Infertility is a common problem that affects many couples worldwide, with an estimated 48.5 million couples experiencing infertility. The causes of infertility are diverse and complex, with a combination of genetic, environmental, and lifestyle factors contributing to the problem. While reproductive medicine has advanced significantly in recent years, the diagnosis and treatment of infertility remains a challenge, particularly in cases where the cause is not clear. One factor that has been found to contribute to infertility is abnormalities in coagulation.

Coagulation is an essential process that helps to prevent bleeding and promote healing after injury. However, when coagulation is abnormal, it can lead to various health problems including infertility. Studies have shown that coagulation disorders may affect reproductive function by interfering with blood flow, ovulation and implantation may lead to inflammation and oxidative stress.

Moreover, the balance between coagulation and fibrinolysis is crucial in coagulum formation and liquefaction of seminal plasma in males.

Despite the growing body of research on the relationship between coagulation and infertility, there is still much to be learned. In this review, we will examine the current understanding of the relationship between coagulation abnormalities and infertility. We will discuss the potential mechanisms by which coagulation disorders may affect reproductive function and explore the evidence linking coagulation disorders to infertility, recurrent pregnancy loss, and implantation failure. Finally, we will consider the implications of these findings for clinical practice and future research.