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Home/ All Articles/ Analysis of the Predictive Value of CA125 Elimination Rate Constant (KELIM) for Outcomes o…

Abstract & Article Details

Research Article • Vol.6, Issue 2 • ISSN: 2766-2276 • Open Access • CC BY 4.0

Open Access Research Article Vol.6, Issue 2 February 15, 2025

Analysis of the Predictive Value of CA125 Elimination Rate Constant (KELIM) for Outcomes of Interval Debulking Surgery and Prognosis in High-Grade Serous Ovarian Cancer

DOI: 10.37871/jbres2066
Authors
Chaorong Zeng and Zhuoying Hu*
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Abstract

Objective: To determine the cutoff value of the KELIM score in patients with High-Grade Serous Ovarian Cancer (HGSOC) undergoing Neoadjuvant Chemotherapy (NACT) followed by Interval Debulking Surgery (IDS), and to better assess the significance of the KELIM score as a prognostic and predictive indicator for HGSOC.

Methods: A total of 124 patients with HGSOC who underwent NACT+IDS were included. The Receiver Operating Characteristic (ROC) curve and Youden index were used to determine the cutoff value of the KELIM score for predicting complete cytoreductive surgery (R0 resection) in HGSOC patients undergoing NACT. Logistic regression analysis was conducted to identify factors predicting complete cytoreductive surgery, and Cox regression analysis was used to assess the correlation between the KELIM score and recurrence and mortality in HGSOC. Based on the cutoff value of the KELIM score, patients were divided into two groups, and differences in clinic pathological parameters between the groups were compared.

Results: The optimal cutoff value of the KELIM score for predicting R0 resection was 1.25. The KELIM score was identified as an independent risk factor for both R0 resection and recurrence in patients with HGSOC.

Conclusion: A KELIM score cutoff of 1.25 is optimal for predicting complete cytoreductive surgery and recurrence in patients with high-grade serous ovarian cancer.

FullText HTML FullText PDF DOI: 10.37871/jbres2066 CrossMark

Research Topics

Oncology Gynecology Cancer

How to Cite

Chaorong Zeng and Zhuoying Hu* (2025). Analysis of the Predictive Value of CA125 Elimination Rate Constant (KELIM) for Outcomes of Interval Debulking Surgery and Prognosis in High-Grade Serous Ovarian Cancer. Journal of Biomedical Research & Environmental Sciences, 6(2). https://doi.org/10.37871/jbres2066

Article Information

JournalJournal of Biomedical Research & Environmental Sciences (JBRES)
ISSN2766-2276
DOI DOI 10.37871/jbres2066
Volume / IssueVol. 6, Issue 2
PublishedFebruary 15, 2025
Article TypeResearch Article
Pages139-152
LicenseCC BY 4.0 — Open Access
PublisherSciRes Literature LLC, Sheridan, WY, USA
LanguageEnglish
Creative Commons BY 4.0

Published under CC BY 4.0 — free to share, copy, adapt, and redistribute with attribution.

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Certificate of Publication — Analysis of the Predictive Value of CA125 Elimination Rate Constant (KELIM) for Outcomes of Interval Debulking Surgery and Prognosis in High-Grade Serous Ovarian Cancer
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