Nerium oleander Lin, which is the only species listed in the genus Nerium and a member of the Apocynaceae family, was frequently employed in traditional medicine to address various pathologies. N. oleander has demonstrated its efficacy in various disease models at a time when pharmaceutical firms are focusing more on plant-based traditional medicines to prevent side-effects and resistance against synthetic drugs. Neriin, oleandrin, cardenolides, gentiobiosyl, and odoroside are just a few of the cardiac glycosides that are present in this plant and are toxic in all sections. Additionally, this plant species creates secondary metabolites with pharmacological value, such as alkaloids, flavonoids, and steroids.