A hypoxanthine modified polyethylene glycol diglycidyl ether gel was prepared by the ring opening polymerization of polyethylene glycol diglycidyl ether with hypoxanthine in a simple sol-gel method. The structure and composition were characterized by SEM, FT-IR, BET and XRD. The adsorption experiments of ciprofloxacin at different pH, temperature, contact time and initial concentration were studied. The results show that the gel is porous with the average pore size of 5.2 nm, the optimum adsorption pH is 5 and the saturated adsorption time is 240 minutes. The maximum equilibrium adsorption capacity of ciprofloxacin is 56.1 mg/g at 308 K according to the Langmuir model. The repeated adsorption experiments show that the gel could still adsorb 80% of the first adsorbed ciprofloxacin after 5 times of elution. These results indicate that the gel can be used as a practical adsorbent for ciprofloxacin in aqueous solution.