Membranous Glomerulonephritis (GMN) is an autoimmune disease whose etiology has not been defined with precisión, When there is no association with another disease which ocurrs in two thirds of the cases is considered to be idiopathic. It is the most common cause of Nephrotic Syndrome in Adults, primary caucasic and over 60 years of age. It is regarded as a non inflammatory Glomerulonephritis, concept with which I am not completely in agreement because I think as other researchers have taught than in GMN [1] the Complement system contributes to various Glomerulophaties by causing cellular damage by both an inflammation-dependant and inflammation-independent ways. Here I discuss a case of a woman who developed an idiopathic GMN presented with a nephrotic síndrome with severe protracted proteinuria also I describe her initial treatment and the changes that I made and discuss her follow up for 7 years, and current medical status.