Depression is one of the most common and widespread medical issues and major depression is also one of the most disabling of all medical conditions. Although enormous efforts have been invested in research, there is no evidence that an abnormality in serotonin levels or other monoamines causes depression or that certain people are genetically predisposed to produce too little serotonin and therefore to experience depression. As Allen Frances, the Chair of the Diagnostic and Statistical Manual IV (DSM-IV) Task Force said: “Billions of research dollars have failed to produce convincing evidence that any mental disorder is a discrete disease entity with a unitary cause. Dozens of different candidate genes have been “found,” but in follow-up studies, each turned out to be fool’s gold.” Now we just have to figure out WHAT we can trust. Proper education for the students and teachers is one approach.