Emerging evidence from both human and animal studies indicates that circadian rhythm disruption during critical developmental periods can have profound long-term consequences for cardiovascular health. This review synthesizes current knowledge on the impact of maternal circadian disturbance during pregnancy on cardiac remodeling in offspring, with particular emphasis on sex-specific effects and underlying molecular mechanisms. Drawing from recent experimental models, we explore how in utero circadian disruption predisposes offspring, especially males, to pathological cardiac remodeling, characterized by ventricular chamber dilatation, enhanced myocardial fibrosis, decreased contractility, and increased susceptibility to arrhythmias. However, emerging evidence also indicates that female offspring are not entirely spared, with risks potentially mediated through other pathways such as pregnancy complications. The review highlights the emerging role of sex-specific molecular pathways, including the secret globin gene, Scgb1a1, alongside other key mechanisms such as epigenetic regulators and inflammatory pathways, and discusses how circadian gene expression alterations in the heart contribute to these phenotypes. Understanding these relationships provides crucial insights into the developmental origins of cardiovascular disease and may inform future prevention strategies targeting circadian health during pregnancy.