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Objectives: Lamivudin has been approved for the treatment of chronic hepatitis B but experience with lamivudin treatment for acute severe hepatitis B is still limited. Fulminant hepatitis develops in 1% of patients with acute hepatitis B. Severe acute hepatitis B in immunocompetent patients may progress to fulminant he…

Streptomyces is a biocontrol agent capable of protecting walnut from stem rot disease caused by the fungal pathogen Cytospora chrysosperma. Antagonistic strains were selected from walnut rhizosphere soil for biocontrol of the disease. The strains were screened using C. chrysosperma as the target pathogen. Using dilutio…

Knee osteoarthritis, also known as osteoarthritis of the knee, is a degenerative condition of the knee joints. It occurs when the cartilage covering the joint surfaces of the knee progressively wears away, resulting in pain, swelling, stiffness and loss of function in the affected knee. Cartilage is a smooth, tough tis…

Background: Aeromonas hydrophila, a Gram-negative, motile, facultative anaerobe, is emerging as a serious pathogen. It is found in water, soil, and food, causing various infections, from mild diarrhoea to life-threatening sepsis. Young children, older people, and immunocompromised people are most susceptible. While t…

Background: In oncology, Patterns of Care (PoC) provide a detailed overview of all cancer-treatment interventions and recapitulate the entire patient’s journey. While manual-chart PoC reviewing is time-consuming, the use of Electronic Health Records (EHRs) enables the creation of data-mining solutions to automaticall…

The objectives of this study is to summarize and analyze the clinical and pathological data of patients with feeding jejunostomy, evaluate its clinical application value and risk, and study the optimal selection of enteral nutrients. The clinical data of 238 patients who underwent feeding jejunostomy in Beijing Shijita…

Spectroscopic methods relying on light sources play a crucial role in the identification of protein-ligand interactions. Such experimental techniques open doors for scientists to employ them in disease prevention, treatment, drug synthesis, identification of pathways contributing to different disorders, and unveiling t…

Woltman’s Sign, the delay in the relaxation phase of the Achilles reflex, has long been recognised as the hallmark of overt hypothyroidism. It is most easily observed with the ankle jerk [1] but delayed relaxation can readily be demonstrated in all deep tendon reflexes including the biceps [2,3]. With hypothyroid pat…

Endocervical Adenocarcinoma (EAC) is the second most prevalent malignancy of the uterine cervix, with a significant portion linked to high-risk HPV infection [1]. The incidence of EAC has risen notably, now accounting for up to 25% of new cervical cancer diagnoses at 1.44/100,000 women in the United States [2]. Overall…

Modeling and simulation approaches such as Physiologically Based Pharmacokinetic (PBPK) and Physiologically Based Biopharmaceutics Modeling (PBBM) are gaining importance due to their impact to transform drug development paradigm. Development of such modeling approaches include integration of drug substance, drug produc…

A return to the climate of the middle Pliocene is probable within this century and the increased temperatures, particularly at higher latitudes, will boost the spread of several bacterial, viral and protozoan parasite pathogens which cause severe and/or lethal diseases. The warmer climate effects on the spread and evol…

Purpose: Cultivation of Pleurotus spp. (Oyster mushroom) is economically feasible, exploiting its great capacity to degrade cellulose, lignin and hemicelluloses present in organic wastes. Waste paper is a very common pollutant thrown as garbage with no recycling plan in the environment. In view of the growing importanc…

Practicing physical activity correctly and regularly by adolescents can have positive effects on body image. In addition, it promotes the development of a positive relationship with your own body and improves your emotional well-being. In this sense, the objectives of this study were to carry out a systematic review of…

We used a comprehensive and culturally normed battery of Neurocognitive (NC) tests to evaluate NC impairment (NCI) in 406 adults with prior IV heroin use who were in a government-supervised methadone maintenance program in Yunnan province, China. Participants included 202 without HIV infection, 57 with AIDS, and 147 HI…