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Background: KRAS oncogene is involved in colorectal carcinogenesis in 22 to 45% of cases. KRAS mutations can render Epidermal Growth Factor Receptor (EGFR) inhibitors ineffective. The present study is aimed to determine the molecular diversity, frequency, and characteristics of KRAS mutations in metastatic Colorectal C…

Biodiesel production has been studied using non-edible seed oil from Thevetia peruviana. The non-edible oil from Thevetia peruviana seed could be used as a feedstock for biodiesel manufacturing. In this paper, the production of biodiesel utilizing Thevetia peruviana Seed Oil (TPSO) has been investigated. The ripe seeds…

The process of bacterial transformation results from the introduction of specific genetic material into bacteria cells and subsequent gene expression. This technology has significant applications in gene cloning technology, and allows new possibilities for genetic breeding. The use of cellulose and babassu mesocarp to …

Endothelin-1 (ET-1) is a potent bioactive mediator that induces vasoconstriction and promotes vascular remodeling. Previous studies indicate that ET-1 plays an important role in the pathophysiology of humans. This includes various cardiovascular and renal complications.Some humans with chronic heart failure might also …

The aim of the presented research is to assess the degree of burdening the EU economies with the effects of cancer in the context of the limitations diagnosed of the labor market potential in the Member States. Particular attention was paid to the problem of existing inequalities in the level of burdening national econ…

Each year, thousands of patients suffer from sacral decubitus ulcers, also known as pressure ulcers or sores. The current standard of care for sacral decubitus ulcer treatment is expensive and suboptimal, ranging in cost from a 15-dollar tube of Neosporin Ointment to 240,000 dollars for a skin flap surgery. Grade II pr…

Suspicion for Cardiac Amyloidosis (CA) led a 75-year-old male patient with fatigue, dyspnea, and palpitations to be subjected to scintigraphic myocardial investigation with technetium-99m-pyrophosphate (99mTc-PYP, or PYP scan) in order to distinguish transthyretin-related CA (ATTR) from the light-chain Amyloidosis (AL)…

Cancer and Cardiovascular Disease (CVD) are the most common causes of death and disability in many countries. Cancer and CVD are closely related in terms of both scientific and clinical perspectives. Oncocardiology has recently gained attention by oncologists, cardiologists, and radiologists for mutual work on pathophy…

Combine modality anti-cancer treatment, Concurrent Chemo-Radio Therapy (CCRT) is a recommended approach for relatively resistant tumor in clinical oncology. But it is relatively more toxic to patient, and severely disrupt patient’s quality of life due to systemic side-effects causing by intravenous cytotoxic drugs de…

Numerous experimental studies demonstrate key aspects of mechanical ventilation which initiate or exacerbate acute lung injury, characterized by proteinaceous edema, inflammation, and hemorrhage. The great majority of these investigations into Ventilator-Induced Lung Injury (VILI) have focused on the characteristics of…

It is an attractive idea to make a single drop of blood sufficient for the diagnosis of many diseases. This was exactly what the biotech company Theranos Inc., founded in 2003 by a 19-year-old girl, Elizabeth Holmes, claimed. Unfortunately, their health technology turned out to be a fraud, and Elizabeth was charged by …

Background: Factor V plays a crucial role in the coagulation process. Factor V Leiden (FVL) is considered a mutant form of factor V, which may contribute to blood vessel thrombosis. Also, Hepatitis C Virus (HCV) infection may exert some coagulation changes leading to Portal Vein Thrombosis (PVT). Thrombocytopenia in pa…

In modern medicine and biotechnology, metal frames and mineral carriers modified with polymer coatings are widely used. In most cases, during polymerization, hydrolytically stable bonds between the polymer and the carrier are not formed on the surface, and the modifying layer is retained on the surface due to adsorptio…

Background: Post-stroke hemiplegic gait is a mixture of deviations and compensatory motion dictated by residual function. To improve stroke survivors' walking ability, it is necessary to evaluate different rehabilitation approaches and identify those that have a greater effect on locomotor recovery of stroke patient. T…

In 2014, the French National Agency for Food, Environmental and Occupational Health Safety (Agence nationale de sécurité sanitaire de l'alimentation de l'environnement et du travail) in its annual report wrote: "Nanomaterials can be absorbed by the body and migrate to other organs, leading to a potential systemic ris…