in the CHB (Christian Holy Bi…
2,181 Views 230 Downloads
Open Access
Retrospective Cohort Study 30 Sep 2024
Unplanned Excision of Soft Tissue Sarcoma The Impact of Residual Disease in Re Excision Specimen
Background: This study aims to assess the oncologic outcomes of unplanned versus planned excision in patients with high-grade soft tissue sarcoma. Methods: A retrospective review was conducted, including 147 patients sur…
444 Views 120 Downloads 3 Citations
Open Access
Research Article 27 Sep 2024
Populations of Triple Negative and Hormone Receptor Positive HER2 Negative Breast Tumors Share Immune Gene Profiles
Background: Immune therapy has revolutionized the treatment of certain cancers including melanoma and lung cancer. Breast cancer has fewer tumors with high immune infiltrate and Immune Checkpoint Inhibitor (ICI) therapy…
218 Views 116 Downloads
Open Access
Mini Review 31 Aug 2024
Imatinib-Dependent Ascites as a Side Effect of Abdominal Surgery
Atypical fluid retention is an uncommon side effect of imatinib therapy. This case report describes ascites that developed post-Abdominal Aortic Aneurysm (AAA) repair in a man on imatinib for Chronic Myeloid Leukemia (C…
502 Views 97 Downloads
Open Access
Case Report 31 Aug 2024
Unusual Cause of the Chest Pain: Oesophageal Lipoma
278 Views 104 Downloads
Open Access
Research Article 21 Aug 2024
Age-Specific Survival in Lung Cancer in the Nordic Countries through a Half Century
Background: Lung cancer (LC) is often diagnosed at a late stage in relatively old persons whose survival may be compromised because of limited treatment. Our aim was to carry out an age-specific survival study on LC in D…
386 Views 111 Downloads 2 Citations
Open Access
Research Article 16 Aug 2024
Patterns of Recurrence in Patients with Non Metastatic Head and Neck Squamous Cell Cancer. Can Radiotherapy Interruptions Influence The Patients Prognosis?
Aims: To determine the impact of interruptions/suspensions of radiotherapy in relation to the stage and histopathological features in patients with Non-Metastatic Head and Neck Squamous Cell Cancer (NMHNSCC), undergoing …
350 Views 117 Downloads 1 Citation
Open Access
Case Report 12 Aug 2024
Crystal Induced Colitis Mimicking Crohns Disease
Crystal-induced colitis, a rare complication of sevelamer therapy in Chronic Kidney Disease (CKD) patients, presents diagnostic challenges. We report a case of a 39-year-old man with severe lower gastrointestinal bleedin…
297 Views 117 Downloads
Open Access
Research Article 11 Jul 2024
Surgical Approach to Retroperitoneal Sarcomas with Involvement of the Permeable Inferior Vena Cava: Use of the Femorojugular Bypass
Introduction: Retroperitoneal sarcomas with Inferior Vena Cava (IVC) involvement are rare cases and complex to manage. Radical surgical resection is the only potentially curative treatment and sometimes clamping of the I…
351 Views 110 Downloads
Open Access
Clinical Trials 08 Jul 2024
Effect of Hyperthermic Intraperitoneal Chemotherapy on Long Term Survival in Gastric Cancer with Peritoneal Metastasis Treated With Preoperative Intraperttoneal Chemotherapy plus Peritonectomy: The Phase III PM-GC-1 Trial
The presentation aims to describe the theory for Comprehensive Treatment (COMPT) in order to achieve cure of Colorectal Cancer (CRC)-patients with Peritoneal Metastasis (PM). Comprehensive Treatment (COMPT) consists of c…
1,585 Views 106 Downloads
Open Access
Case Report 21 Jun 2024
Aeromonas hydrophila Septicaemia in a 6-Month-Old Infant: A Case Report
Background: Aeromonas hydrophila, a Gram-negative, motile, facultative anaerobe, is emerging as a serious pathogen. It is found in water, soil, and food, causing various infections, from mild diarrhoea to life-threatenin…
378 Views 96 Downloads 1 Citation
Open Access
Commentary 14 Jun 2024
Predictive Pathologic Features of Nodal Metastasis and Tumor Recurrence in HPV-Associated Endocervical Adenocarcinoma
Endocervical Adenocarcinoma (EAC) is the second most prevalent malignancy of the uterine cervix, with a significant portion linked to high-risk HPV infection [1]. The incidence of EAC has risen notably, now accounting fo…
353 Views 98 Downloads
Open Access
Editorial 08 Jun 2024
The Promise of Tumor Mutation Burden and Microenvironment as Biomarkers in Glioma Treatment
Gliomas, particularly high-grade gliomas like glioblastomas, represent some of the most formidable challenges in oncology. These brain tumors are notorious for their resistance to conventional therapies, including surger…
410 Views 103 Downloads
Open Access
Research Article 25 Apr 2024
Comparative Study of Breast Cancer in Women Under 40 Compared to Older Women: The Experience of the Mohammed VI Center
Context: Breast cancer in young women is relatively rare worldwide, with patients under the age of 35 accounting for only 2% to 25% of all women diagnosed with this cancer. The objective of this study is to describe the …
1,714 Views 86 Downloads
Open Access
Review Article 20 Apr 2024
Differentiating Compromised Mitochondria of Lung Cancer Cells from Mitochondria in Healthy Cells
Mitochondria are double-walled organelles that generate energy in the form of ATP. ATP is an energy-rich compound and a driver of fundamental cell functions. Mitochondria-oriented studies help design advanced therapies t…
5,203 Views 101 Downloads
Open Access
Short Communication 01 Feb 2024
Artificial Provoking the Apoptosis of Tumoral Cells as Potential Approach in Healing of Malignant Tumors
As already known, traditional approaches in healing of many kinds of malignant tumors unfortunatelly still gives bad results. Also, our immune system is not able to respond on malignant tumors in an adequate capacity, be…
574 Views 115 Downloads
Open Access
Original Article 26 Jan 2024
Comparative Evaluation of Microorganism Disinfection Methods for N95 Respirators
Background: An excessive demand for N95 respirators occurred during the SARS-CoV-2 pandemic. Therefore, health care workers were obligated to reuse N95 respirators, which were intended to be disposable.Aim: The primary o…
1,072 Views 142 Downloads
Open Access
Brief Communication 15 Jan 2024
Auctox A New Method to Evaluate the Safety of Anticancer Drugs
The evaluation of anticancer drugs safety is currently based on considering the worst Adverse Event (AE) in a particular patient. The aim of the study was to define a new method which would better describe the impact of …
644 Views 116 Downloads
Open Access
Retrospective Cohort Study 31 Dec 2023
Constipation in Hepatocellular Carcinoma Patients: Navigating Clinical Challenges, Hospital Stays and Opioid-Related Risks for Enhanced Patient Care and Outcomes
Background: Constipation can be a significant clinical challenge, impacting patient care and extending hospital stays. We examined the effects of constipation on Hepatocellular carcinoma patients, especially due to incre…
737 Views 97 Downloads